Postnatal docosahexaenoic acid deficiency is an inevitable consequence of current recommendations and practice in preterm infants

Neonatology

Volumn 98, Issue 4, 2010, Pages 397-403

  Lapillonne, Alexandre ^a,b,c   Eleni Dit Trolli, Sergio ^a,b   Kermorvant Duchemin, Elsa ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c Institut de Puericulture   (France)

Author keywords

Docosahexaenoic acid; Growth; Lipid emulsion; Parenteral nutrition; Polyunsaturated fatty acids

Indexed keywords

DOCOSAHEXAENOIC ACID;

ARTICLE; BIRTH WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; ENTERIC FEEDING; ESSENTIAL FATTY ACID DEFICIENCY; FAT INTAKE; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; FEMALE; GESTATIONAL AGE; HUMAN; INFANT; LIPID ABSORPTION; LIPID STORAGE; MALE; NEWBORN; PARENTERAL NUTRITION; PREMATURITY; PRIORITY JOURNAL;

DOCOSAHEXAENOIC ACIDS; ENERGY INTAKE; GESTATIONAL AGE; HUMANS; INFANT FOOD; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; INFANT, PREMATURE; NUTRITION DISORDERS; NUTRITION POLICY; PARENTERAL NUTRITION, TOTAL;

EID: 78049381991     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000320159     Document Type: Article

References (28)

1. Lauritzen L, Hansen HS, Jorgensen MH, et al: The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 2001; 40:1-94.
2. Heird WC, Lapillonne A: The role of essential fatty acids in development. Annu Rev Nutr 2005; 25: 549-571.
3. Uauy R, Rojas C, Llanos A, et al: Dietary essential fatty acids in early postnatal life: longterm outcomes. Nestle Nutr Workshop Ser Pediatr Program 2005; 55: 101-133, d i s -cussion 134-106.
4. Innis SM: Essential fatty acid transfer and feta l development. Placenta 20 05; 26(Suppl A):S70-S75.
5. Haggarty P: Effect of placental function on fatty acid requirements during pregnancy. Eur J Clin Nut r 2004; 58: 1559-1570.
6. Larque E, Krauss-Etschmann S, Campoy C, et al: Docosahexaenoic acid supply in pregnancy affects placental expression of fatty acid transport proteins. Am J Clin Nutr 2006; 84: 853-861.
7. Lapillonne A, Jensen CL: Reevaluation of the DHA requirement for the premature infant. Prostaglandins Leukot Essent Fatty Acids 2009; 81: 143-150.
8. Klein CJ: Nutrient requirements for preterm infant formulas. J Nutr 2002; 132: 1395S-1577S.
9. Agostoni C, Buonocore G, Carnielli VP, et al: Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010; 50:85-91.
10. Makrides M, Gibson RA, McPhee AJ, et al: Neurodevelopmental outcomes of preterm infants fed highdose docosahexaenoic acid: a randomized controlled trial. JAMA 2009; 301: 175-182.
11. Smithers LG, Gibson RA, McPhee A, et al: Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial. Am J Clin Nutr 2008; 88: 1049-1056.
12. Henrik sen C, Haugholt K, Lindg ren M, et a l: Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid. Pediatrics 2008; 121: 1137-1145.
13. Koletzko B, Goulet O, Hunt J, et a l: 1. Guidelines on Paediatric Parenteral Nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ES-PEN), Supported by the European Society of Paediatric Research (ESPR). J Pediatr Gastroenterol Nutr 2005; 41(Suppl 2):S1-S87.
14. Gobel Y, Koletzko B, Bohles HJ, et al: Parenteral fat emulsions based on olive and soybean oils: a randomized clinical trial in preterm infants. J Pediatr Gastroenterol Nutr 2003; 37: 161-167.
15. Sauerwald TU, Hachey DL, Jensen CL, et al: Intermediates in endogenous synthesis of C22: 6 omega 3 and C20: 4 omega 6 by term and preterm infants. Pediatr Res 1997; 41: 183-187.
16. Carnielli VP, Simonato M, Verlato G, et al: Synthesis of longchain polyunsaturated fatty acids in preterm newborns fed formula with longchain polyunsaturated fatty acids. Am J Clin Nutr 2007; 86: 1323-1330.
17. Carnielli VP, Wattimena DJ, Luijendijk IH, et al: The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. Pediatr Res 1996; 40: 169-174.
18. Lapillonne A, Picaud JC, Chirouze V, et al: The use of low-EPA fish oil for longchain polyunsaturated fatty acid supplementation of preterm infants. Pediatr Res 2000; 48: 835-841.
19. Amusquivar E, Sanchez M, Hyde MJ, et al: Influence of fatty acid profile of total parenteral nutrition emulsions on the fatty acid composition of different tissues of piglets. Lipids 2008; 43: 713-722 .
20. Carnielli VP, Verlato G, Pederzini F, et al: Intestinal absorption of longchain polyunsaturated fatty acids in preterm infants fed breast milk or for mula. Am J Clin Nutr 19 98; 67:97-103.
21. Uauy R, Mena P, Wegher B, et al: Long chain polyunsaturated fatty acid formation in neonates: effect of gestational age and intrauterine grow th. Pediatr Res 2000; 47: 127-135.
22. Descomps B, Rodriguez A: Essential fatty acids and prematurity: a triple experimental approach (in French). CR Seances Soc Biol Fil 1995; 189: 781-796.
23. Lehner F, Demmelmair H, Roschinger W, et al: Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. J Lipid Res 2006; 47:404-411.
24. Brenna JT, Varamini B, Jensen RG, et al: Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 2007; 85:1457-1464.
25. Lapillonne A, Brossard N, Claris O, et al: Erythrocyte fatty acid composition in term infants fed human milk or a formula enriched with a low eicosapentanoic acid fish oil for 4 months. Eur J Pediatr 2000; 159:49-53.
26. Farquharson J, Cockburn F, Patrick WA, et al: Effect of diet on infant subcutaneous tissue triglyceride fatty acids. Arch Dis Child 19 93; 69: 589-593.
27. Cunnane SC, Francescutti V, Brenna JT, et al: Breastfed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formulafed infants not consuming dietary docosahexaenoate. Lipids 2000; 35: 105-111.
28. Smithers LG, Gibson RA, McPhee A, et al: Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trial. Prostaglandins Leukot Essent Fatty Acids 2008; 79: 141-146.