Internalizing cancer antibodies from phage libraries selected on tumor cells and yeast-displayed tumor antigens

Journal of Molecular Biology

Volumn 404, Issue 1, 2010, Pages 88-99

  Zhou, Yu ^a   Zou, Hao ^a   Zhang, Shaoyi ^a   Marks, James D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Basaloid breast cancer; Phage display; Single chain Fv antibody; Yeast display

Indexed keywords

CANCER ANTIBODY; HERMES ANTIGEN; MEMBRANE ANTIGEN; PROTEIN EPHA2; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY LIBRARY; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BACTERIOPHAGE; CANCER CELL CULTURE; CELL SURFACE; CELL TYPE; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; TUMOR CELL;

MAMMALIA;

EID: 78049433698     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.09.006     Document Type: Article

References (52)

1. Baselga J., Tripathy D., Mendelsohn J., Baughman S., Benz C.C., Dantis L., et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J. Clin. Oncol. 1996, 14:737-744.
2. Hainsworth J.D., Burris H.A., Morrissey L.H., Litchy S., Scullin D.C., Bearden J.D., et al. Rituximab monoclonal antibody as initial systemic therapy for patients with low-grade non-Hodgkin lymphoma. Blood 2000, 95:3052-3056.
3. Cunningham D., Humblet Y., Siena S., Khayat D., Bleiberg H., Santoro A., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 2004, 351:337-345.
4. Perou C.M., Sorlie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Rees C.A., et al. Molecular portraits of human breast tumours. Nature 2000, 406:747-752.
5. Sorlie T., Perou C.M., Tibshirani R., Aas T., Geisler S., Johnsen H., et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad. Sci. USA 2001, 98:10869-10874.
6. Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006, 10:515-527.
7. Cai X., Garen A. Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: selection of specific antibodies from single-chain Fv fusion phage libraries. Proc. Natl Acad. Sci. USA 1995, 92:6537-6541.
8. de Kruif J., Terstappen L., Boel E., Logtenberg T. Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library. Proc. Natl Acad. Sci. USA 1995, 92:3938-3942.
9. Poul M.A., Becerril B., Nielsen U.B., Morisson P., Marks J.D. Selection of tumor-specific internalizing human antibodies from phage libraries. J. Mol. Biol. 2000, 301:1149-1161.
10. Heitner T., Moor A., Garrison J.L., Marks C., Hasan T., Marks J.D. Selection of cell binding and internalizing epidermal growth factor receptor antibodies from a phage display library. J. Immunol. Methods 2001, 248:17-30.
11. Gao C., Mao S., Ronca F., Zhuang S., Quaranta V., Wirsching P., Janda K.D. De novo identification of tumor-specific internalizing human antibody-receptor pairs by phage-display methods. J. Immunol. Methods 2003, 274:185-197.
12. Liu B., Conrad F., Cooperberg M.R., Kirpotin D.B., Marks J.D. Mapping tumor epitope space by direct selection of single-chain Fv antibody libraries on prostate cancer cells. Cancer Res. 2004, 64:704-710.
13. Goenaga A.L., Zhou Y., Legay C., Bougherara H., Huang L., Liu B., et al. Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Mol. Immunol. 2007, 44:3777-3788.
14. Sapra P., Allen T.M. Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs. Cancer Res. 2002, 62:7190-7194.
15. Nielsen U.B., Kirpotin D.B., Pickering E.M., Hong K., Park J.W., Refaat Shalaby M., et al. Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis. Biochim. Biophys. Acta 2002, 1591:109-118.
16. Pastan I., Hassan R., Fitzgerald D.J., Kreitman R.J. Immunotoxin therapy of cancer. Nat. Rev. Cancer 2006, 6:559-565.
17. Lewis Phillips G.D., Li G., Dugger D.L., Crocker L.M., Parsons K.L., Mai E., et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res. 2008, 68:9280-9290.
18. Liu B., Conrad F., Roth A., Drummond D.C., Simko J.P., Marks J.D. Recombinant full-length human IgG1 s targeting hormone-refractory prostate cancer. J. Mol. Med. 2007, 85:1113-1123.
19. Matsumura Y., Tarin D. Significance of CD44 gene products for cancer diagnosis and disease evaluation. Lancet 1992, 340:1053-1058.
20. Marhaba R., Zoller M. CD44 in cancer progression: adhesion, migration and growth regulation. J. Mol. Histol. 2004, 35:211-231.
21. Hamilton S.R., Fard S.F., Paiwand F.F., Tolg C., Veiseh M., Wang C., et al. The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J. Biol. Chem. 2007, 282:16667-16680.
22. Andres A.C., Reid H.H., Zurcher G., Blaschke R.J., Albrecht D., Ziemiecki A. Expression of two novel Eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. Oncogene 1994, 9:1461-1467.
23. Zelinski D.P., Zantek N.D., Stewart J.C., Irizarry A.R., Kinch M.S. EphA2 overexpression causes tumorigenesis of mammary epithelial cells. Cancer Res. 2001, 61:2301-2306.
24. Macrae M., Neve R.M., Rodriguez-Viciana P., Haqq C., Yeh J., Chen C., et al. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell 2005, 8:111-118.
25. Razai A., Garcia-Rodriguez C., Lou J., Geren I.N., Forsyth C.M., Robles Y., et al. Molecular evolution of antibody affinity for sensitive detection of botulinum neurotoxin type A. J. Mol. Biol. 2005, 351:158-169.
26. O'Connell D., Becerril B., Roy-Burman A., Daws M., Marks J.D. Phage versus phagemid libraries for generation of human monoclonal antibodies. J. Mol. Biol. 2002, 321:49-56.
27. Becerril B., Poul M.A., Marks J.D. Toward selection of internalizing antibodies from phage libraries. Biochem. Biophys. Res. Commun. 1999, 255:386-393.
28. An F., Drummond D.C., Wilson S., Kirpotin D.B., Nishimura S.L., Broaddus V.C., Liu B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies. Mol. Cancer Ther. 2008, 7:569-578.
29. Bidlingmaier S., He J., Wang Y., An F., Feng J., Barbone D., et al. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 2009, 69:1570-1577.
30. Park J.W., Hong K., Carter P., Asgari H., Guo L.Y., Keller G.A., et al. Development of anti-p185HER2 immunoliposomes for cancer therapy. Proc. Natl Acad. Sci. USA 1995, 92:1327-1331.
31. Beers R., Chowdhury P., Bigner D., Pastan I. Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display. Clin. Cancer Res. 2000, 6:2835-2843.
32. Mamot C., Drummond D.C., Greiser U., Hong K., Kirpotin D.B., Marks J.D., Park J.W. Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells. Cancer Res. 2003, 63:3154-3161.
33. Eliaz R.E., Nir S., Szoka F.C. Interactions of hyaluronan-targeted liposomes with cultured cells: modeling of binding and endocytosis. Methods Enzymol. 2004, 387:16-33.
34. Hayes M.E., Drummond D.C., Hong K., Park J.W., Marks J.D., Kirpotin D.B. Assembly of nucleic acid-lipid nanoparticles from aqueous-organic monophases. Biochim. Biophys. Acta 2006, 1758:429-442.
35. Zhou Y., Drummond D.C., Zou H., Hayes M.E., Adams G.P., Kirpotin D.B., Marks J.D. Impact of single-chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor-expressing tumor cells. J. Mol. Biol. 2007, 371:934-947.
36. Roth A., Drummond D.C., Conrad F., Hayes M.E., Kirpotin D.B., Benz C.C., et al. Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells. Mol. Cancer Ther. 2007, 6:2737-2746.
37. Bradbury A., Persic L., Werge T., Cattaneo A. Use of living columns to select specific phage antibodies. Biotechnology (NY) 1993, 11:1565-1569.
38. Boder E.T., Wittrup K.D. Yeast surface display for screening combinatorial polypeptide libraries. Nat. Biotechnol. 1997, 15:553-557.
39. Cochran J.R., Kim Y.S., Olsen M.J., Bhandari R., Wittrup K.D. Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments. J. Immunol. Methods 2004, 287:147-158.
40. Piatesi A., Howland S.W., Rakestraw J.A., Renner C., Robson N., Cebon J., et al. Directed evolution for improved secretion of cancer-testis antigen NY-ESO-1 from yeast. Protein Expression Purif. 2006, 48:232-242.
41. Wadle A., Mischo A., Imig J., Wullner B., Hensel D., Watzig K., et al. Serological identification of breast cancer-related antigens from a Saccharomyces cerevisiae surface display library. Int. J. Cancer 2005, 117:104-113.
42. Bowley D.R., Jones T.M., Burton D.R., Lerner R.A. Libraries against libraries for combinatorial selection of replicating antigen-antibody pairs. Proc. Natl Acad. Sci. USA 2009, 106:1380-1385.
43. Bidlingmaier S., Liu B. Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions. Mol. Cell Proteomics 2006, 5:533-540.
44. Feldhaus M.J., Siegel R.W., Opresko L.K., Coleman J.R., Feldhaus J.M., Yeung Y.A., et al. Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library. Nat. Biotechnol. 2003, 21:163-170.
45. Gietz R.D., Schiestl R.H. Applications of high efficiency lithium acetate transformation of intact yeast cells using single-stranded nucleic acids as carrier. Yeast 1991, 7:253-263.
46. Orr-Weaver T.L., Szostak J.W. Yeast recombination: the association between double-strand gap repair and crossing-over. Proc. Natl Acad. Sci. USA 1983, 80:4417-4421.
47. Sheets M.D., Amersdorfer P., Finnern R., Sargent P., Lindquist E., Schier R., et al. Efficient construction of a large nonimmune phage antibody library: the production of high-affinity human single-chain antibodies to protein antigens. Proc. Natl Acad. Sci. USA 1998, 95:6157-6162.
48. Huie M.A., Cheung M.C., Muench M.O., Becerril B., Kan Y.W., Marks J.D. Antibodies to human fetal erythroid cells from a nonimmune phage antibody library. Proc. Natl Acad. Sci. USA 2001, 98:2682-2687.
49. Marks J.D., Hoogenboom H.R., Bonnert T.P., McCafferty J., Griffiths A.D., Winter G. By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 1991, 222:581-597.
50. Schier R., Marks J.D., Wolf E.J., Apell G., Wong C., McCartney J.E., et al. In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library. Immunotechnology 1995, 1:73-81.
51. Hochuli E. Large-scale chromatography of recombinant proteins. J. Chromatogr. 1988, 444:293-302.
52. Schier R., Bye J., Apell G., McCall A., Adams G.P., Malmqvist M., et al. Isolation of high-affinity monomeric human anti-c-erbB-2 single chain Fv using affinity-driven selection. J. Mol. Biol. 1996, 255:28-43.