Cellular requirements for diabetes induction in DO11.10xRIPmOVA mice

Journal of Immunology

Volumn 185, Issue 8, 2010, Pages 4760-4768

  Wesley, Johnna D ^a,b   Sather, Blythe D ^a,b   Perdue, Nikole R ^a   Ziegler, Steven F ^a,b   Campbell, Daniel J ^a,b  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; EPITOPE; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RAG2 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; HLA ANTIGEN CLASS 2; INSULIN; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL INTERACTION; CELL TRANSFER; CONTROLLED STUDY; DIABETOGENESIS; DISEASE COURSE; DORMOUSE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENE; ADOPTIVE TRANSFER; ANIMAL; BAGG ALBINO MOUSE; CELL DIFFERENTIATION; CELL SEPARATION; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PROMOTER REGION; RAT; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL SEPARATION; DIABETES MELLITUS, TYPE 1; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOHISTOCHEMISTRY; INSULIN; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; OVALBUMIN; PROMOTER REGIONS, GENETIC; RATS; T-LYMPHOCYTE SUBSETS;

EID: 78049491927     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000820     Document Type: Article

References (32)

1. Achenbach, P., E. Bonifacio, K. Koczwara, and A. G. Ziegler. 2005. Natural history of type 1 diabetes. Diabetes 54 (Suppl. 2): S25-S31.
2. Ludvigsson, J., and L. G. Heding. 1978. β-Cell function in children with diabetes. Diabetes 27 (Suppl. 1):230-234.
3. Nepom, G. T. 1995. Class II antigens and disease susceptibility. Annu. Rev. Med. 46:17-25.
4. Suri, A., and E. R. Unanue. 2005. The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection. Adv. Immunol. 88:235-265.
5. Kimpimäki, T., P. Kulmala, K. Savola, A. Kupila, S. Korhonen, T. Simell, J. Ilonen, O. Simell, and M. Knip. 2002. Natural history of β-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population. J. Clin. Endocrinol. Metab. 87:4572-4579.
6. Knip, M., J. Karjalainen, and H. K. Akerblom. 1998. Islet cell antibodies are less predictive of IDDM among unaffected children in the general population than in sibs of children with diabetes. Diabetes Care 21:1670-1673.
7. LaGasse, J. M., M. S. Brantley, N. J. Leech, R. E. Rowe, S. Monks, J. P. Palmer, G. T. Nepom, D. K. McCulloch, and W. A. Hagopian. 2002. Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington State Diabetes Prediction Study. Diabetes Care 25:505-511.
8. Yanaba, K., J. D. Bouaziz, T. Matsushita, C. M. Magro, E. W. St Clair, and T. F. Tedder. 2008. B-lymphocyte contributions to human autoimmune disease. Immunol. Rev. 223:284-299.
9. Brusko, T. M., A. L. Putnam, and J. A. Bluestone. 2008. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol. Rev. 223:371-390.
10. + T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J. Exp. Med. 188:415-420.
11. + regulatory T cells in vivo. J. Exp. Med. 198:249-258.
12. Clough, L. E., C. J. Wang, E. M. Schmidt, G. Booth, T. Z. Hou, G. A. Ryan, and L. S. Walker. 2008. Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21. J. Immunol. 180:5393-5401.
13. Haskins, K., R. Kubo, J. White, M. Pigeon, J. Kappler, and P. Marrack. 1983. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 157:1149-1169. (Pubitemid 13083697)
14. Chen, J., M. Trounstine, F. W. Alt, F. Young, C. Kurahara, J. F. Loring, and D. Huszar. 1993. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int. Immunol. 5:647-656.
15. Boyman, O., M. Kovar, M. P. Rubinstein, C. D. Surh, and J. Sprent. 2006. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311:1924-1927.
16. Gonzalez, A., I. Andre-Schmutz, C. Carnaud, D. Mathis, and C. Benoist. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat. Immunol. 2:1117-1125.
17. + regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 101 (Suppl. 2):14580-14585.
18. + cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion. J. Immunol. 173:2942-2951.
19. Eggena, M. P., L. S. Walker, V. Nagabhushanam, L. Barron, A. Chodos, and A. K. Abbas. 2004. Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen. J. Exp. Med. 199:1725-1730.
20. Bouaziz, J. D., K. Yanaba, G. M. Venturi, Y. Wang, R. M. Tisch, J. C. Poe, and T. F. Tedder. 2007. Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proc. Natl. Acad. Sci. USA 104:20878-20883.
21. Serreze, D. V., S. A. Fleming, H. D. Chapman, S. D. Richard, E. H. Leiter, and R. M. Tisch. 1998. B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J. Immunol. 161:3912-3918.
22. Falcone, M., J. Lee, G. Patstone, B. Yeung, and N. Sarvetnick. 1998. B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice. J. Immunol. 161:1163-1168.
23. Noorchashm, H., Y. K. Lieu, N. Noorchashm, S. Y. Rostami, S. A. Greeley, A. Schlachterman, H. K. Song, L. E. Noto, A. M. Jevnikar, C. F. Barker, and A. Naji. 1999. I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet β cells of nonobese diabetic mice. J. Immunol. 163:743-750.
24. Harbers, S. O., A. Crocker, G. Catalano, V. D'Agati, S. Jung, D. D. Desai, and R. Clynes. 2007. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J. Clin. Invest. 117:1361-1369.
25. Reijonen, H., T. L. Daniels, A. Lernmark, and G. T. Nepom. 2000. GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65. Diabetes 49:1621-1626.
26. + T cells. J. Exp. Med. 166:823-832.
27. Faustman, D. L., and M. Davis. 2009. The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies. J. Mol. Med. 87:1173-1178.
28. Savinov, A. Y., D. V. Rozanov, V. S. Golubkov, F. S. Wong, and A. Y. Strongin. 2005. Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas. J. Biol. Chem. 280:27755-27758.
29. Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238.
30. + T cell-mediated suppression by dendritic cells. Science 299:1033-1036.
31. Webster, K. E., S. Walters, R. E. Kohler, T. Mrkvan, O. Boyman, C. D. Surh, S. T. Grey, and J. Sprent. 2009. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J. Exp. Med. 206:751-760.
32. Tang, Q., J. Y. Adams, C. Penaranda, K. Melli, E. Piaggio, E. Sgouroudis, C. A. Piccirillo, B. L. Salomon, and J. A. Bluestone. 2008. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28:687-697.