Sulforaphane modulates the expression of Cyp6a2 and Cyp6g1 in larvae of the ST and HB crosses of the Drosophila wing spot test and is genotoxic in the ST cross

Food and Chemical Toxicology

Volumn 48, Issue 12, 2010, Pages 3333-3339

  Vazquez Gomez G ^a   Sanchez Santos A ^a   Vazquez Medrano J ^a   Quintanar Zuniga R ^a   Monsalvo Reyes, A C ^a   Piedra Ibarra, E ^a   Duenas Garcia I E ^a   Castaneda Partida L ^a   Graf, U ^b   Heres Pulido, M E ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b ETH ZURICH   (Switzerland)

Author keywords

Broccoli; CYP450s; Dimethyl sulfoxide; Drosophila; NADH; SMART

Indexed keywords

BETA ACTIN; CYTOCHROME P450; CYTOCHROME P450 CYP6A2; CYTOCHROME P450 CYP6G1; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SULFORAPHANE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHROPOD LARVA; ARTICLE; CONTROLLED STUDY; CROSS BREEDING; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENOTOXICITY; MALE; MUTAGENIC ACTIVITY; NONHUMAN; SOMATIC CROSSING OVER;

ACTINS; ANIMALS; ANTICARCINOGENIC AGENTS; CROSSES, GENETIC; CYTOCHROME P-450 ENZYME SYSTEM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENETIC VECTORS; HYPNOTICS AND SEDATIVES; LARVA; MUTAGENICITY TESTS; MUTAGENS; NAD; OLIGONUCLEOTIDES; PHENOBARBITAL; RECOMBINATION, GENETIC; THIOCYANATES; WING;

BRASSICA OLERACEA VAR. ITALICA; DROSOPHILA MELANOGASTER;

EID: 78049438058     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.08.038     Document Type: Article

References (49)

1. Anwar-Mohamed A., El-Kadi A.O. Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells. Cancer Lett. 2009, 275:93-101.
2. Bergé J.B., Feyereisen R., Amichot M. Cytochrome P450 monooxygenases and insecticide resistance in insects. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 1998, 353:1701-1705.
3. Bhaskara S., Dean E.D., Lam V., Ganguly R. Induction of two cytochrome P450 genes, Cyp6a2 and Cyp6a8, of Drosophila melanogaster by caffeine in adult flies and in cell culture. Gene 2006, 377:56-64.
4. Bradford M.M. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal. Biochem. 1976, 72:248-254.
5. Brooks J.D., Paton V.G., Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol. Biomarkers Prev. 2001, 10:949-954.
6. Brun A., Cuany A., Le Mouel T., Berge J., Amichot M. Inducibility of the Drosophila melanogaster cytochrome P450 gene, CYP6A2, by phenobarbital in insecticide susceptible or resistant strains. Insect. Biochem. Mol. Biol. 1996, 26:697-703.
7. Castañeda-Partida, L., Heres-Pulido, M.E., Guzmán-Rincón, J., Hernández-Portilla, LB., Dueñas-García, I.E., Durán-Díaz, A., Delfín-Alcalá, I. 2010. Lead acetate does not inhibit dimethylnitrosamine activation and interacts with phenobarbital which is genotoxic in the Drosophila wing spot test. (Waiting final decision).
8. Chung H., Bogwitz M.R., McCart C., Andrianopoulos A., Ffrench-Constant R.H., Batterham P., Daborn P.J. Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Drosophila melanogaster insecticide resistance gene Cyp6g1. Genetics 2006, 175:1071-1077.
9. Daborn P., Boundy S., Yen J., Pittendrigh B., ffrench-Constant R. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Mol. Genet. Genomics. 2001, 266:556-563.
10. Daborn P.J., Lumb C., Boey A., Wong W., Ffrench-Constant R.H., Batterham P. Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression. Insect. Biochem. Mol. Biol. 2007, 37:512-519.
11. Daborn P.J., Yen J.L., Bogwitz M.R., Le Goff G., Feil E., Jeffers S., Tijet N., Perry T., Heckel D., Batterham P., Feyereisen R., Wilson T.G., ffrench-Constant R.H. A single P450 allele associated with insecticide resistance in Drosophila. Science 2002, 297:2253-2256.
12. Dueñas I.E., Heres M.E., Castañeda P.L., Graf U. Easy rising of Drosophila melanogaster consisting of mashed potato flakes and a preservative solution. Technique note. Drosoph. Inf. Serv. 2002, 84:166.
13. Dunkov B.C., Guzov V.M., Mocelin G., Shotkoski F., Brun A., Amichot M., Ffrench-Constant R.H., Feyereisen R. The Drosophila cytochrome P450 gene Cyp6a2: structure, localization, heterologous expression, and induction by phenobarbital. DNA Cell. Biol. 1997, 16:1345-1356.
14. Dunkov B.C., Rodriguez-Arnaiz R., Pittendrigh B., ffrench-Constant R.H., Feyereisen R. Cytochrome P450 gene clusters in Drosophila melanogaster. Mol. Gen. Genet. 1996, 251:290-297.
15. Easterbrook J., Lu C., Sakai Y., Li A.P. Effects of organic solvents on the activities of Cytochrome P450 Isoforms, udp-dependent glucuronyl transferase, and phenol Sulfotransferase in human hepatocytes. Drug. Metab. Dispos. 2001, 29:141-144.
16. Frei H., Würgler F.E. Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative or inconclusive result. Mutat. Res. 1988, 203:297-308.
17. Frei H., Clements J., Howe D., Wurgler F.E. The genotoxicity of the anticancer drug mitoxantrone in somatic and germ cells of Drosophila melanogaster. Mutat. Res. 1992, 279:21-33.
18. Frei H., Würgler F.E. Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila. Mutat. Res. 1995, 334:247-258.
19. Frölich A., Würgler F.E. New tester strains with improved bioactivation capacity for the Drosophila wing spot test. Mutat. Res. 1989, 216:179-187.
20. Fuchs S.S.Y., Spiegelman V.S., Belitsky G.A. The effect of the cytochrome P450 system inducers on the development of Drosophila melanogaster. J. Biochem. Toxicol. 1993, 8:83-88.
21. Graf U. Analysis of the relationship between age of larvae at mutagen treatment and frequency and size of spots in the wing somatic mutation and recombination test in Drosophila melanogaster. Experientia. 1995, 51:168-173.
22. Graf U., Singer D. Genotoxicity testing of promutagens in the wing somatic mutation and recombination test in Drosophila melanogaster. Rev. Int. Contam. Ambient. 1992, 8:15-27.
23. Graf U., van Schaik N. Improved high bioactivation cross for the wing somatic mutation and recombination test (SMART) in Drosophila melanogaster. Mutat. Res. 1992, 271:59-67.
24. Graf U., Würgler F.E., Katz A.J., Frei H., Juon H., Hall C.B., Kale P.G. Somatic mutation and recombination test in Drosophila melanogaster. Environ. Mutagen. 1984, 6:153-188.
25. Graf U., Frei H., Kagi A., Katz A.J., Wurgler F.E. Thirty compounds tested in the Drosophila wing spot test. Mutat. Res. 1989, 222:359-373.
26. Guzman-Rincón J., Graf U. Drosophila melanogaster somatic mutation and recombination test as a biomonitor. Biomonitors and biomarkers as indicators of Environmental Change: A handbook 1995, 169-181. Plenum Press Publishes, New York, NY. F.M. Butterworth, L.D. Corkum, J. Guzman-Rincon (Eds.).
27. Jiang Z.Q., Chen C., Yang B., Hebbar V., Kong A.N. Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers. Life Sci. 2003, 72:2243-2253.
28. Juge N., Mithen R.F., Traka M. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell. Mol. Life Sci. 2007, 64:1105-1127.
29. Kanebratt K.P., Andersson T.B. Evaluation of HepaRG Cells as an in vitro model for human drug metabolism studies. Drug. Metab. Dispos. 2008, 36:1444-1452.
30. Le Goff G., Hilliou F., Siegfried B.D., Boundy S., Wajnberg E., Sofer L., Audant P., ffrench-Constant R.H., Feyereisen R. Xenobiotic response in Drosophila melanogaster sex dependence of P450 and GST gene induction. Insect. Biochem. Mol. Biol. 2006, 36:674-682.
31. Logemann J., Schell J., Willmitzer L. Improved method for the isolation of RNA from plant tissues. Anal. Biochem. 1987, 15:16-20.
32. Mahéo K., Morel F., Langouët S., Kramer H., Le Ferrec E., Ketterer B., Guillouzo A. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997, 57:3649-3652.
33. McCart C., Ffrench-Constant R.H. Dissecting the insecticide-resistance associated cytochrome P450 gene Cyp6g1. Pest. Manag. Sci. 2008, 64:639-645.
34. Nishimura M., Ueda N., Naito S. Effects of dimethyl sulfoxide on the gene induction of cytochrome P450 isoforms, UGT-dependent glucuronosyl transferase isoforms, and ABCB1 in primary culture of human hepatocytes. Biol Pharm Bull. 2003, 26:1052-1056.
35. Plant, N., 2003. Molecular Toxicology, edited by Bios Scientific Publishers Taylor & Francis Group, Series: Advanced Texts, London and New York.
36. Prochaska H.J., Santamaria A.B., Talalay P. Rapid detection of inducers of enzymes that protect against carcinogens. Proc. Natl. Acad. Sci. USA 1992, 89:2394-2398.
37. Pyke F.M., Bogwitz M.R., Perry T., Monk A., Batterham P., McKenzie J.A. The genetic basis of resistance to diazinon in natural populations of Drosophila melanogaster. Genetica 2004, 121:13-24.
38. Santos N.C., Figueira-Coelho J., Martins-Silva J., Saldanha C. Multidisciplinary utilization of dimethyl sulfoxide:pharmacological, cellular, and molecular aspects. Biochem. Pharmacol. 2003, 65:1035-1104.
39. Sokolovic M., Garaj-Vrhovac V., Ramic S., Simpraga B. Chicken nucleated blood cells as a cellular model for genotoxicity testing using the comet assay. Food Chem. Toxicol. 2007, 45:2165-2170.
40. Spitz M.R., Duphorne C.M., Detry M.A., Pillow P.C., Amos C.I., Lei L., de Andrade M., Gu X., Hong W.K., Wu X. Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiol. Biomarkers Prev. 2000, 9:1017-1020.
41. Sun W., Margam V.M., Sun L., Buczkowski G., Bennett G.W., Schemerhorn B., Muir W.M., Pittendrigh B.R. Genome-wide analysis of phenobarbital-inducible genes in Drosophila melanogaster. Insect Mol. Biol. 2006, 15:455-464.
42. Talalay P., Fahey J., Holtzclaw W., Prestera T., Zhang Y. Chemoprotection against cancer by induction of phase 2 enzymes. Toxicol. Lett. 1995, 82-83:173-179.
43. Tan X.L., Spivack S.D. Dietary chemoprevention strategies for induction of phase II xenobioticmetabolizing enzymes in lung carcinogenesis: a review. Lung Cancer 2009, 65:129-137.
44. Wang L.I., Giovannucci E.L., Hunter D., Neuberg D., Su L., Christiani D.C. Dietary intake of cruciferous vegetables, glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population. Cancer Causes Control 2004, 15:977-985.
45. Yang J., McCart C., Woods D.J., Terhzaz S., Greenwood K.G., ffrench-Constant R.H., Dow J.A. A Drosophila systems approach to xenobiotic metabolism. Physiol. Genomics 2007, 30:223-231.
46. Zangar R.C., Novak R.F. Posttranslational elevation of cytochrome P450 3A levels and activity by dimethyl sulfoxide. Arch. Biochem. Biophys. 1998, 353:1-9.
47. Zhang Y., Talalay P. Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer Res. 1994, 54:976-1981.
48. Zhang Y., Talalay P., Cho C.G., Posner G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA 1992, 89:2399-2403.
49. Zhang Y., Kensler T.W., Cho C.G., Posner G.H., Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates Proc. Natl. Acad. Sci. USA 1994, 91:3147-3150.