Increased iron in HCV infection: Collateral damage or antiviral defense?

Journal of Hepatology

Volumn 53, Issue 6, 2010, Pages 990-992

  Mueller, Sebastian ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; NONSTRUCTURAL PROTEIN 5B; REACTIVE OXYGEN METABOLITE;

EDITORIAL; ENZYME INHIBITION; HEMOCHROMATOSIS; HEPATITIS C; HUMAN; INNATE IMMUNITY; IRON OVERLOAD; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPLICON; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; HEPATITIS C, CHRONIC; HUMANS; IRON; LIVER; MODELS, BIOLOGICAL;

EID: 78049483752     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.08.003     Document Type: Editorial

References (21)

1. C. Ko, N. Siddaiah, J. Berger, R. Gish, D. Brandhagen, and R.K. Sterling Prevalence of hepatic iron overload and association with hepatocellular cancer in end-stage liver disease: results from the National Hemochromatosis Transplant Registry Liver Int 27 2007 1394 1401
2. K.V. Kowdley Iron, hemochromatosis, and hepatocellular carcinoma Gastroenterology 127 2004 S79 S86
3. N. Fujita, R. Sugimoto, M. Takeo, N. Urawa, R. Mifuji, and H. Tanaka Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C Mol Med 13 2007 97 104
4. S. Nishina, K. Hino, M. Korenaga, C. Vecchi, A. Pietrangelo, and Y. Mizukami Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription Gastroenterology 134 2008 226 238
5. P.L. Lee, and E. Beutler Regulation of hepcidin and iron-overload disease Annu Rev Pathol 4 2009 489 515
6. E. Nemeth, and T. Ganz The role of hepcidin in iron metabolism Acta Haematol 122 2009 78 86
7. S. Hagist, H. Sultmann, G. Millonig, U. Hebling, D. Kieslich, and R. Kuner In vitro-targeted gene identification in patients with hepatitis C using a genome-wide microarray technology Hepatology 49 2009 378 386
8. C. Fillebeen, and K. Pantopoulos Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells J Hepatol 2010 995 999
9. C. Fillebeen, A.M. Rivas-Estilla, M. Bisaillon, P. Ponka, M. Muckenthaler, and M.W. Hentze Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C virus J Biol Chem 280 2005 9049 9057
10. C. Fillebeen, M. Muckenthaler, B. Andriopoulos, M. Bisaillon, Z. Mounir, and M.W. Hentze Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells J Hepatol 47 2007 12 22
11. H.L. Bonkovsky, D. Naishadham, R.W. Lambrecht, R.T. Chung, J.C. Hoefs, and S.R. Nash Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C Gastroenterology 131 2006 1440 1451
12. S. Distante, K. Bjoro, K.B. Hellum, B. Myrvang, J.P. Berg, and K. Skaug Raised serum ferritin predicts non-response to interferon and ribavirin treatment in patients with chronic hepatitis C infection Liver 22 2002 269 275
13. P. Lebray, H. Zylberberg, S. Hue, B. Poulet, F. Carnot, and S. Martin Influence of HFE gene polymorphism on the progression and treatment of chronic hepatitis C J Viral Hepat 11 2004 175 182
14. U.E. Schaible, and S.H. Kaufmann Iron and microbial infection Nat Rev Microbiol 2 2004 946 953
15. P. Harmatz, M.M. Jonas, J.L. Kwiatkowski, E.C. Wright, R. Fischer, and E. Vichinsky Safety and efficacy of pegylated interferon alpha-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia Haematologica 93 2008 1247 1251
16. S. Kahraman, R. Yilmaz, G. Genctoy, M. Arici, B. Altun, and Y. Erdem Efficacy and safety of intravenous iron therapy for HCV-positive haemodialysis patients Nephron Clin Pract 100 2005 c78 c85
17. J. Kato, M. Kobune, T. Nakamura, G. Kuroiwa, K. Takada, and R. Takimoto Normalization of elevated hepatic 8-hydroxy-2′-deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet Cancer Res 61 2001 8697 8702
18. A.M. Di Bisceglie, H.L. Bonkovsky, S. Chopra, S. Flamm, R.K. Reddy, and N. Grace Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: a multicenter, prospective, randomized, controlled trial Hepatology 32 2000 135 138
19. S. Mueller, K. Pantopoulos, C.A. Hübner, W. Stremmel, and M.W. Hentze IRP1 activation by extracellular oxidative stress in the perfused rat liver J Biol Chem 276 2001 23192 23196
20. K. Miura, K. Taura, Y. Kodama, B. Schnabl, and D.A. Brenner Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity Hepatology 48 2008 1420 1429
21. B. Andriopoulos, S. Hegedusch, J. Mangin, H.D. Riedel, U. Hebling, and J. Wang Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network J Biol Chem 282 2007 20301 20308