Expression of FOXP3 in esophageal squamous cell carcinoma relating to the clinical data

Diseases of the Esophagus

Volumn 23, Issue 4, 2010, Pages 340-346

  Xue, L ^a   Lu, H Q ^a   He, J ^b   Zhao, X W ^a   Zhong, L ^a   Zhang, Z Z ^c   Xu, Z F ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c NAVAL MEDICAL RESEARCH INSTITUTE   (China)

Author keywords

Esophageal squamous cell carcinoma; Forkhead box protein 3; Immunohistochemistry; Reverse transcriptase polymerase chain reaction

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ADULT; ADVANCED CANCER; AGE; AGED; ARTICLE; CANCER INVASION; CANCER SIZE; CELL DIFFERENTIATION; CONTROLLED STUDY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENDER; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; BIOSYNTHESIS; CHEMISTRY; ESOPHAGUS TUMOR; METABOLISM; MIDDLE AGED; SQUAMOUS CELL CARCINOMA;

AGED; CARCINOMA, SQUAMOUS CELL; ESOPHAGEAL NEOPLASMS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MALE; MIDDLE AGED;

EID: 78049446299     PISSN: 11208694     EISSN: 14422050     Source Type: Journal    
DOI: 10.1111/j.1442-2050.2009.01013.x     Document Type: Article

References (33)

1. Brunkow ME, Jefery EW, Hjerrild K A, Paeper B, Clark L B, Yasayko S A. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001; 27: 68-73.
2. Kaestner K H, Knoc H W, Martinez D E. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev 2000; 14: 1112-46.
3. Cofer P J, Burgering B M. Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol 2004; 4:889-99.
4. Gallimore A, Godkin A. Regulatory T cells and tumour immunity observations in mice and men. Immunology 2008; 123:157-63.
5. Bignone P A, Banham A H. FOXP3+ regulatory T cells as biomarkers in human malignancies. Expert Opin Biol Ther 2008; 8: 1897-920.
6. Hori S, Nomra T, Sakaguchi S. Control of regulatory T cell development by the transcription factor FOXP3. Science 2003; 299: 1057-61.
7. + regulatory T cells. Nat Immunol 2003; 4: 3102-336.
8. + cell effect or function. J Immunol 2003; 11: 1216-23.
9. + T regulatory cells. Nat lmmunol 2003; 4: 337-42.
10. Schubert L A, Jefery E, Zhang Y, Ramsdell F, Ziegler S F. Scurfin (FOXP3) acts as a repressor of transcription an d regulates T cell activation. J Biol Chem 2001; 276: 37672-9.
11. Koji K, Hiromichi K, Akihiro T et al. CD4(+)CD25 high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers. Cancer Immunol Immunother 2006; 55: 1064-71.
12. Wilczynski J R, Radwan M, Kalinka J. The characterization and role of regulatory T cells in immune reactions. Front Biosci 2008; 1 (13): 2266-74.
13. Anna M. Wolf role of forkhead box protein 3 expression in invasive breast cancer. J Clin Onclol 2007; 25: 4499-511.
14. + regulatory T cells. Cancer Res 2008; 68: 292-1020.
15. + T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma. Hum Immunol 2006; 67 (5):1-12.
16. Hinz S, Pagerols-Raluy L, Oberg H H, Ammerpohl O, Grüssel S, Sipos B. FOXP3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res 2007; 67: 8344-50.
17. Kiniwa Y, Miyahara Y, Wang H Y, Peng W, Peng G, Wheeler T M. CD8+ FOXP3+ regulatory T cells mediate immunosuppression in prostate cancer. Clin Cancer Res 2007; 13: 6947-58.
18. Miracco C, Mourmouras V, Biagioli M, Rubegni P, Mannucci S, Monciatti I. Utility of tumour-infiltrating CD25+ FOXP3+ regulatory T cell evaluation in predicting local recurrence in vertical growth phase cutaneous melanoma. Oncol Rep 2007; 18: 1115-22.
19. Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of FOXP3(+) regulatory T cells in gastric cancer. Int J Cancer 2008; 122:2286-2293.
20. Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H. Localisation pattern of FOXP3(+) regulatory T cells is associated with clinical behaviour in gastric cancer. Br J Cancer 2008; 98: 148-53.
21. + regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. Haematologica 2008; 93:193-200.
22. Wolf D, Wolf AM, Rumpold H, Fiegl H, Zeimet A G, Muller- Holzner E. The expression of the regulatory T cell-specific forkhead box transcription factor FOXP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res 2005; 11:8326-31.
23. (+) T cells in tumors from patients with early-stage non-small cell lung cancer and latestage ovarian cancer. Cancer Res 2001; 61: 4766-72.
24. Zuo T, Liu R, Zhang H, Chang X, Liu Y, Wang L. FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J Clin Invest 2007; 117: 3765-73.
25. Carlsson P, Mahlapuu M. Forkhead transcription factors: key players in development and metabolism. Dev Biol 2002; 250 (1): 1-23.
26. + regulatory T cells. Nat Immunol 2003; 4: 3102-336.
27. + T cells by hunmn mature autologous dendritic cels. Eur J Immunol 2004; 34: 762-72.
28. Yoshioka T, MiyamotoM, Cho Y, Ishikawa K, Tsuchikawa T, Kadoya M. Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell carcinoma. Br J Cancer 2008; 98: 1258-63.
29. + regulatory T cells: from basic research to potential therapeutic use. Swiss Med Wkly 2007; 137: 625-34.
30. + regulatory T cells. Nat Med 2005; 11: 1233-43.
31. + cells to suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol 2004; 172: 5213-21.
32. Zou W. Immunosuppressive networks in the tumour environmentand their therapeutic relevance. Nat Rev Cancer 2005; 5:263-74.
33. Fantini M C, Becker C, Monteleone G, Pallone F, Galle P R, Neurath M F. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25-T cells through FOXP3 induction and down-regulation of Smad7. J Inmmnol 2004; 172: 5149-53.