P38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription

Stem Cells and Development

Volumn 19, Issue 11, 2010, Pages 1723-1734

  Wu, Jinzhan ^a,b   Kubota, Junko ^b   Hirayama, Jun ^a   Nagai, Yoko ^a,b   Nishina, Sachiko ^c   Yokoi, Tadashi ^a,c   Asaoka, Yoichi ^a   Seo, Jungwon ^a,b   Shimizu, Nao ^a,b   Kajiho, Hiroaki ^b   Watanabe, Takashi ^d   Azuma, Noriyuki ^c   Katada, Toshiaki ^b   Nishina, Hiroshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^d KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BONE MORPHOGENETIC PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOCYTE ENHANCER FACTOR 2; NOGGIN; STRESS ACTIVATED PROTEIN KINASE; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG INHIBITION; EMBRYONIC STEM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; MOUSE; MUSCLE DEVELOPMENT; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MICE; MYOCYTES, CARDIAC; MYOGENIC REGULATORY FACTORS; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; TRANSCRIPTION, GENETIC;

MURINAE;

EID: 78049385751     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2010.0066     Document Type: Article

References (44)

1. Evans MJ and M Kaufman. (1981). Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154-156.
2. Martin GR. (1981). Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78:7634-7638.
3. Smith AG, JK Heath, DD Donaldson, GG Wong, J Moreau, M Stahl and D Rogers. (1988). Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 336:688-690.
4. Williams RL, DJ Hilton, S Pease, TA Willson, CL Stewart, DP Gearing, EF Wagner, D Metcalf, NA Nicola and NM Gough. (1988). Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336:684-687.
5. Smith AG. (2001). Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 17:435-462.
6. Davis RJ. (2000). Signal transduction by the JNK group of MAP kinases. Cell 103:239-252.
7. Chang L and M Karin. (2001). Mammalian MAP kinase signalling cascades. Nature 410:37-40.
8. Han J, JD Lee, L Bibbs and RJ Ulevitch. (1994). A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:156-160.
9. Lee JC, JT Laydon, PC McDonnell, TF Gallagher, S Kumar, D Green, D McNulty, MJ Blumenthal, JR Keys, SW Landvatter, JE Strickler, MM Mclaughlin, IR Siemens, SM Fisher, GP Livi, JR White, JL Adama and PR Young. (1994). A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739-746.
10. Wang XS, K Diener, CL Manthey, S Wang, B Rosenzweig, J Bray, J Delaney, CN Cole, PY Chan-Hui, N Mantlo, HS Lichenstein, M Zukowski and Z Yao. (1997). Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. J Biol Chem 272:23668-23674.
11. Tamura K, T Sudo, U Senftleben, AM Dadak, R Johnson and M Karin. (2000). Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102:221-231.
12. Mudgett JS, J Ding, L Guh-Siesel, NA Chartrain, L Yang, S Gopal and MM Shen. (2000). Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci USA 97:10454-10459.
13. Beardmore VA, HJ Hinton, C Eftychi, M Apostolaki, M Armaka, J Darragh, McIlrath J, JM Carr, LJ Armit, C Clacher, L Malone, G Kollias and JS Arthur. (2005). Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol 23:10454-10464.
14. Han J, Y Jiang, Z Li, VV Kravchenko and RJ Ulevitch. (1997). Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386:296-299.
15. Martin JF, JM Miano, CM Hustad, NG Copeland, NA Jenkins and EN Olson. (1994). A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Mol Cell Biol 14:1647-1656.
16. Black BL and EN Olson. (1998). Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol 14:167-196.
17. Lin Q, J Schwarz, C Bucana and EN Olson. (1997). Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276:1404-1407.
18. Bi W, CJ Drake and JJ Schwarz. (1999). The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev Biol 211:255-267.
19. Czyz J and A Wobus. (2001). Embryonic stem cell differentiation: the role of extracellular factors. Differentiation 68:167-174.
20. Tiedemann H, M Asashima, H Grunz and W Knöchel. (2001). Pluripotent cells (stem cells) and their determination and differentiation in early vertebrate embryogenesis. Dev Growth Differ 43:469-502.
21. Wozney JM, V Rosen, AJ Celeste, LM Mitsock, MJ Whitters, RW Kriz, RM Hewick and EA Wang. (1988). Novel regulators of bone formation: molecular clones and activities. Science 242:1528-1534.
22. Attisano L and JL Wrana. (2002). Signal transduction by the TGF-beta superfamily. Science 296:1646-1647.
23. Shah NM, AK Groves and DJ Anderson. (1996). Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85:331-343.
24. Nishina H, KD Fischer, L Radvanyi, A Shahinian, R Hakem, EA Rubie, A Bernstein, TW Mak, JR Woodgett and JM Penninger. (1997). Stress-signaling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385:350-353.
25. Takayanagi H, S Kim, T Koga, H Nishina, M Isshiki, H Yoshida, A Saiura, M Isobe, T Yokochi, J Inoue, EF Wagner, TW Mak, T Kodama and T Taniguchi. (2002). Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling. Dev Cell 3:889-901.
26. Shimizu N, H Watanabe, J Kubota, J Wu, R Saito, T Yokoi, T Era, T Iwatsubo, T Watanabe, S Nishina, N Azuma, T Katada and H Nishina. (2009). Pax6-5a promotes neuronal differentiation of murine embryonic stem cells. Biol Pharm Bull 32:999-1003.
27. Saito R, T Yamasaki, Y Nagai, J Wu, H Kajiho, T Yokoi, E Noda, S Nishina, H Niwa, N Azuma, T Katada and H Nishina. (2009). CrxOS maintains self-renewal capacity of murine embryonic stem cells. Biochem Biophys Res Commun 390:1129-1135.
28. Ura S, H Nishina, Y Gotoh and Katada T. (2007). Activation of the JNK patyway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. Mol Cell Biol 27:5514-5522.
29. Androutsellis-Theotokis A, RR Leker, F Soldner, DJ Hoeppner, R Ravin, SW Poser, MA Rueger, SK Bae, R Kittappa and RD McKay. (2006). Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442:823-826.
30. Graichen R, X Xu, SR Braam, T Balakrishnan, S Norfiza, S Sieh, SY Soo, SC Tham, C Mummery, A Colman, R Zweigerdt and BP Davidson. (2008). Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation 76:357-370.
31. Binétruy B, L Heasley, F Bost, L Caron and M Aouadi. (2007). Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases. Stem Cells 25:1090-1095.
32. Ding L, XG Liang, Y Hu, DY Zhu and YJ Lou. (2008). Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro. Stem Cells Dev 17:751-760.
33. Cuenda A, J Rouse, YN Doza, R Meier, P Cohen, TF Gallagher, PR Young and JC Lee. (1995). SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364:229-233.
34. Aouadi M, F Bost, L Caron, K Laurent, Y Le Marchand Brustel and B Binétruy. (2006). p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis. Stem Cells 24:1399-1406.
35. Davidson SM and M Morange. (2000). Hsp25 and the p38 MAPK pathway are involved in differentiation of cardiomyocytes. Dev Biol 218:146-160.
36. Zetser A, E Gredinger and E Bengal. (1999). p38 mitogenactivated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor. J Biol Chem 274:5193-5200.
37. Liang Q and JD Molkentin. (2003). Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models. J Mol Cell Cardiol 35:1385-1394.
38. Takeda K and H Ichijo. (2002). Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system. Genes Cells 7:1099-1111.
39. Okamoto S, D Krainc, K Sherman and SA Lipton. (2000). Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proc Natl Acad Sci USA 97:7561-7566.
40. Ying QL, J Nichols, I Chambers and A Smith. (2003). BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115:281-292.
41. Zhao M, L New, VV Kravchenko, Y Kato, H Gram, F di Padova, EN Olson, RJ Ulevitch and J Han. (1999). Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol 19:21-30.
42. Yang SH, A Galanis and AD Sharrocks. (1999). Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol Cell Biol 19:4028-4038.
43. Wu Z, PJ Woodring, KS Bhakta, K Tamura, F Wen, JR Feramisco, M Karin, JY Wang and PL Puri. (2000). p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Mol Cell Biol 20:3951-3964.
44. Zhang H and A Bradley. (1996). Mice deficient for BMP2 are nonviable and have defects in amnion=chorion and cardiac development. Development 122:2977-2986.