Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay

Journal of Biological Chemistry

Volumn 285, Issue 45, 2010, Pages 34390-34400

  Ouimet, Tanja ^a   Orng, Sou Vinh ^a   Poras, Hervé ^a   Gagnidze, Khatuna ^b   Devi, Lakshmi A ^b   Fournié Zaluski, Marie Claude ^a   Roques, Bernard P ^a  

^a Pharmaleads   (France)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC PH; AMIDE BOND; ENDOTHELIN; ENDOTHELIN-CONVERTING ENZYMES; ENZYMATIC ASSAY; EX-VIVO; EXPRESSION PATTERNS; HIGH AFFINITY; HIGH THROUGHPUT SCREENING; IN-VITRO; MEMBRANE-BOUND; METALLO-PROTEASE; PEPTIDE SUBSTRATES; PHYSIOLOGICAL FUNCTIONS; SECRETORY PATHWAYS; SEQUENCE HOMOLOGY; SPECIFIC INHIBITORS; SPECIFIC TOOL; WILD TYPES;

AMIDES; ENZYMES; PEPTIDES;

SUBSTRATES;

CAPTOPRIL; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME 2; KELATORPHAN; PHOSPHORAMIDON; RETROTHIORPHAN; THIORPHAN; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALIBRATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; ENDOTHELINS; ENZYME ASSAYS; ENZYME INHIBITORS; FLUORESCENT DYES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; METALLOENDOPEPTIDASES; MICE; ORGAN SPECIFICITY; PEPTIDE LIBRARY; PEPTIDES; SUBSTRATE SPECIFICITY;

EID: 78049382416     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.120576     Document Type: Article

References (43)

1. Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D., and Yanagisawa, M. (1994) Cell 78, 473-485
2. Emoto, N., and Yanagisawa, M. (1995) J. Biol. Chem. 270, 15262-15268
3. Roques, B. P., Noble, F., Daugé, V., Fournié-Zaluski, M. C., and Beaumont, A. (1993) Pharmacol Rev. 45, 87-146
4. Valdenaire, O., Richards, J. G., Faull, R. L., and Schweizer, A. (1999) Brain Res. Mol. Brain Res. 64, 211-221
5. Kiryu-Seo, S., Sasaki, M., Yokohama, H., Nakagomi, S., Hirayama, T., Aoki, S., Wada, K., and Kiyama, H. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 4345-4350
6. Lee, S., Zambas, E. D., Marsh, W. L., and Redman, C. M. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 6353-6357
7. Du, L., Desbarats, M., Viel, J., Glorieux, F. H., Cawthorn, C., and Ecarot, B. (1996) Genomics 36, 22-28
8. Ikeda, K., Emoto, N., Raharjo, S. B., Nurhantari, Y., Saiki, K., Yokoyama, M., and Matsuo, M. (1999) J. Biol. Chem. 274, 32469-32477
9. Ghaddar, G., Ruchon, A. F., Carpentier, M., Marcinkiewicz, M., Seidah, N. G., Crine, P., Desgroseillers, L., and Boileau, G. (2000) Biochem. J. 347, 419-429
10. Ouimet, T., Facchinetti, P., Rose, C., Bonhomme, M. C., Gros, C., Schwartz, J. C., and Tanja, O. (2000) Biochem. Biophys Res. Commun. 271, 565-570
11. Rose, C., Voisin, S., Gros, C., Schwartz, J. C., and Ouimet, T. (2002) Biochem J. 363, 697-705
12. Roques, B. P. (1993) Biochem. Soc. Trans. 3, 678-685
13. Schulz, H., Dale, G. E., Karimi-Nejad, Y., and Oefner, C. (2009) J. Mol. Biol. 385, 178-187
14. Oefner, C., Roques, B. P., Fournie-Zaluski, M. C., and Dale, G. E. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 392-396
15. Roderick, S. L., Fournie-Zaluski, M. C., Roques, B. P., and Matthews, B. W. (1989) Biochemistry 28, 1493-1497
16. Ohnaka, K., Takayanagi, R., Nishikawa, M., Haji, M., and Nawata, H. (1993) J. Biol. Chem. 268, 26759-26766
17. Johnson, G. D., Stevenson, T., and Ahn, K. (1999) J. Biol. Chem. 274, 4053-4058
18. Johnson, G. D., and Ahn, K. (2000) Anal. Biochem. 286, 112-118
19. Luciani, N., de Rocquigny, H., Turcaud, S., Romieu, A., and Roques, B. P. (2001) Biochem. J. 356, 813-819
20. Mzhavia, N., Pan, H., Che, F. Y., Fricker, L. D., and Devi, L. A. (2003) J. Biol. Chem. 278, 14704-14711
21. Selkoe, D. J. (2001) Neuron 32, 177-180
22. Iwata, N., Tsubuki, S., Takaki, Y., Shirotani, K., Lu, B., Gerard, N. P., Gerard, C., Hama, E., Lee, H. J., and Saido, T. C. (2001) Science 292, 1550-1552
23. Eckman, E. A., Watson, M., Marlow, L., Sambamurti, K., and Eckman, C. B. (2003) J. Biol. Chem. 278, 2081-2084
24. Eckman, E. A., Adams, S. K., Troendle, F. J., Stodola, B. A., Kahn, M. A., Fauq, A. H., Xiao, H. D., Bernstein, K. E., and Eckman, C. B. (2006) J. Biol. Chem. 281, 30471-30478
25. Funalot, B., Ouimet, T., Claperon, A., Fallet, C., Delacourte, A., Epelbaum, J., Subkowski, T., Léonard, N., Codron, V., David, J. P., Amouyel, P., Schwartz, J. C., and Helbecque, N. (2004) Mol. Psychiatry 9, 1122-1128
26. Weeraratna, A. T., Kalehua, A., Deleon, I., Bertak, D., Maher, G., Wade, M. S., Lustig, A., Becker, K. G., Wood, W., 3rd, Walker, D. G., Beach, T. G., and Taub, D. D. (2007) Exp. Cell. Res. 313, 450-461
27. Inguimbert, N., Poras, H., Teffo, F., Beslot, F., Selkti, M., Tomas, A., Scalbert, E., Bennejean, C., Renard, P., Fournié-Zaluski, M. C., and Roques, B. P. (2002) Bioorg. Med. Chem. Lett. 12, 2001-2005
28. Inguimbert, N., Coric, P., Poras, H., Meudal, H., Teffot, F., Fournié- Zaluski, M. C., and Roques, B. P. (2002) J. Med. Chem. 45, 1477-1486
29. Gagnidze, K., Sachchidanand, Rozenfeld, R., Mezei, M., Zhou, M. M., and Devi, L. A. (2008) J. Med. Chem. 51, 3378-3387
30. Aubry, M., Berteloot, A., Beaumont, A., Roques, B. P., and Crine, P. (1987) Biochem. Cell. Biol. 65, 398-404
31. Piquilloud, Y., Reinharz, A., and Roth, M. (1970) Biochim. Biophys. Acta 206, 136-142
32. Yanagisawa, H., Hammer, R. E., Richardson, J. A., Emoto, N., Williams, S. C., Takeda, S., Clouthier, D. E., and Yanagisawa, M. (2000) J. Clin. Invest. 105, 1373-1382
33. Rodriguiz, R. M., Gadnidze, K., Ragnauth, A., Dorr, N., Yanagisawa, M., Wetsel, W. C., and Devi, L. A. (2008) Genes Brain Behav. 7, 418-425
34. Roques, B. P. (2000) Trends Pharmacol. Sci. 21, 475-483
35. Roques, B. P., Fournié-Zaluski, M. C., Soroca, E., Lecomte, J. M., Malfroy, B., Llorens, C., and Schwartz, J. C. (1980) Nature 288, 286-288
36. Daull, P., Benrezzak, O., Arsenault, D., Pheng, L. H., Blouin, A., Cayer, J., Beaudoin, M., Belleville, K., Sirois, P., Nantel, F., Jeng, A. Y., and Battistini, B. (2005) Am. J. Hypertens. 18, 1606-1613
37. Fournié-Zaluski, M. C., Gonzalez, W., Turcaud, S., Pham, I., Roques, B. P., and Michel, J. B. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 4072-4076
38. Valeur, B. (2004) Invitation à la Fluorescence Moléculaire, De Boech Université, Brussels, Belgium
39. Ahn, K., Herman, S. B., and Fahnoe, D. C. (1998) Arch. Biochem. Biophys. 359, 258-268
40. Fahnoe, D. C., Knapp, J., Johnson, G. D., and Ahn, K. (2000) J. Cardiovasc. Pharmacol. 36, S22-S25
41. Devault, A., Nault, C., Zollinger, M., Fournie-Zaluski, M. C., Roques, B. P., Crine, P., and Boileau, G. (1988) J. Biol. Chem. 263, 4033-4040
42. Palmer, J. C., Baig, S., Kehoe, P. G., and Love, S. (2009) Am. J. Pathol. 175, 262-270
43. Back, S. A., and Gorenstein, C. (1989) J. Neurosci. 9, 4439-4455