Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells

Journal of Hepatology

Volumn 53, Issue 6, 2010, Pages 995-999

  Fillebeen, Carine ^a   Pantopoulos, Kostas ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Ferritin; Hepatitis C virus; Iron metabolism; NS3; NS5B; Transferrin receptor 1

Indexed keywords

CORE PROTEIN; IRON; IRON SALICYLALDEHYDE ISONICOTINOYL HYDRAZONE; NONSTRUCTURAL PROTEIN 5B; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; HEPATITIS C; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPLICON;

ALDEHYDES; ANTIVIRAL AGENTS; CELL LINE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; HYDRAZONES; IRON; VIRUS REPLICATION;

EID: 78049455727     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.04.044     Document Type: Article

References (41)

1. V. Alla, and H.L. Bonkovsky Iron in nonhemochromatotic liver disorders Semin Liver Dis 25 2005 461 472
2. N.C. Andrews Disorders of iron metabolism N Engl J Med 341 1999 1986 1995
3. H.L. Bonkovsky, D. Naishadham, R.W. Lambrecht, R.T. Chung, J.C. Hoefs, and S.R. Nash Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C Gastroenterology 131 2006 1440 1451
4. Buss JL, Hermes-Lima M, Ponka P. Pyridoxal isonicotinoyl hydrazone and its analogues. In: Hershko C, editors. Progress in iron research, vol. 509; 2002. p. 205-29.
5. S.F. de Almeida, I.F. Carvalho, C.S. Cardoso, J.V. Cordeiro, J.E. Azevedo, and J. Neefjes HFE cross-talks with the MHC class I antigen presentation pathway Blood 106 2005 971 977
6. S. Distante, K. Bjoro, K.B. Hellum, B. Myrvang, J.P. Berg, and K. Skaug Raised serum ferritin predicts non-response to interferon and ribavirin treatment in patients with chronic hepatitis C infection Liver 22 2002 269 275
7. C. Fillebeen, M. Muckenthaler, B. Andriopoulos, M. Bisaillon, Z. Mounir, and M.W. Hentze Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells J Hepatol 47 2007 12 22
8. C. Fillebeen, A.M. Rivas-Estilla, M. Bisaillon, P. Ponka, M. Muckenthaler, and M.W. Hentze Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C virus J Biol Chem 280 2005 9049 9057
9. N. Fujita, R. Sugimoto, M. Takeo, N. Urawa, R. Mifuji, and H. Tanaka Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C Mol Med 13 2007 97 104
10. P. Harmatz, M.M. Jonas, J.L. Kwiatkowski, E.C. Wright, R. Fischer, and E. Vichinsky Safety and efficacy of pegylated interferon alpha-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia Haematologica 93 2008 1247 1251
11. H.C. Isom, E.I. McDevitt, and M.S. Moon Elevated hepatic iron: a confounding factor in chronic hepatitis C Biochim Biophys Acta 1790 2009 650 662
12. S. Kahraman, R. Yilmaz, G. Genctoy, M. Arici, B. Altun, and Y. Erdem Efficacy and safety of intravenous iron therapy for HCV-positive haemodialysis patients Nephron Clin Pract 100 2005 c78 c85
13. T. Kato, T. Date, A. Murayama, K. Morikawa, D. Akazawa, and T. Wakita Cell culture and infection system for hepatitis C virus Nat Protoc 1 2006 2334 2339
14. K.V. Kowdley Iron, hemochromatosis, and hepatocellular carcinoma Gastroenterology 127 2004 S79 S86
15. D. Lavanchy The global burden of hepatitis C Liver Int 29 2009 74 81
16. P. Lebray, H. Zylberberg, S. Hue, B. Poulet, F. Carnot, and S. Martin Influence of HFE gene polymorphism on the progression and treatment of chronic hepatitis C J Viral Hepat 11 2004 175 182
17. P.L. Lee, and E. Beutler Regulation of hepcidin and iron-overload disease Annu Rev Pathol 4 2009 489 515
18. E. Lehmann, W.H. El-Tantawy, M. Ocker, R. Bartenschlager, V. Lohmann, and S. Hashemolhosseini The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response Hepatology 51 2010 398 404
19. K. Miura, K. Taura, Y. Kodama, B. Schnabl, and D.A. Brenner Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity Hepatology 48 2008 1420 1429
20. S. Mueller, N.H. Afdhal, and D. Schuppan Iron, HCV, and liver cancer: hard metal setting the pace? Gastroenterology 130 2006 2229 2234
21. E. Nemeth, and T. Ganz The role of hepcidin in iron metabolism Acta Haematol 122 2009 78 86
22. S. Nishina, K. Hino, M. Korenaga, C. Vecchi, A. Pietrangelo, and Y. Mizukami Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription Gastroenterology 134 2008 226 238
23. J. Paeshuyse, L. Coelmont, I. Vliegen, J.V. Hemel, J. Vandenkerckhove, and E. Peys Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin Biochem Biophys Res Commun 348 2006 139 144
24. K. Pantopoulos Iron metabolism and the IRE/IRP regulatory system: an update Ann NY Acad Sci 1012 2004 1 13
25. A. Pietrangelo Hemochromatosis gene modifies course of hepatitis C viral infection Gastroenterology 124 2003 1509 1523
26. A. Pietrangelo Hereditary hemochromatosis - a new look at an old disease N Engl J Med 350 2004 2383 2397
27. A. Pietrangelo Metals, oxidative stress, and hepatic fibrogenesis Semin Liver Dis 16 1996 13 30
28. P. Ponka, and H.M. Schulman Acquisition of iron from transferrin regulates reticulocyte heme synthesis J Biol Chem 260 1985 14717 14721
29. S.W. Ryter, J. Alam, and A.M. Choi Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications Physiol Rev 86 2006 583 650
30. U.E. Schaible, and S.H. Kaufmann Iron and microbial infection Nat Rev Microbiol 2 2004 946 953
31. G. Sebastiani, and A.P. Walker HFE gene in primary and secondary hepatic iron overload World J Gastroenterol 13 2007 4673 4689
32. L.B. Seeff The history of the "natural history" of hepatitis C (1968-2009) Liver Int 29 2009 89 99
33. Y. Shan, J. Zheng, R.W. Lambrecht, and H.L. Bonkovsky Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes Gastroenterology 133 2007 1166 1174
34. T. Takeuchi, A. Katsume, T. Tanaka, A. Abe, K. Inoue, and K. Tsukiyama-Kohara Real-time detection system for quantification of hepatitis C virus genome Gastroenterology 116 1999 636 642 (Pubitemid 29106771)
35. T. Wakita, T. Pietschmann, T. Kato, T. Date, M. Miyamoto, and Z. Zhao Production of infectious hepatitis C virus in tissue culture from a cloned viral genome Nat Med 11 2005 791 796
36. L. Wang, L. Harrington, E. Trebicka, H.N. Shi, J.C. Kagan, and C.C. Hong Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice J Clin Invest 119 2009 3322 3328
37. G. Weiss Iron and immunity: a double-edged sword Eur J Clin Invest 32 2002 70 78
38. G. Weiss, F. Umlauft, M. Urbanek, M. Herold, M. Loyevsky, and F. Offner Associations between cellular immune effector function, iron metabolism, and disease activity in patients with chronic hepatitis C virus infection J Infect Dis 180 1999 1452 1458
39. G. Weiss, G. Werner-Felmayer, E.R. Werner, K. Grünewald, H. Wachter, and M.W. Hentze Iron regulates nitric oxide synthase activity by controlling nuclear transcription J Exp Med 180 1994 969 976
40. J. Zhong, P. Gastaminza, G. Cheng, S. Kapadia, T. Kato, and D.R. Burton Robust hepatitis C virus infection in vitro Proc Natl Acad Sci USA 102 2005 9294 9299
41. Z. Zhu, A.T. Wilson, M.M. Mathahs, F. Wen, K.E. Brown, and B.A. Luxon Heme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury Hepatology 48 2008 1430 1439