Central Nervous System (CNS) delivery of glucocorticoids is fine-tuned by saturable transporters at the blood-CNS barriers and nonbarrier regions

Endocrinology

Volumn 151, Issue 11, 2010, Pages 5294-5305

  Mason, Brittany L ^a   Pariante, Carmine M ^a   Jamel, Sara ^a   Thomas, Sarah A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; DIGOXIN; GLYCOPROTEIN P; HYDROCORTISONE; ORGANIC ANION TRANSPORTER; TRITIUM; CARRIER PROTEIN; GLUCOCORTICOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CHOROID PLEXUS; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; HYPOTHALAMUS; MOUSE; NONHUMAN; PITUITARY GLAND EXAMINATION; PRIORITY JOURNAL; ANALYSIS OF VARIANCE; ANIMAL; MALE; METABOLISM; MOUSE MUTANT; TRANSPORT AT THE CELLULAR LEVEL;

ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CHOROID PLEXUS; CORTICOSTERONE; GLUCOCORTICOIDS; HYDROCORTISONE; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT;

EID: 78049488673     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0554     Document Type: Article

References (46)

1. Pariante CM, Lightman SL 2008 The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31:464-468
2. Holsboer F 2000 The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23:477-501
3. Snart RS, Wilson MJ 1967 Uptake of steroid hormones into artificial phospolipid/cholesterol membranes. Nature 215:964
4. Giorgi EP, Stein WD 1981 The transport of steroids into animal cells in culture. Endocrinology 108:688-697 (Pubitemid 11138690)
5. Gazzin S, Strazielle N, Schmitt C, Fevre-Montange M, Ostrow JD, Tiribelli C, Ghersi-Egea JF 2008 Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces. J Comp Neurol 510:497-507
6. Johanson CE, Duncan 3rd JA, Klinge PM, Brinker T, Stopa EG, Silverberg GD 2008 Multiplicity of cerebrospinal fluid functions: new challenges in health and disease. Cerebrospinal Fluid Res 5:10-41
7. Pardridge WM, Mietus LJ 1979 Transport of steroid hormones through the rat blood-brain barrier. J Clin Invest 64:145-154
8. Murphy BE, Cosgrove JB, McIlquham MC, Pattee CJ 1967 Adrenal corticoid levels in human cerebrospinal fluid. Can Med Assoc J 97:13-17
9. Lacko L, Wittke B, Geck P 1975 Interaction of steroids with the transport system of glucose in human erythrocytes. J Cell Physiol 86:673-680
10. Horner HC, Packan DR, Sapolsky RM 1990 Glucocorticoids inhibit glucose transport in cultured hippocampal neurons and glia. Neuroendocrinology 52:57-64
11. Virgin Jr CE, Ha TP, Packan DR, Tombaugh GC, Yang SH, Horner HC, Sapolsky RM 1991 Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity. J Neurochem 57:1422-1428
12. de Leon MJ, McRae T, Rusinek H, Convit A, De Santi S, Tarshish S, Golomb J, Volkow N, Daisley K, Orentreich N, McEwen B 1997 Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease. J Clin Endocrinol Metab 82:3251-3259
13. Mason BL, Pariante CM, Thomas SA 2008 A revised role for pglycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild type and abcb1a/b-deficient mice. Endocrinology 149:5244-5253
14. Yau JLW, Noble J, Thomas S, Kerwin R, Morgan PE, Lightman S, Seckl JR, Pariante CM 2007 The antidepressant desipramine requires the ABCB (mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice. Neuropsychopharmacology 32:1-10
15. Müller MB, Keck ME, Binder EB, Kresse AE, Hagenmeyer TP, Landgraf R, Holsboer F, Uhr M 2003 ABCB1 (MDR1)-type p-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder. Neuropsychopharmacology 28:1991-1999 (Pubitemid 37412108)
16. Bossuyt X, Müller M, Hagenbuch B, Meier PJ 1996 Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther 276:891-896
17. Béery E, Middel P, Bahn A, Willenberg HS, Hagos Y, Koepsell H, Bornstein SR, Müller GA, Burckhardt G, Steffgen J 2003 Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin- regulated zonal expression. Endocrinology 144:4519-4526
18. Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ 2000 Organic anion-transporting polypeptides mediate transport of opioid peptides across the blood-brain barrier. J Pharmacol Exp Ther 294:73-79
19. Gao B, Meier PJ 2001 Organic anion transport across the choroid plexus. Microsc Res Tech 52:60-64
20. Abe T, Kakyo M, Sakagami H, Tokui T, Nishio T, Tanemoto M, Nomura H, Hebert SC, Matsuno S, Kondo H, Yawo H 1998 Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem 273:22395-22401
21. van Montfoort JE, Schmid TE, Adler ID, Meier PJ, Hagenbuch B 2002 Functional characterization of the mouse organic-anion-transporting polypeptide 2. Biochem Biophys Acta 1564:183-188
22. Ohtsuki S, Takizawa T, Takanaga H, Hori S, Hosoya K, Terasaki T 2004 Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parachymal and capillary endothelial cells. J Neurochem 90:743-749
23. Yousif S, Marie-Claire C, Roux F, Scherrmann JM, Declèves X 2007 Expression of drug transporters at the blood-brain barrier using an optimized isolated rat brain microvessel strategy. Brain Res 1134:1-11
24. Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, Piwnica-Worms D 1999 Choroid plexus epithelial expression of MDR1 P-glycoprotein and multidrug resistance-associated preotein contribute to the blood-cerebrospinal-fluid drugpermeability barrier. Proc Natl Acad Sci USA 96:3900-3905
25. Karssen AM, Meijer OC, van der Sandt IC, Lucassen PJ, de Lange EC, de Boer AG, de Kloet ER 2001 Multidrug resistance p-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain. Endocrinology 142:2686-2694
26. Uhr M, Holsboer F, Müller MB 2002 Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b p-glycoproteins. J Neuroendocrinol 14:753-759
27. Sanderson L, Khan A, Thomas S 2007 Distribution of suramin, an antitrypanosomal drug, across the blood-brain and blood-cerebrospinal fluid interfaces in wild-type and P-glycoprotein transporter-deficient mice. Antimicrob Agents Chemother 51:3136-3146
28. Pariante CM, Kim RB, Makoff A, Kerwin RW 2003 Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulation membrane steroid transporters. Br J Pharmacol 139:1111-1118
29. Pariante CM, Hye A, Williamson R, Makoff A, Lovestone S, Kerwin RW 2003 The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones. Neuropsychopharmacology 28:1553-1561
30. Pariante CM, Thomas SA, Lovestone S, Makoff A, Kerwin RW 2004 Do antidepressants regulate how cortisol affects the brain? 2003 Curt Richter award paper. Psychoneuroendocrinology 29:423-447
31. Ito S, Koren G, Harper PA, Silverman M 1993 Energy-dependent transport of digoxin across renal tubular cell monolayers (LLCPK1). Can J Physiol Pharmacol 71:40-47
32. Li L, Meier PJ, Ballatori N 2000 Oatp2 mediates bidirectional organic solute transport: a role for intracellular gluthathione. Mol Pharmacol 58:335-340
33. Asaba H, Hosoya K, Takanaga H, Ohtsuki S, Tamura E, Takizawa T, Terasaki T 2000 Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2. J Neurochem 75:1907-1916
34. Baehr C, Reichel V, Fricker G 2006 Choroid plexus epithethial monolayers-a cell culture model from porcine brain. Cerebrospinal Fluid Res 3:13
35. 4) transfer from CSF to choroid plexus and ventricular brain regions in rabbit: contributory role of P-glycoprotein and organic anion transporting polypeptides. Brain Res 1181:44-50
36. Ritz V, Marwitz J, Sieder S, Ziemann C, Hirsch-Ernst KI, Quentin I, Steinfelder HJ 1999 Contribution of mdr1b-type p-glycoprotein to okadaic acid resistance in rat pituitary GH3 cells. Naunyn Schmiedebergs Arch Pharmacol 360:116-121
37. Tachibana O, Yamashima T, Yamashita J, Takabatake Y 1994 Immunohistochemical expression of human chorionic gonadotropin and p-glycoprotein in human pituitary glands and craniopharyngiomas. J Neurosurg 80:79-84
38. Raubenheimer PJ, Young EA, Andrew R, and Seckl JR 2006 The role of corticosterone in hypothalamic-pituitary-adrenal axis feedback. Clin Endocrinol (Oxf) 65:22-26
39. Orlowski S, Mir LM, Belehradek Jr J, Garrigos M 1996 Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Biochem J 317:515-522
40. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H 1999 Molecular cloning and characterization of a multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-13680
41. Steffgen J, Rohrbach S, Beery E, Ersoy D, Jarry H, Metten M, Bornstein SR, Müller GA, Burckhardt G 1999 Demonstration of a probenecid inhibitable anion exchanger involved in the release of cortisol and camp and in the uptake of p-amionhippurate in bovine adrenocortical cells. Cell Physiol Biochem 9:72-80
42. Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H 2001 Interactions of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol 281:F454-F468
43. 2 agonists by airway smooth muscle cells. J Allergy Clin Immunol 120:1103-1109
44. Holmes MC, Seckl JR 2006 The role of 11β-hydroxysteroid dehydrogenases in the brain. Mol Cell Endocrinol 248:9-14
45. Lightman SL, Wiles CC, Atkinson HC, Henley DE, Russell GM, Leendertz JA, McKenna MA, Spiga F, Wood SA, Conway-Campbell BL 2008 The significance of glucocorticoid pulsatility. Eur J Pharmacol 583:255-262
46. de Kloet ER, Derijk RH, Meijer OC 2007 Therapy insight: is there an imbalance response of mineralcorticoid and glucocorticoid receptors in depression? Nat Clin Pract Endocrinol Metab 3:168-179