Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice

European Journal of Applied Physiology

Volumn 110, Issue 4, 2010, Pages 797-803

  Yano, Hiromi ^a   Uchida, Masataka ^a,b   Nakai, Ryosuke ^a   Ishida, Kenji ^a   Kato, Yasuko ^a   Kawanishi, Noriaki ^c   Shiva, Daisuke ^d  

^a KAWASAKI UNIVERSITY OF MEDICAL WELFARE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c WASEDA UNIVERSITY   (Japan)

^d KURASHIKI UNIVERSITY OF SCIENCE AND THE ARTS   (Japan)

Author keywords

C3H HeN mice; Immune depression; Pro inflammatory cytokine; ssRNA; TLR7; Type I interferon

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA INTERFERON; IMIDAZOLE DERIVATIVE; MEMBRANE PROTEIN; NORADRENALIN; RESIQUIMOD; TLR7 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BLOOD; C3H MOUSE; CELL LINE; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; EXERCISE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MACROPHAGE; MALE; METABOLISM; MOUSE; PHYSIOLOGY;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CELL LINE; EPINEPHRINE; IMIDAZOLES; IMMUNE TOLERANCE; INTERFERON-ALPHA; MACROPHAGES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; NOREPINEPHRINE; PHYSICAL EXERTION; TOLL-LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78049350679     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-010-1560-1     Document Type: Article

References (39)

1. S Akira K Takeda 2004 Functions of toll-like receptors: lessons from KO mice C R Biol 327 581 589 1:CAS:528:DC%2BD2cXls1Wlt7c%3D 10.1016/j.crvi.2004.04. 002 15330257 (Pubitemid 38979508)
2. S Akira S Uematsu O Takeuchi 2006 Pathogen recognition and innate immunity Cell 124 783 801 10.1016/j.cell.2006.02.015 1:CAS:528: DC%2BD28Xit1Kltb8%3D 10.1016/j.cell.2006.02.015 16497588 (Pubitemid 43261452)
3. GJ Bagby DE Sawaya LD Crouch RE Shepherd 1994 Prior exercise suppresses the plasma tumor necrosis factor response to bacterial lipopolysaccharide J Appl Physiol 77 1542 1547 1:CAS:528:DyaK2cXmslymsbs%3D 7836163
4. MA Ceddia JA Woods 1999 Exercise suppresses macrophage antigen presentation J Appl Physiol 87 2253 2258 1:CAS:528:DC%2BD3cXlsleltQ%3D%3D 10601175
5. LM Chiang YJ Chen J Chiang LY Lai YY Chen HF Liao 2007 Modulation of dendritic cells by endurance training Int J Sports Med 28 798 803 10.1055/s-2007-964914 1:CAS:528:DC%2BD2sXhtFanurzI 10.1055/s-2007-964914 17436203 (Pubitemid 47414173)
6. A Collado-Hidalgo C Sung S Cole 2006 Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catecholamine support for HIV-1 replication Brain Behav Immun 20 552 563 10.1016/j.bbi.2006.01.005 1:CAS:528:DC%2BD28XhtVyitrvI 10.1016/j.bbi.2006. 01.005 16504464 (Pubitemid 44528951)
7. M Colonna A Krug M Cella 2002 Interferon-producing cells: on the front line in immune responses against pathogens Curr Opin Immunol 14 373 379 10.1016/S0952-7915(02)00349-7 1:CAS:528:DC%2BD38XjtVeitLs%3D 10.1016/S0952-7915(02)00349-7 11973137 (Pubitemid 34327981)
8. JM Davis ML Kohut LH Colbert DA Jackson A Ghaffar EP Mayer 1997 Exercise, alveolar macrophage function, and susceptibility to respiratory infection J Appl Physiol 83 1461 1466 1:STN:280:DyaK1c%2Fkt1yktA%3D%3D 9375306
9. IJ Elenkov GP Chrousos 2002 Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity Ann NY Acad Sci 966 290 303 1:CAS:528:DC%2BD38XlvVWmur0%3D 10.1111/j.1749-6632.2002.tb04229.x 12114286
10. SJ Gibson JM Lindh TR Riter RM Gleason LM Rogers AE Fuller JL Oesterich KB Gorden X Qiu SW McKane RJ Noelle RL Miller RM Kedl P Fitzgerald-Bocarsly MA Tomai JP Vasilakos 2002 Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod Cell Immunol 218 74 86 10.1016/S0008-8749(02)00517-8 1:CAS:528:DC%2BD38XpsF2ksbc%3D 10.1016/S0008-8749(02)00517-8 12470615 (Pubitemid 36027092)
11. M Gleeson B McFarlin M Flynn 2006 Exercise and toll-like receptors Exerc Immunol Rev 12 34 53 17201071
12. E Goyarts M Matsui T Mammone AM Bender JA Wagner D Maes RD Granstein 2008 Norepinephrine modulates human dendritic cell activation by altering cytokine release Exp Dermatol 17 188 196 10.1111/j.1600-0625.2007.00677.x 1:CAS:528:DC%2BD1cXjtlensro%3D 10.1111/j.1600-0625.2007.00677.x 18205818 (Pubitemid 351233863)
13. F Heil H Hemmi H Hochrein F Ampenberger C Kirschning S Akira G Lipford H Wagner S Bauer 2004 Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8 Science 303 1526 1529 10.1126/science.1093620 1:CAS:528:DC%2BD2cXhslCgsLc%3D 10.1126/science.1093620 14976262 (Pubitemid 38314424)
14. H Hemmi T Kaisho O Takeuchi S Sato H Sanjo K Hoshino T Horiuchi H Tomizawa K Takeda S Akira 2002 Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway Nat Immunol 3 196 200 10.1038/ni758 1:CAS:528:DC%2BD38XhtVygurc%3D 10.1038/ni758 11812998 (Pubitemid 34141451)
15. CS Ho JA López S Vuckovic CM Pyke RL Hockey DN Hart 2001 Surgical and physical stress increases circulating blood dendritic cell counts independently of monocyte counts Blood 98 140 145 1:CAS:528:DC%2BD3MXkvFSmu7Y%3D 10.1182/blood.V98.1.140 11418473
16. TA Ignatowski S Gallant RN Spengler 1996 Temporal regulation by adrenergic receptor stimulation of macrophage (M Φ)-derived tumor necrosis factor (TNF) production post-LPS challenge J Neuroimmunol 65 107 117 1:CAS:528:DyaK28XjsVymtLk%3D 10.1016/0165-5728(96)00004-5 8964892
17. T Ito R Amakawa T Kaisho H Hemmi K Tajima K Uehira Y Ozaki H Tomizawa S Akira S Fukuhara 2002 Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets J Exp Med 195 1507 1512 10.1084/jem.20020207 1:CAS:528: DC%2BD38XktlGhsbw%3D 10.1084/jem.20020207 12045249 (Pubitemid 34602828)
18. M Jurk F Heil J Vollmer C Schetter AM Krieg H Wagner G Lipford S Bauer 2002 Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848 Nat Immunol 3 499 10.1038/ni0602-499 1:CAS:528: DC%2BD38XjvFOmsLo%3D 10.1038/ni0602-499 12032557 (Pubitemid 34669818)
19. A Karlsson K Jägervall H Utkovic L Karlsson E Rehnström MF Fredin PG Gillberg L Jansson E Michaëlsson S Melgar 2008 Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice Biochem Biophys Res Commun 367 242 248 10.1016/j.bbrc.2007. 12.046 1:CAS:528:DC%2BD1cXpsFyhug%3D%3D 10.1016/j.bbrc.2007.12.046 18083110
20. T Kato S Kaneko R Kimizuka K Okuda 2006 Periodontopathic bacterial endotoxin- induced tumor necrosis factor alpha production was inhibited by exercise in mice FEMS Immunol Med Microbiol 47 262 266 10.1111/j.1574-695X.2006. 00075.x 1:CAS:528:DC%2BD28Xms1CntrY%3D 10.1111/j.1574-695X.2006.00075.x 16831213 (Pubitemid 43881746)
21. H Kitamura D Shiva JA Woods H Yano 2007 Beta-adrenergic receptor blockade attenuates the exercise-induced suppression of TNF-alpha in response to LPS in rats NeuroImmunoModulation 14 91 96 10.1159/000107424 1:CAS:528: DC%2BD2sXhtVGkurvL 10.1159/000107424 17713356 (Pubitemid 47442987)
22. ML Kohut GW Boehm JA Moynihan 2001 Prolonged exercise suppresses antigen-specific cytokine response to upper respiratory infection J Appl Physiol 90 678 684 1:CAS:528:DC%2BD3MXjsVWltr0%3D 11160069
23. K Krüger A Lechtermann M Fobker K Völker FC Mooren 2008 Exercise-induced redistribution of T lymphocytes is regulated by adrenergic mechanisms Brain Behav Immun 22 324 338 10.1016/j.bbi2007.08.008 10.1016/j.bbi.2007.08.008 17910910
24. GI Lancaster Q Khan PT Drysdale F Wallace AE Jeukendrup MT Drayson M Gleeson 2005 Effect of prolonged strenuous exercise and carbohydrate ingestion on type 1 and type 2 T lymphocyte distribution and intracellular cytokine production in humans J Appl Physiol 98 565 571 1:CAS:528:DC%2BD2MXhsVKmtLg%3D 10.1152/japplphysiol.00754.2004 15322070 (Pubitemid 40129966)
25. GI Lancaster Q Khan P Drysdale F Wallace AE Jeukendrup MT Drayson M Gleeson 2005 The physiological regulation of toll-like receptor expression and function in humans J Physiol 563 945 955 10.1113/jphysiol.2004.081224 1:CAS:528:DC%2BD2MXivVGhtbk%3D 10.1113/jphysiol.2004.081224 15661814 (Pubitemid 40425607)
26. MA Mayo CR Pringle 1998 Virus taxonomy-1997 J Gen Virol 79 649 657 1:CAS:528:DyaK1cXit1Wnu7c%3D 9568957
27. BK McFarlin MG Flynn WW Campbell LK Stewart KL Timmerman 2004 TLR4 is lower in resistance-trained older women and related to inflammatory cytokines Med Sci Sports Exerc 36 1876 1883 1:CAS:528:DC%2BD2cXptV2jtbk%3D 10.1249/01.MSS.0000145465.71269.10 15514501 (Pubitemid 39473505)
28. EA Murphy JM Davis MD Carmichael JD Gangemi A Ghaffar EP Mayer 2008 Exercise stress increases susceptibility to influenza infection Brain Behav Immun 22 1152 1155 10.1016/j.bbi.2008.06.004 1:STN:280:DC%2BD1MjitlOjtg%3D%3D 10.1016/j.bbi.2008.06.004 18616997
29. DC Nieman 1994 Exercise, upper respiratory tract infection, and the immune system Med Sci Sports Exerc 26 128 139 1:STN:280:DyaK2c3hslCrsw%3D%3D 10.1249/00005768-199402000-00002 8164529
30. DB Pyne M Gleeson WA McDonald RL Clancy C Perry Jr PA Fricker 2000 Neutrophil oxidative activity is differentially affected by exercise intensity and type Int J Sports Med 21 S51 S60 10.1055/s-2000-1452 10893025
31. A Schoenemeyer BJ Barnes ME Mancl E Latz N Goutagny PM Pitha KA Fitzgerald DT Golenbock 2005 The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling J Biol Chem 280 17005 17012 10.1074/jbc.M412584200 1:CAS:528:DC%2BD2MXjsFOgtrY%3D 10.1074/jbc.M412584200 15695821 (Pubitemid 41389162)
32. RJ Simpson BK McFarlin C McSporran G Spielmann B ó Hartaigh K Guy 2009 Toll-like receptor expression on classic and pro-inflammatory blood monocytes after acute exercise in humans Brain Behav Immun 23 232 239 10.1016/j.bbi.2008.09.013 1:CAS:528:DC%2BD1MXhtFSntLo%3D 10.1016/j.bbi.2008.09. 013 18930806
33. J Siren J Pirhonen I Julkunen S Matikainen 2005 IFN-α regulates TLR-dependent gene expression of IFN-α, IFN-β, IL-28, and IL-29 J Immunol 174 1932 1937 1:CAS:528:DC%2BD2MXhtV2rsrc%3D 15699120
34. LK Stewart MG Flynn WW Campbell BA Craig JP Robinson BK McFarlin KL Timmerman PM Coen J Felker E Talbert 2005 Influence of exercise training and age on CD14+ cell-surface expression of toll-like receptor 2 and 4 Brain Behav Immun 19 389 397 10.1016/j.bbi.2005.04.003 1:CAS:528:DC%2BD2MXntVGjur8%3D 10.1016/j.bbi.2005.04.003 15963685 (Pubitemid 41074777)
35. KF Tanaka H Kashima H Suzuki K Ono M Sawada 2002 Existence of functional beta1- and beta2-adrenergic receptors on microglia J Neurosci Res 70 232 237 10.1002/jnr.10399 1:CAS:528:DC%2BD38XnvFSltbc%3D 10.1002/jnr.10399 12271472
36. Y Tanaka N Kawanishi D Shiva N Tsutsumi M Uchida H Kitamura Y Kato H Yano 2010 Exhaustive exercise reduces tumor necrosis factor-alpha production in response to lipopolysaccharide in mice NeuroImmunoModulation 17 279 286 10.1159/000290044 1:CAS:528:DC%2BC3cXjslShtbY%3D 10.1159/000290044 20203534
37. A Viti M Muscettola L Paulesu V Bocci A Almi 1985 Effect of exercise on plasma interferon levels J Appl Physiol 59 426 428 1:CAS:528:DyaL2MXlt1Wntr4%3D 2411709 (Pubitemid 15249870)
38. JA Woods 2000 Exercise and neuroendocrine modulation of macrophage function Int J Sports Med 21 S24 S30 1:CAS:528:DC%2BD3cXktlWkuro%3D 10.1055/s-2000-1448 10893021
39. RB Zinyama GJ Bancroft LB Sigola 2001 Adrenaline suppression of the macrophage nitric oxide response to lipopolysaccharide is associated with differential regulation of tumor necrosis factor-alpha and interleukin-10 Immunology 104 439 446 1:CAS:528:DC%2BD3MXpt1Sisrg%3D 10.1046/j.1365-2567.2001. 01332.x 11899430 (Pubitemid 34037837)