Osteopontin is required for unloading-induced osteoclast recruitment and modulation of RANKL expression during tooth drift-associated bone remodeling, but not for super-eruption

Bone

Volumn 47, Issue 6, 2010, Pages 1020-1029

  Walker, Cameron G ^a   Dangaria, Smit ^a   Ito, Yoshihiro ^a   Luan, Xianghong ^a   Diekwisch, Thomas G H ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Bone remodeling; ERK; Mechanical stress; Osteopontin; PI3K; RANKL

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT OSTEOPONTIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ALVEOLAR BONE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE REMODELING; CANCER CELL CULTURE; CELL COUNT; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; IN VITRO STUDY; MALE; MOLAR TOOTH; MOUSE; NONHUMAN; OSTEOCLAST; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TOOTH ERUPTION;

ANIMALS; BONE MARROW CELLS; BONE REMODELING; CELL COUNT; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLAR; OSTEOCLASTS; OSTEOPONTIN; OSTEOPROTEGERIN; PERIODONTAL LIGAMENT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RANK LIGAND; TOOTH ERUPTION; TOOTH MIGRATION; WEIGHT-BEARING;

EID: 78049430877     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.08.025     Document Type: Article

References (46)

1. Wolff J. Über die innere Architectur der Knochen und ihre Bedeutung für die Frage vom Knochenwachstum. Virchows Arch Pathol Anat Physiol Klin Med 1870, 50:389-463.
2. Raisz L.G. Physiology and pathophysiology of bone remodeling. Clin Chem 1999, 45:1353-1358.
3. Frost H.M. Bone's mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol 2003, 275:1081-1101.
4. Storey E., Feik S.A. Remodelling of bone and bones: effects of altered mechanical stress on caudal vertebrae. J Anat 1985, 140(Pt 1):37-48.
5. Terai K., Takano-Yamamoto T., Ohba Y., Hiura K., Sugimoto M., Sato M., et al. Role of osteopontin in bone remodeling caused by mechanical stress. J Bone Miner Res 1999, 14:839-849.
6. Nomura S., Takano-Yamamoto T. Molecular events caused by mechanical stress in bone. Matrix Biol 2000, 19:91-96.
7. Ishijima M., Tsuji K., Rittling S.R., Yamashita T., Kurosawa H., Denhardt D.T., et al. Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice. J Bone Miner Res 2002, 17:661-667.
8. Ishijima M., Tsuji K., Rittling S.R., Yamashita T., Kurosawa H., Denhardt D.T., et al. Osteopontin is required for mechanical stress-dependent signals to bone marrow cells. J Endocrinol 2007, 193:235-243.
9. Sodek J., Ganss B., McKee M.D. Osteopontin. Crit Rev Oral Biol Med 2000, 11:279-303.
10. Kazanecki C.C., Uzwiak D.J., Denhardt D.T. Control of osteopontin signaling and function by post-translational phosphorylation and protein folding. J Cell Biochem 2007, 102:912-924.
11. Zhu B., Suzuki K., Goldberg H.A., Rittling S.R., Denhardt D.T., McCulloch C.A., et al. Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontin. J Cell Physiol 2004, 198:155-167.
12. Zohar R., Suzuki N., Suzuki K., Arora P., Glogauer M., McCulloch C.A., et al. Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration. J Cell Physiol 2000, 184:118-130.
13. Fujihara S., Yokozeki M., Oba Y., Higashibata Y., Nomura S., Moriyama K. Function and regulation of osteopontin in response to mechanical stress. J Bone Miner Res 2006, 21:956-964.
14. Ishijima M., Rittling S.R., Yamashita T., Tsuji K., Kurosawa H., Nifuji A., et al. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. J Exp Med 2001, 193:399-404.
15. Weber G.F., Ashkar S., Glimcher M.J., Cantor H. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science 1996, 271:509-512.
16. Chellaiah M.A., Hruska K.A. The integrin alpha(v)beta(3) and CD44 regulate the actions of osteopontin on osteoclast motility. Calcif Tissue Int 2003, 72:197-205.
17. Suzuki K., Zhu B., Rittling S.R., Denhardt D.T., Goldberg H.A., McCulloch C.A., et al. Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. J Bone Miner Res 2002, 17:1486-1497.
18. Gross T.S., King K.A., Rabaia N.A., Pathare P., Srinivasan S. Upregulation of osteopontin by osteocytes deprived of mechanical loading or oxygen. J Bone Miner Res 2005, 20:250-256.
19. Kuroda S., Balam T.A., Sakai Y., Tamamura N., Takano-Yamamoto T. Expression of osteopontin mRNA in odontoclasts revealed by in situ hybridization during experimental tooth movement in mice. J Bone Miner Metab 2005, 23:110-113.
20. Wongkhantee S., Yongchaitrakul T., Pavasant P. Mechanical stress induces osteopontin expression in human periodontal ligament cells through rho kinase. J Periodontol 2007, 78:1113-1119.
21. Wongkhantee S., Yongchaitrakul T., Pavasant P. Mechanical stress induces osteopontin via ATP/P2Y1 in periodontal cells. J Dent Res 2008, 87:564-568.
22. Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
23. Teitelbaum S.L. Bone resorption by osteoclasts. Science 2000, 289:1504-1508.
24. Boyce B.F., Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 2008, 473:139-146.
25. Wu X., Pan G., McKenna M.A., Zayzafoon M., Xiong W.C., McDonald J.M. RANKL regulates Fas expression and Fas-mediated apoptosis in osteoclasts. J Bone Miner Res 2005, 20:107-116.
26. Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998, 93:165-176.
27. Burgess T.L., Qian Y., Kaufman S., Ring B.D., Van G., Capparelli C., et al. The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol 1999, 145:527-538.
28. Kanzaki H., Chiba M., Shimizu Y., Mitani H. Dual regulation of osteoclast differentiation by periodontal ligament cells through RANKL stimulation and OPG inhibition. J Dent Res 2001, 80:887-891.
29. Kanzaki H., Chiba M., Takahashi I., Haruyama N., Nishimura M., Mitani H. Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement. J Dent Res 2004, 83:920-925.
30. Holliday S., Schneider B., Galang M.T., Fukui T., Yamane A., Luan X., et al. Bones, teeth, and genes: a genomic homage to Harry Sicher's "Axial Movement of Teeth". World J Orthod 2005, 6:61-70.
31. Luan X., Ito Y., Holliday S., Walker C., Daniel J., Galang T.M., et al. Extracellular matrix-mediated tissue remodeling following axial movement of teeth. J Histochem Cytochem 2007, 55:127-140.
32. Luan X., Diekwisch T.G. Vienna-Chicago: the cultural transformation of the model system of the un-opposed molar. Bioessays 2007, 29:819-830.
33. Walker C.G., Ito Y., Dangaria S., Luan X., Diekwisch T.G. RANKL, osteopontin, and osteoclast homeostasis in a hyperocclusion mouse model. Eur J Oral Sci 2008, 116:312-318.
34. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
35. Ishii T., Ohshima S., Ishida T., Mima T., Tabunoki Y., Kobayashi H., et al. Osteopontin as a positive regulator in the osteoclastogenesis of arthritis. Biochem Biophys Res Commun 2004, 316:809-815.
36. Mori K., Blanchard F., Charrier C., Battaglia S., Ando K., Duplomb L., et al. Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk. Cancer Sci 2008, 99:2170-2176.
37. Oshiro T., Shiotani A., Shibasaki Y., Sasaki T. Osteoclast induction in periodontal tissue during experimental movement of incisors in osteoprotegerin-deficient mice. Anat Rec 2002, 266:218-225.
38. Schneider B.J., Meyer J. Experimental studies on the interrelations of condylar growth and alveolar bone formation. Angle Orthod 1965, 35:187-199.
39. Yao Z., Xing L., Qin C., Schwarz E.M., Boyce B.F. Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism. J Biol Chem 2008, 283:9917-9924.
40. Takahashi H., Epker B., Frost H.M. Resorption precedes formative activity. Surg Forum 1964, 15:437-438.
41. Ishijima M., Ezura Y., Tsuji K., Rittling S.R., Kurosawa H., Denhardt D.T., et al. Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss. Exp Cell Res 2006, 312:3075-3083.
42. Chung C.J., Soma K., Rittling S.R., Denhardt D.T., Hayata T., Nakashima K., et al. OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application. J Cell Physiol 2008, 214:614-620.
43. George A., Evans C. Detection of root resorption using dentin and bone markers. Orthod Craniofac Res 2009, 12:229-235.
44. Yamaguchi M., Aihara N., Kojima T., Kasai K. RANKL increase in compressed periodontal ligament cells from root resorption. J Dent Res 2006, 85:751-756.
45. Shaul Y.D., Seger R. The MEK/ERK cascade: from signaling specificity to diverse functions. BBA 2007, 1773:1213-1226.
46. Zehorai E., Yao Z., Plotnikov A., Seger R. The subcellular localization of MEK and ERK-A novel nuclear translocation signal (NTS) paves a way to the nucleus. Mol Cell Endocrinol 2010, 314:213-220.