Mitochondrially localized EGFR is independent of its endocytosis and associates with cell viability

Acta Biochimica et Biophysica Sinica

Volumn 42, Issue 11, 2010, Pages 763-770

  Yao, Yuan ^a   Wang, Gang ^a,b   Li, Zhe ^a   Yan, Bing ^a,b   Guo, Yinglu ^a,b   Jiang, Xuejun ^c   Xi, Zhijun ^a,b  

^a PEKING UNIVERSITY   (China)

^b NATIONAL UROLOGICAL CANCER CENTER   (China)

^c INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

cell viability; endocytosis; epidermal growth factor receptor; gefitinib; mitochondria

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ETOPOSIDE; GEFITINIB; GREEN FLUORESCENT PROTEIN; MITOCHONDRIAL PROTEIN; QUINAZOLINE DERIVATIVE;

ANIMAL; APOPTOSIS; ARTICLE; CELL LINE; CELL SURVIVAL; DRUG EFFECT; ENDOCYTOSIS; GENETICS; HUMAN; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; METABOLISM; MITOCHONDRION; MUTATION; PROTEIN TRANSPORT; TUMOR CELL LINE; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; ENDOCYTOSIS; EPIDERMAL GROWTH FACTOR; ETOPOSIDE; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOBLOTTING; MICROSCOPY, IMMUNOELECTRON; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; PROTEIN TRANSPORT; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 78049462907     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmq090     Document Type: Article

References (30)

1. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000, 103:211-225.
2. Waterman H and Yarden Y. Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett 2001, 490:142-152.
3. Beguinot L, Lyall RM, Willingham MC and Pastan I. Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes. Proc Natl Acad Sci USA 1984, 81:2384-2388.
4. Sorkin A and Waters CM. Endocytosis of growth factor receptors. Bioessays 1993, 15:375-382.
5. Carpentier JL, Rees AR, Gregoriou M, Kris R, Schlessinger J and Orci L. Subcellular distribution of the external and internal domains of the EGF receptor in A-431 cells. Exp Cell Res 1986, 166:312-326.
6. Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY and Bourguignon L, et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 2001, 3:802-808.
7. Boerner JL, Demory ML, Silva C and Parsons SJ. Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial proteincytochromecoxidase subunit II. Mol Cell Biol 2004, 24:7059-7071.
8. Yue X, Song W, Zhang W, Chen L, Xi Z, Xin Z and Jiang X. Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survival. Autophagy 2008, 4:641-649.
9. Casalini P, Iorio MV, Galmozzi E, and Menard S. Roleof HER receptorsfamily indevelopment and differentiation. J Cell Physiol 2004, 200:343-350
10. Tikhomirov O and Carpenter G. Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2. J Biol Chem 2004, 279:12988-12996.
11. Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ and Hung MC. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 2008, 13:385-393.
12. Bonawitz ND, Clayton DA and Shadel GS. Initiation and beyond: multiple functions of the human mitochondrial transcription machinery. Mol Cell 2006, 24:813-825.
13. Goldenthal MJ and Marin-Garcia J. Mitochondrial signaling pathways: a receiver/integrator organelle. Mol Cell Biochem 2004, 262:1-16.
14. Newmeyer DD and Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 2003, 112:481-490.
15. Hajnoczky G and Hoek JB. Cell signaling. Mitochondrial longevity pathways. Science 2007, 315:607-609.
16. Salvi M, Brunati AM and Toninello A. Tyrosine phosphorylation in mitochondria: a new frontier in mitochondrial signaling. Free Radic Biol Med 2005, 38:1267-1277.
17. Satrustegui J, Pardo B and Del Arco A. Mitochondrial transporters as novel targets for intracellular calcium signaling. Physiol Rev 2007, 87:29-67.
18. Fan QW and Weiss WA. RNA interference against a glioma-derived allele of EGFR induces blockade at G2M. Oncogene 2005, 24:829-837.
19. Friedmann BJ, Caplin M, Savic B, Shah T, Lord CJ, Ashworth A and Hartley JA, et al. Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment. Mol Cancer Ther 2006, 5:209-218.
20. Penne K, Bohlin C, Schneider S and Allen D. Gefitinib (Iressa, ZD1839) and tyrosine kinase inhibitors: the wave of the future in cancer therapy. Cancer Nurs 2005, 28:481-486.
21. -/- renal cancer. Cancer Res 2005, 65:5221-5230.
22. Carter RE and Sorkin A. Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimera. J Biol Chem 1998, 273:35000-35007.
23. Jiang X, Huang F, Marusyk A and Sorkin A. Grb2 regulates internalization of EGF receptors through clathrin-coated pits. Mol Biol Cell 2003, 14:858-870.
24. Desai BN, Myers BR and Schreiber SL. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci USA 2002, 99:4319-4324.
25. Jiang X and Sorkin A. Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells. Mol Biol Cell 2002, 13:1522-1535.
26. Koster AJ and Klumperman J. Electron microscopy in cell biology: integrating structure and function. Nat Rev Mol Cell Biol 2003, Suppl: SS6-SS10.
27. Stirling JW. Immuno-and affinity probes for electron microscopy: a review of labeling and preparation techniques. J Histochem Cytochem 1990, 38:145-157.
28. Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C and Pelliccia G, et al. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 2005, 122:221-233.
29. Ventura A, Maccarana M, Raker VA and Pelicci PG. A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria. J Biol Chem 2004, 279:2299-2306.
30. Tikhomirov O and Carpenter G. Bax activation and translocation to mitochondria mediate EGF-induced programmed cell death. J Cell Sci 2005, 118:5681-5690.