DNA ploidy and autophagic protein degradation as determinants of hepatocellular growth and survival

Cell Biology and Toxicology

Volumn 13, Issue 4-5, 1997, Pages 301-315

  Seglen, P O ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Autophagy; Carcinogenesis; Hepatocyte; Liver; Ploidy; Rat

Indexed keywords

ALPHA HEXACHLOROCYCLOHEXANE; CYPROTERONE ACETATE; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; INSULIN; METHYLCLOFENAPATE; N (2 FLUORENYL)ACETAMIDE;

ANIMAL CELL; AUTOPHAGY; CELL CULTURE; CELL CYCLE; CELL GROWTH; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; DIPLOIDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CARCINOGENESIS; LIVER CELL; LIVER REGENERATION; NONHUMAN; PLOIDY; POLYPLOIDY; PRIORITY JOURNAL; RAT;

ANIMALS; AUTOPHAGY; CARCINOGENS; CELL DIVISION; CELL SURVIVAL; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LIVER REGENERATION; MITOSIS; PLOIDIES; PROTEINS;

ANIMALIA;

EID: 0030798347     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007487425047     Document Type: Conference Paper

References (58)

1. Alfert M, Geschwind H. The development of polysomaty in rat liver. Exp Cell Res. 1958;15:230-70.
2. Brodsky WY, Uryvaeva IV. Cell polyploidy: its relation to tissue growth and function. Int Rev Cytol. 1977;50:275-332.
3. Bursch W, Schulte-Hermann R. Cell death (apoptosis) in normal and preneoplastic liver tissue. In: Roberfroid MB, Préat V, eds. Experimental Hepatocarcinogenesis. New York: Plenum Press; 1988:143-59.
4. Bursch W, Grasl-Kraupp B, Ellinger A et al. Active cell death: Role in hepatocarcinogenesis and subtypes. Biochem Cell Biol. 1994;72:669-75.
5. Bursch W, Ellinger A, Kienzl H et al. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy. Carcinogenesis. 1996;17:1595-607.
6. Cameron RG. Identification of the putative first cellular step of chemical hepatocarcinogenesis. Cancer Lett. 1989;47:163-7.
7. Carriere R. The growth of liver parenchymal nuclei and its endocrine regulation. Int Rev Cytol. 1969;50:201-77.
8. Cullen JM, Linzey DW, Gebhard DH. Nuclear ploidy of normal and neoplastic hepatocytes from woodchuck hepatitis virus-infected and uninfected woodchucks. Hepatology. 1994;19:1072-8.
9. Dunn WA. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J Cell Biol. 1990;110:1923-33.
10. Evarts RP, Nagy P, Marsden E, Thorgeirsson SS. A precursor - product relationship exists between oval cells and hepatocytes in rat liver. Carcinogenesis. 1987;8:1737-40.
11. Fengsrud M, Roos N, Berg T, Liou W, Slot JW, Seglen PO. Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: Effects of vinblastine and asparagine on vacuole distributions. Exp Cell Res. 1995;221:504-19.
12. Gerlyng P, Grotmol T, Erikstein B, Stokke T, Seglen PO. Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma. Carcinogenesis. 1992a;13:1795-801.
13. Gerlyng P, Stokke T, Huitfeldt HS, et al. analytical methods for the study of liver cell proliferation. Cytometry. 1992b;13: 404-15.
14. Gerlyng P, Åbyholm A, Grotmol T, et al. Binucleation and polyploidization patterns in developmental and regenerative rat liver growth. Cell Proliferation. 1993;26:557-65.
15. Gerlyng P, Grotmol T, Seglen PO. Effect of 4-acetylaminofluorene and other tumour promoters on hepatocellular growth and binucleation. Carcinogenesis. 1994a;15:371-9.
16. Gerlyng P, Grotmol T, Stokke B, Erikstein B, Seglen PO. Flow cytometric investigation of a possible precursor-product relationship between oval cells and parenchymal cells in the rat liver. Carcinogenesis. 1994b;15:53-9.
17. Geschwind II, Alfert M, Schooley C. Liver regeneration and hepatic polyploidy in the hypophysectomized rat. Exp Cell Res. 1958;15:232-5.
18. 14C]sucrose, introduced into isolated rat hepatocytes by electropermeabilization. Exp Cell Res. 1982;142:1-14.
19. Gordon PB, Seglen PO. Prelysosomal convergence of autophagic and endocytic pathways. Biochem Biophys Res Commun. 1988;151:40-7.
20. Hendil KB. Intracellular protein degradation in growing, in density-inhibited, and in serum-restricted fibroblast cultures. J Cell Physiol. 1977;92:353-64.
21. Høyvik H, Gordon PB, Berg TO, Strømhaug PE, Seglen PO. Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine. J Cell Biol. 1991;113:1305-12.
22. Jungermann K, Kietzmann T. Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr. 1996;16:179-203.
23. Kisen GØ, Tessitore L, Costelli P et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites rat hepatoma cells. Carcinogenesis. 1993;14:2501-5.
24. Knecht E, Hernández-Yago J, Grisolia S. Regulation of lysosomal autophagy in transformed and non-transformed mouse fibroblasts under several growth conditions. Exp Cell Res. 1984;154:224-32.
25. Kopitz J, Kisen GØ, Gordon PB, Bohley P, Seglen PO. Non-selective autophagy of cytosolic enzymes in isolated rat hepatocytes. J Cell Biol. 1990;111:941-53.
26. Mossin L, Blankson H, Huitfeldt H, Seglen PO. Ploidy-dependent growth and binucleation in cultured rat hepatocytes. Exp Cell Res. 1994;214:551-60.
27. Nadal C. Polyploïdie hépatique du rat. Mode de formation des cellules binucléées. J Microscopie. 1970;9:611-18.
28. Peraino C, Staffeldt EF, Carnes BA, Ludeman VA, Blomquist JA, Vesselinovitch SD. Characterization of histochemically detectable altered hepatocyte foci and their relationship to hepatic tumorigenesis in rats treated once with diethylnitrosamine or benzo(a)pyrene within one day after birth. Cancer Res. 1984;44:3340-7.
29. Rotstein J, Sarma DSR, Farber E. Sequential alterations in growth control and cell dynamics of rat hepatocytes in early precancerous steps in hepatocarcinogenesis. Cancer Res. 1986;46:2377-85.
30. Rønning ØW, Lindmo T, Pettersen EO, Seglen PO. Effect of serum step-down on protein metabolism and proliferation kinetics of NHIK 3025 cells. J Cell Physiol. 1981a;107:47-57.
31. Rønning ØW, Lindmo T, Pettersen EO, Seglen PO. The role of protein accumulation in the cell cycle control of human NHIK 3025 cells. J Cell Physiol. 1981b;109:411-18.
32. Rønning ØW, Seglen PO. The relation between protein accumulation and cell cycle traverse of human NHIK 3025 cells in unbalanced growth. J Cell Physiol. 1982;112:19-26.
33. Sandvig K, Van Deurs B. Toxin-induced cell lysis: protection by 3-methyladenine and cycloheximide. Exp Cell Res. 1992; 200:253-62.
34. Sarafoff M, Rabes HM, Dörmer P. Correlations between ploidy and initiation probability determined by DNA cytophotometry in individual altered hepatic foci. Carcinogenesis. 1986;7:1191-6.
35. Sargent L, Xu Y-H, Sattler GL, Meisner L, Pitot HC. Ploidy and karyotype of hepatocytes isolated from enzyme-altered foci in two different protocols of multistage hepatocarcinogenesis in the rat. Carcinogenesis. 1989;10:387-91.
36. Schulte-Hermann R. Induction of liver growth and tumor promotion by drugs and environmental pollutants. In: Remmar H, Bolt HM, Bannasch P, Popper H, eds. Primary liver tumors. Lancaster: MTP Press Ltd; 1976:385-94.
37. Schulte-Hermann R. Two-stage control of cell proliferation induced in rat liver by α-hexachlorocyclohexane. Cancer Res. 1977;37:166-71.
38. Schwarze PE, Pettersen EO, Shoaib MC, Seglen PO. Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis. 1984;5:1267-75.
39. Schwarze PE, Sæter G, Armstrong D, et al. Diploid growth pattern of hepatocellular tumours induced by various carcinogenic treatments. Carcinogenesis. 1991;12:325-7.
40. Schwarze PE, Seglen PO. Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats. Exp Cell Res. 1985;157:15-28.
41. Seglen PO. Preparation of isolated rat liver cells. Meth Cell Biol. 1976;13:29-83.
42. Seglen PO, Bohley P. Autophagy and other vacuolar protein degradation mechanisms. Experientia. 1992;48:158-72.
43. Sæter G, Seglen PO. Cell biology of hepatocarcinogenesis. Crit Rev Oncogenesis. 1990;1:437-66.
44. Seglen PO, Grinde B, Solheim AE. Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin. Eur J Biochem. 1979;95:215-25.
45. 3H]raffinose as a specific probe of autophagic sequestration. Exp Cell Res. 1986;162:273-7.
46. Seglen PO. Regulation of autophagic protein degradation in isolated liver cells. In: Glaumann H, Ballard FJ, eds. Lysosomes: their role in protein breakdown. London: Academic Press; 1987:369-414.
47. Seglen PO, Skomedal H, Sæter G, Schwarze PE, Nesland JM. Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours. Carcinogenesis. 1989;10:21-5.
48. Seglen PO, Sæter G, Schwarze PE. Proliferation of diploid hepatocytes and nonparenchymal (oval) cells during rat liver regeneration in the presence of 2-acetylaminofluorene. Int J Oncol. 1994;5:805-10.
49. Seglen PO, Gordon PB. 3-Methyladenine: a specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA. 1982;79:1889-92.
50. Seglen PO, Gordon PB. Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes. J Cell Biol. 1984;99:435-44.
51. Seglen PO, Solheim AE. Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy. Exp Cell Res. 1985;157:550-5.
52. Styles JA, Kelly M, Pritchard NR, Elcombe CR. A species comparison of acute hyperplasia induced by the peroxisome proliferator methylclofenapate: Involvement of the binucleated hepatocyte. Carcinogenesis. 1988;9:1647-55.
53. Sæter G, Lee C-Z, Schwarze PE, Ous S, Chen D-S, Sung J-L, Seglen PO. Changes in ploidy distributions in human liver carcinogenesis. J Natl Cancer Inst. 1988a;80:1480-5.
54. Sæter G, Schwarze PE, Nesland JM, Juul N, Pettersen EO, Seglen PO. The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas. Carcinogenesis. 1988b;9: 939-45.
55. Sæter G, Schwarze PE, Nesland JM, Seglen PO. 2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism. Carcinogenesis. 1988c;9:581-7.
56. Sæter G, Schwarze PE, Seglen PO. Shift from polyploidizing to non-polyploidizing growth in carcinogen-treated rat liver. J Natl Cancer Inst. 1988d;80:950-8.
57. Sæter G, Schwarze PE, Nesland JM, Seglen PO. Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells. Br J Cancer. 1989;59:198-205.
58. Wheatley DN. Binucleation in mammalian liver. Studies on the control of cytokinesis in vitro. Exp Cell Res. 1972;74:455-65.