Altered ethylbenzene-mediated hepatic CYP2E1 expression in growth hormone-deficient dwarf rats

Toxicology and Applied Pharmacology

Volumn 179, Issue 2, 2002, Pages 74-82

  Zhang, Shuxin ^a   Cawley, George F ^a   Eyer, Charles S ^a   Backes, Wayne L ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; CYTOCHROME P450 2E1; ETHYLBENZENE; FOLLITROPIN; GROWTH HORMONE; HYPOPHYSIS HORMONE; LUTEINIZING HORMONE; PROLACTIN; THYROTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DWARFISM; ENZYME INDUCTION; GROWTH HORMONE DEFICIENCY; HYPOPHYSECTOMY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE;

ANIMALIA;

EID: 0036496033     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9349     Document Type: Article

References (55)

1. Differential expression of gender-dependent hepatic isoforms of cytochrome P-450 by pulse signals in the circulating masculine episodic growth hormone profile of the rat
2. Production of discrete changes in dopamine and noradrenaline levels and turnover in various parts of the rat brain following exposure to xylene, ortho-, meta-, and para-xylene, and ethylbenzene
3. Relationship between hydrocarbon structure and induction of P450: Effects on protein levels and enzyme activities
4. Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat
5. Pubertal development and testicular function in the male growth hormone-deficient rat
6. Pituitary component of the aromatic hydrocarbon-mediated expression of CYP2B and CYP2C11
7. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin increases the potency of androgens and estrogens as feedback inhibitors of luteinizing hormone secretion in male rats
8. Evidence from dwarf rats that growth hormone may not regulate the sexual differentiation of liver cytochrome P450 enzymes and steroid 5 alpha-reductase
9. Growth hormone (GH) secretion in the dwarf rat: Release, clearance and responsiveness to GH-releasing factor and somatostatin
10. Growth hormone-deficient dwarfism in the rat: A new mutation
11. A study of the skin absorption of ethylbenzene in man
12. Exposure to various benzene derivatives differently induces cytochromes P450 2B1 and P450 2E1 in rat liver
13. Roles of pituitary hormones in the regulation of hepatic cytochrome P450IIE1 in rats and mice
14. Regulation of hepatic cytochrome P450 2C11 by glucocorticoids
15. Induction of cytochrome P450 isozymes in rat liver by methyl n- alkyl ketones and n-alkylbenzenes: Effects of hydrophobicity of inducers on inducibility of cytochrome P450
16. Circadian alterations in prolactin, corticosterone, and thyroid hormone levels and down-regulation of prolactin receptor activity by 2, 3, 7, 8tetrachlorodibenzo-p-dioxin
17. Hormonal regulation of cytochrome P450 in rat liver
18. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
19. Plasma insulin, growth hormone, cortisol, and central obesity among young Chinese type 2 diabetic patients
20. Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats
21. Cytochrome P-4502E1: Its physiological and pathological role
22. Aromatic hydrocarbons in the atmosphere of the Los Angeles basin
23. Evaluation of an antisense RNA transgene for inhibiting growth hormone gene expression in transgenic rats
24. Monoclonal antibody-directed characterization of cytochrome P450 isozymes responsible for toluene metabolism in rat liver
25. Studies on prolactin and growth hormone gene expression in the pituitary gland of spontaneous dwarf rats
26. Volatile organic compounds in water at thirty Canadian potable water treatment facilities
27. Infusion of gender-dependent plasma growth hormone profiles into intact rats: Effects of subcutaneous, intraperitoneal, and intravenous routes of rat and human growth hormone on endogenous circulating growth hormone profiles and expression of sexually dimorphic hepatic cyp isoforms
28. Effect of ethanol on endogenous rhythms of growth hormone secretion
29. Effect of ethanol on spontaneous and stimulated growth hormone secretion
30. Hypothalamic site of action of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)
31. Growth hormone in obesity
32. Ethylbenzene-mediated induction of cytochrome P450 isozymes in male and female rats
33. Temporal changes in P-450 2E1 expression with continued ethylbenzene exposure
34. Effect of hypophysectomy and growth hormone replacement on the modulation of P450 expression after treatment with the aromatic hydrocarbon ethylbenzene
35. Gender differences in drug metabolism regulated by growth hormone
36. Interactions of gender, growth hormone, and phenobarbital induction on murine Cyp2b expression
37. Age- and sex-related alterations of microsomal drug and testosterone-oxidizing cytochrome P450 in Sprague-Dawley strain-derived dwarf rats
38. A specific loss of growth hormone abolished sex-dependent expression of hepatic cytochrome P450 in dwarf rats: Reversal of the profiles by growth hormone treatment
39. Growth responses in a mutant dwarf rat to human growth hormone and recombinant human insulin-like growth factor I
40. Role of glucose utilization in the restoration of hypophysectomy-induced hepatic cytochrome P450 2E1 by growth hormone in rats
41. Neuroendocrine effects in printing workers exposed to toluene
42. Hormone status in occupational toluene exposure
43. Hepatic cytochrome P450 and flavin-containing monooxygenase in male Nts:Mini rat, a transgenic rat carrying antisense RNA transgene for rat growth hormone
44. Interference with growth hormone stimulation of hepatic cytochrome P4502C11 expression in hypophysectomized male rats by 3-methylcholanthrene
45. Ethylbenzene
46. Personal exposure to volatile organic compounds. I. Direct measurements in breathing-zone air, drinking water, food, and exhaled breath
47. Monoclonal antibody-directed assessment of toluene induction of rat hepatic cytochrome P450 isozymes
48. Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450
49. Effects of growth hormone on cytochrome P-450
50. Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone
51. 2, and ferrocytochrome c and enzymic determination of extinction coefficients of cytochrome c
52. Ethylbenzene modulates the expression of different cytochrome P-450 isozymes by discrete multistep processes
53. Time course for the modulation of cytochrome P450 after administration of ethylbenzene and its correlation with toluene metabolism