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Volumn 17, Issue 11, 2010, Pages 3043-3052

Osteopontin expression is an independent adverse prognostic factor in resectable gastrointestinal stromal tumor and its interaction with CD44 promotes tumor proliferation

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; OSTEOPONTIN;

EID: 78049477292     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-010-1143-8     Document Type: Article
Times cited : (17)

References (41)
  • 4
    • 62849096370 scopus 로고    scopus 로고
    • American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: A randomised, double-blind, placebo-controlled trial
    • 1:CAS:528:DC%2BD1MXjslOltro%3D 10.1016/S0140-6736(09)60500-6 19303137
    • RP Dematteo KV Ballman CR Antonescu, et al. 2009 American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial Lancet. 373 1097 1104 1:CAS:528:DC%2BD1MXjslOltro%3D 10.1016/S0140-6736(09)60500-6 19303137
    • (2009) Lancet. , vol.373 , pp. 1097-1104
    • Dematteo, R.P.1    Ballman, K.V.2    Antonescu, C.R.3
  • 5
    • 4644312266 scopus 로고    scopus 로고
    • Biology of gastrointestinal stromal tumors
    • DOI 10.1200/JCO.2004.05.140
    • CL Corless JA Fletcher MC Heinrich 2004 Biology of gastrointestinal stromal tumors J Clin Oncol. 22 3813 3825 1:CAS:528:DC%2BD2cXhtVCitb%2FL 10.1200/JCO.2004.05.140 15365079 (Pubitemid 41095223)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.18 , pp. 3813-3825
    • Corless, C.L.1    Fletcher, J.A.2    Heinrich, M.C.3
  • 6
    • 70349463111 scopus 로고    scopus 로고
    • Biomarkers in GIST: Partly ready for prime-time use
    • 1:CAS:528:DC%2BD1MXhtFars7%2FL 10.1158/1078-0432.CCR-09-1563 19737947
    • CD Blanke 2009 Biomarkers in GIST: partly ready for prime-time use Clin Cancer Res. 15 5603 5605 1:CAS:528:DC%2BD1MXhtFars7%2FL 10.1158/1078-0432.CCR- 09-1563 19737947
    • (2009) Clin Cancer Res. , vol.15 , pp. 5603-5605
    • Blanke, C.D.1
  • 8
    • 0018426687 scopus 로고
    • Transformed mammalian cells secrete specific proteins and phosphoproteins
    • 1:CAS:528:DyaE1MXktFyjsb0%3D 10.1016/0092-8674(79)90103-X 88265
    • DR Senger DF Wirth RO Hynes 1979 Transformed mammalian cells secrete specific proteins and phosphoproteins Cell. 16 885 893 1:CAS:528: DyaE1MXktFyjsb0%3D 10.1016/0092-8674(79)90103-X 88265
    • (1979) Cell. , vol.16 , pp. 885-893
    • Senger, D.R.1    Wirth, D.F.2    Hynes, R.O.3
  • 9
    • 0027131418 scopus 로고
    • Osteopontin: A protein with diverse functions
    • 1:CAS:528:DyaK2cXkvVaiug%3D%3D 8262332
    • DT Denhardt X Guo 1993 Osteopontin: a protein with diverse functions FASEB J. 7 1475 1482 1:CAS:528:DyaK2cXkvVaiug%3D%3D 8262332
    • (1993) FASEB J. , vol.7 , pp. 1475-1482
    • Denhardt, D.T.1    Guo, X.2
  • 10
    • 0035021027 scopus 로고    scopus 로고
    • Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival
    • 1:CAS:528:DC%2BD3MXjsVCjtL0%3D 10.1172/JCI12980 11342566
    • DT Denhardt M Noda AW O'Regan D Pavlin JS Berman 2001 Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival J Clin Invest. 107 1055 1061 1:CAS:528: DC%2BD3MXjsVCjtL0%3D 10.1172/JCI12980 11342566
    • (2001) J Clin Invest. , vol.107 , pp. 1055-1061
    • Denhardt, D.T.1    Noda, M.2    O'Regan, A.W.3    Pavlin, D.4    Berman, J.S.5
  • 11
    • 32644467590 scopus 로고    scopus 로고
    • Osteopontin: Role in cell signaling and cancer progression
    • DOI 10.1016/j.tcb.2005.12.005, PII S0962892405003132
    • H Rangaswami A Bulbule GC Kundu 2006 Osteopontin: role in cell signaling and cancer progression Trends Cell Biol. 16 79 87 1:CAS:528:DC%2BD28XhsFOjsbc%3D 10.1016/j.tcb.2005.12.005 16406521 (Pubitemid 43247403)
    • (2006) Trends in Cell Biology , vol.16 , Issue.2 , pp. 79-87
    • Rangaswami, H.1    Bulbule, A.2    Kundu, G.C.3
  • 12
    • 1642576134 scopus 로고    scopus 로고
    • Correlation of Osteopontin Protein Expression and Pathological Stage across a Wide Variety of Tumor Histologies
    • DOI 10.1158/1078-0432.CCR-1405-2
    • D Coppola M Szabo D Boulware, et al. 2004 Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies Clin Cancer Res. 10 184 190 1:CAS:528:DC%2BD2cXkvF2msg%3D%3D 10.1158/1078-0432.CCR-1405-2 14734468 (Pubitemid 38114178)
    • (2004) Clinical Cancer Research , vol.10 , Issue.1 I , pp. 184-190
    • Coppola, D.1    Szabo, M.2    Boulware, D.3    Muraca, P.4    Alsarraj, M.5    Chambers, A.F.6    Yeatman, T.J.7
  • 13
    • 2942511574 scopus 로고    scopus 로고
    • Role of osteopontin in tumour progression
    • DOI 10.1038/sj.bjc.6601839
    • SR Rittling AF Chambers 2004 Role of osteopontin in tumour progression Br J Cancer. 90 1877 1881 1:CAS:528:DC%2BD2cXjvVals7g%3D 10.1038/sj.bjc.6601839 15138464 (Pubitemid 38746324)
    • (2004) British Journal of Cancer , vol.90 , Issue.10 , pp. 1877-1881
    • Rittling, S.R.1    Chambers, A.F.2
  • 14
    • 64049117132 scopus 로고    scopus 로고
    • Tumorigenic properties of alternative OPN isoforms in mesothelioma
    • 1:CAS:528:DC%2BD1MXksVCntbc%3D 10.1016/j.bbrc.2009.03.042 19285954
    • SV Ivanov AV Ivanova CM Goparaju Y Chen A Beck HI Pass 2009 Tumorigenic properties of alternative OPN isoforms in mesothelioma Biochem Biophys Res Commun. 382 514 518 1:CAS:528:DC%2BD1MXksVCntbc%3D 10.1016/j.bbrc.2009.03.042 19285954
    • (2009) Biochem Biophys Res Commun. , vol.382 , pp. 514-518
    • Ivanov, S.V.1    Ivanova, A.V.2    Goparaju, C.M.3    Chen, Y.4    Beck, A.5    Pass, H.I.6
  • 15
    • 34547885530 scopus 로고    scopus 로고
    • An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma
    • DOI 10.1038/sj.onc.1210463, PII 1210463
    • V Takafuji M Forgues E Unsworth P Goldsmith XW Wang 2007 An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma Oncogene. 26 6361 6371 1:CAS:528:DC%2BD2sXhtV2is73K 10.1038/sj.onc.1210463 17452979 (Pubitemid 47494216)
    • (2007) Oncogene , vol.26 , Issue.44 , pp. 6361-6371
    • Takafuji, V.1    Forgues, M.2    Unsworth, E.3    Goldsmith, P.4    Wang, X.W.5
  • 16
    • 51249084799 scopus 로고    scopus 로고
    • Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis
    • 1:CAS:528:DC%2BD1cXhtFylsrnN 10.1053/j.gastro.2008.05.025 18555021
    • J Zhao L Dong B Lu, et al. 2008 Down-regulation of osteopontin suppresses growth and metastasis of hepatocellular carcinoma via induction of apoptosis Gastroenterology. 135 956 968 1:CAS:528:DC%2BD1cXhtFylsrnN 10.1053/j.gastro. 2008.05.025 18555021
    • (2008) Gastroenterology. , vol.135 , pp. 956-968
    • Zhao, J.1    Dong, L.2    Lu, B.3
  • 17
    • 0030064334 scopus 로고    scopus 로고
    • Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
    • 1:CAS:528:DyaK28XmvFyrtA%3D%3D 10.1126/science.271.5248.509 8560266
    • GF Weber S Ashkar MJ Glimcher H Cantor 1996 Receptor-ligand interaction between CD44 and osteopontin (Eta-1) Science. 271 509 512 1:CAS:528: DyaK28XmvFyrtA%3D%3D 10.1126/science.271.5248.509 8560266
    • (1996) Science. , vol.271 , pp. 509-512
    • Weber, G.F.1    Ashkar, S.2    Glimcher, M.J.3    Cantor, H.4
  • 18
    • 0030941056 scopus 로고    scopus 로고
    • Interaction between CD44 and osteopontin as a potential basis for metastasis formation
    • 1:CAS:528:DyaK2sXhtVemtLk%3D 9010911
    • GF Weber S Ashkar H Cantor 1997 Interaction between CD44 and osteopontin as a potential basis for metastasis formation Proc Assoc Am Physicians. 109 1 9 1:CAS:528:DyaK2sXhtVemtLk%3D 9010911
    • (1997) Proc Assoc Am Physicians. , vol.109 , pp. 1-9
    • Weber, G.F.1    Ashkar, S.2    Cantor, H.3
  • 19
    • 0035966343 scopus 로고    scopus 로고
    • The metastasis gene osteopontin: A candidate target for cancer therapy
    • 1:CAS:528:DC%2BD38XhsFahs74%3D 11825687
    • GF Weber 2001 The metastasis gene osteopontin: a candidate target for cancer therapy Biochim Biophys Acta. 1552 61 85 1:CAS:528:DC%2BD38XhsFahs74%3D 11825687
    • (2001) Biochim Biophys Acta. , vol.1552 , pp. 61-85
    • Weber, G.F.1
  • 20
    • 0035671826 scopus 로고    scopus 로고
    • Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer
    • 1:CAS:528:DC%2BD38XltFSitA%3D%3D 11751502
    • NS Fedarko A Jain A Karadag MR Van Eman LW Fisher 2001 Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer Clin Cancer Res. 7 4060 4066 1:CAS:528:DC%2BD38XltFSitA%3D%3D 11751502
    • (2001) Clin Cancer Res. , vol.7 , pp. 4060-4066
    • Fedarko, N.S.1    Jain, A.2    Karadag, A.3    Van Eman, M.R.4    Fisher, L.W.5
  • 21
    • 0037012469 scopus 로고    scopus 로고
    • Osteopontin as a potential diagnostic biomarker for ovarian cancer
    • 1:CAS:528:DC%2BD38XisFaru7k%3D 10.1001/jama.287.13.1671 11926891
    • JH Kim SJ Skates T Uede, et al. 2002 Osteopontin as a potential diagnostic biomarker for ovarian cancer JAMA. 287 1671 1679 1:CAS:528: DC%2BD38XisFaru7k%3D 10.1001/jama.287.13.1671 11926891
    • (2002) JAMA , vol.287 , pp. 1671-1679
    • Kim, J.H.1    Skates, S.J.2    Uede, T.3
  • 22
    • 77949890243 scopus 로고    scopus 로고
    • Reduction of elevated plasma osteopontin levels with resection of non-small-cell lung cancer
    • 1:CAS:528:DC%2BC3cXktF2lsbc%3D 10.1200/JCO.2009.25.5711 20085934
    • JD Blasberg HI Pass CM Goparaju RM Flores S Lee JS Donington 2010 Reduction of elevated plasma osteopontin levels with resection of non-small-cell lung cancer J Clin Oncol. 28 936 941 1:CAS:528:DC%2BC3cXktF2lsbc%3D 10.1200/JCO.2009.25.5711 20085934
    • (2010) J Clin Oncol. , vol.28 , pp. 936-941
    • Blasberg, J.D.1    Pass, H.I.2    Goparaju, C.M.3    Flores, R.M.4    Lee, S.5    Donington, J.S.6
  • 23
    • 36349004675 scopus 로고    scopus 로고
    • Prognostic significance of osteopontin expression in human gastric carcinoma
    • DOI 10.1245/s10434-007-9564-8
    • M Higashiyama T Ito E Tanaka Y Shimada 2007 Prognostic significance of osteopontin expression in human gastric carcinoma Ann Surg Oncol. 14 3419 3427 10.1245/s10434-007-9564-8 17896150 (Pubitemid 350160128)
    • (2007) Annals of Surgical Oncology , vol.14 , Issue.12 , pp. 3419-3427
    • Higashiyama, M.1    Ito, T.2    Tanaka, E.3    Shimada, Y.4
  • 24
    • 37049008878 scopus 로고    scopus 로고
    • Protein expression of osteopontin in tumor tissues is an independent prognostic indicator in gastric cancer
    • DOI 10.1159/000111108
    • N Dai Q Bao A Lu J Li 2007 Protein expression of osteopontin in tumor tissues is an independent prognostic indicator in gastric cancer Oncology. 72 89 96 1:CAS:528:DC%2BD2sXhtlyksLrK 10.1159/000111108 18004082 (Pubitemid 350249135)
    • (2007) Oncology , vol.72 , Issue.1-2 , pp. 89-96
    • Dai, N.1    Bao, Q.2    Lu, A.3    Li, J.4
  • 26
    • 34249775191 scopus 로고    scopus 로고
    • Elevated plasma osteopontin associated with gastric cancer development, invasion and survival
    • DOI 10.1136/gut.2006.109868
    • CY Wu MS Wu EP Chiang, et al. 2007 Elevated plasma osteopontin associated with gastric cancer development, invasion and survival Gut. 56 782 789 1:CAS:528:DC%2BD2sXoslKisLc%3D 10.1136/gut.2006.109868 17148500 (Pubitemid 46854191)
    • (2007) Gut , vol.56 , Issue.6 , pp. 782-789
    • Wu, C.-Y.1    Wu, M.-S.2    Chiang, E.-P.3    Wu, C.-C.4    Chen, Y.-J.5    Chen, C.-J.6    Chi, N.-H.7    Chen, G.-H.8    Lin, J.-T.9
  • 27
    • 55949125559 scopus 로고    scopus 로고
    • Overexpression of osteopontin independently correlates with vascular invasion and poor prognosis in patients with hepatocellular carcinoma
    • 1:CAS:528:DC%2BD1cXhtlyltb%2FF 10.1016/j.humpath.2008.05.006 18701136
    • PV Korita T Wakai Y Shirai, et al. 2008 Overexpression of osteopontin independently correlates with vascular invasion and poor prognosis in patients with hepatocellular carcinoma Hum Pathol. 39 1777 1783 1:CAS:528: DC%2BD1cXhtlyltb%2FF 10.1016/j.humpath.2008.05.006 18701136
    • (2008) Hum Pathol. , vol.39 , pp. 1777-1783
    • Korita, P.V.1    Wakai, T.2    Shirai, Y.3
  • 28
    • 0034093124 scopus 로고    scopus 로고
    • Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration
    • 1:CAS:528:DC%2BD3cXjvFynu7w%3D 10.1002/(SICI)1097-4652(200007)184: 1<118::AID-JCP13>3.0.CO;2-Y 10825241
    • R Zohar N Suzuki K Suzuki, et al. 2000 Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration J Cell Physiol. 184 118 130 1:CAS:528:DC%2BD3cXjvFynu7w%3D 10.1002/(SICI)1097- 4652(200007)184:1<118::AID-JCP13>3.0.CO;2-Y 10825241
    • (2000) J Cell Physiol. , vol.184 , pp. 118-130
    • Zohar, R.1    Suzuki, N.2    Suzuki, K.3
  • 29
    • 0035824560 scopus 로고    scopus 로고
    • The osteopontin-CD44 survival signal involves activation of the PI3 K/Akt signaling pathway
    • 1:CAS:528:DC%2BD3MXptVymsb8%3D 10.1074/jbc.M105132200 11590166
    • YH Lin HF Yang-Yen 2001 The osteopontin-CD44 survival signal involves activation of the PI3 K/Akt signaling pathway J Biol Chem. 276 46024 46030 1:CAS:528:DC%2BD3MXptVymsb8%3D 10.1074/jbc.M105132200 11590166
    • (2001) J Biol Chem. , vol.276 , pp. 46024-46030
    • Lin, Y.H.1    Yang-Yen, H.F.2
  • 30
    • 13244284603 scopus 로고    scopus 로고
    • Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12
    • DOI 10.1038/sj.onc.1208209
    • H Teramoto MD Castellone RL Malek, et al. 2005 Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12 Oncogene. 24 489 501 1:CAS:528:DC%2BD2MXnsFShuw%3D%3D 10.1038/sj.onc.1208209 15516973 (Pubitemid 40188596)
    • (2005) Oncogene , vol.24 , Issue.3 , pp. 489-501
    • Teramoto, H.1    Castellone, M.D.2    Malek, R.L.3    Letwin, N.4    Frank, B.5    Gutkind, J.S.6    Lee, N.H.7
  • 31
    • 33947413459 scopus 로고    scopus 로고
    • Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells
    • DOI 10.1186/1476-4598-6-18
    • B Desai MJ Rogers MA Chellaiah 2007 Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells Mol Cancer. 6 18 10.1186/1476-4598-6-18 17343740 (Pubitemid 46443394)
    • (2007) Molecular Cancer , vol.6 , pp. 18
    • Desai, B.1    Rogers, M.J.2    Chellaiah, M.A.3
  • 32
    • 77954958029 scopus 로고    scopus 로고
    • Clinical implication and mitotic effect of CD44 cleavage in relation to Osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor
    • doi:10.1245/s10434-010-0927-1 [Online February 10, 2010]
    • Hsu KH, Tsai HW, Lin PW, Hsu YS, Shan YS, Lu PJ. Clinical implication and mitotic effect of CD44 cleavage in relation to Osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor. Ann Surg Oncol. doi: 10.1245/s10434-010-0927-1 [Online February 10, 2010].
    • Ann Surg Oncol
    • Hsu, K.H.1    Tsai, H.W.2    Lin, P.W.3    Hsu, Y.S.4    Shan, Y.S.5    Lu, P.J.6
  • 35
    • 71449088757 scopus 로고    scopus 로고
    • Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localized primary gastrointestinal stromal tumour: A retrospective analysis
    • 10.1016/S1470-2045(09)70242-6 19793678
    • JS Gold M Gönen A Gutiérrez, et al. 2009 Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localized primary gastrointestinal stromal tumour: a retrospective analysis Lancet Oncol. 10 1045 1052 10.1016/S1470-2045(09)70242-6 19793678
    • (2009) Lancet Oncol. , vol.10 , pp. 1045-1052
    • Gold, J.S.1    Gönen, M.2    Gutiérrez, A.3
  • 36
    • 50649085726 scopus 로고    scopus 로고
    • Risk stratification of patients diagnosed with gastrointestinal stromal tumor
    • 10.1016/j.humpath.2008.06.025 18774375
    • H Joensuu 2008 Risk stratification of patients diagnosed with gastrointestinal stromal tumor Hum Pathol. 39 1411 1419 10.1016/j.humpath.2008. 06.025 18774375
    • (2008) Hum Pathol. , vol.39 , pp. 1411-1419
    • Joensuu, H.1
  • 37
    • 37549017616 scopus 로고    scopus 로고
    • Hypoxic osteocytes recruit human MSCs through an OPN/CD44-mediated pathway
    • 1:CAS:528:DC%2BD1cXislygsQ%3D%3D 10.1016/j.bbrc.2007.12.076 18155656
    • LF Raheja DC Genetos CE Yellowley 2008 Hypoxic osteocytes recruit human MSCs through an OPN/CD44-mediated pathway Biochem Biophys Res Commun. 366 1061 1066 1:CAS:528:DC%2BD1cXislygsQ%3D%3D 10.1016/j.bbrc.2007.12.076 18155656
    • (2008) Biochem Biophys Res Commun. , vol.366 , pp. 1061-1066
    • Raheja, L.F.1    Genetos, D.C.2    Yellowley, C.E.3
  • 38
    • 70349484248 scopus 로고    scopus 로고
    • Intermittent high glucose enhances proliferation of vascular smooth muscle cells by upregulating osteopontin
    • 1:CAS:528:DC%2BD1MXht1WqurvN 10.1016/j.mce.2009.08.019 19723557
    • J Sun Y Xu Z Dai Y Sun 2009 Intermittent high glucose enhances proliferation of vascular smooth muscle cells by upregulating osteopontin Mol Cell Endocrinol. 313 64 69 1:CAS:528:DC%2BD1MXht1WqurvN 10.1016/j.mce.2009.08. 019 19723557
    • (2009) Mol Cell Endocrinol. , vol.313 , pp. 64-69
    • Sun, J.1    Xu, Y.2    Dai, Z.3    Sun, Y.4
  • 39
    • 33947254565 scopus 로고    scopus 로고
    • V interaction enhances survival in gastrointestinal cancer cells
    • DOI 10.1158/0008-5472.CAN-06-3625
    • JL Lee MJ Wang PR Sudhir GD Chen CW Chi JY Chen 2007 Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44 V interaction enhances survival in gastrointestinal cancer cells Cancer Res. 67 2089 2097 1:CAS:528:DC%2BD2sXitlSjsr8%3D 10.1158/0008-5472.CAN-06-3625 17332338 (Pubitemid 46424227)
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 2089-2097
    • Lee, J.-L.1    Wang, M.-J.2    Sudhir, P.-R.3    Chen, G.-D.4    Chi, C.-W.5    Chen, J.-Y.6
  • 40
    • 76249122104 scopus 로고    scopus 로고
    • Characterization of the expression of variant and standard CD44 in prostate cancer cells: Identification of the possible molecular mechanism of CD44/MMP9 complex formation on the cell surface
    • 1:CAS:528:DC%2BD1MXhtVGju7rO 10.1002/jcb.22248 19582779
    • B Desai T Ma J Zhu MA Chellaiah 2009 Characterization of the expression of variant and standard CD44 in prostate cancer cells: identification of the possible molecular mechanism of CD44/MMP9 complex formation on the cell surface J Cell Biochem. 108 272 284 1:CAS:528:DC%2BD1MXhtVGju7rO 10.1002/jcb.22248 19582779
    • (2009) J Cell Biochem. , vol.108 , pp. 272-284
    • Desai, B.1    Ma, T.2    Zhu, J.3    Chellaiah, M.A.4
  • 41
    • 70449701416 scopus 로고    scopus 로고
    • Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells
    • 1:CAS:528:DC%2BD1MXhsV2lurjP 10.1016/j.yexcr.2009.10.012 19850036
    • BW Robertson MA Chellaiah 2010 Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells Exp Cell Res. 316 1 11 1:CAS:528:DC%2BD1MXhsV2lurjP 10.1016/j.yexcr.2009.10.012 19850036
    • (2010) Exp Cell Res. , vol.316 , pp. 1-11
    • Robertson, B.W.1    Chellaiah, M.A.2


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