Norepinephrine modulates human dendritic cell activation by altering cytokine release

Experimental Dermatology

Volumn 17, Issue 3, 2008, Pages 188-196

  Goyarts, Earl ^a   Matsui, Mary ^a   Mammone, Tom ^a   Bender, Anna M ^b   Wagner, John A ^b   Maes, Daniel ^a   Granstein, Richard D ^b  

^a Clinique Laboratories   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Beta adrenergic receptor; Cytokines; Dendritic cells; Norepinephrine; Stress

Indexed keywords

ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CD34 ANTIGEN; CYCLIC AMP; FORSKOLIN; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 23; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NORADRENALIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELLULAR IMMUNITY; CONTACT ALLERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; PROTEIN EXPRESSION; TH1 CELL; UMBILICAL CORD BLOOD;

ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTIGENS, CD34; CELLS, CULTURED; DENDRITIC CELLS; FETAL BLOOD; FORSKOLIN; HUMANS; INTERLEUKINS; LIPOPOLYSACCHARIDES; MICE; NOREPINEPHRINE; SYMPATHOMIMETICS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 39049117323     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2007.00677.x     Document Type: Article

References (68)

1. Hosoi J, Tsuchiya T, Denda M et al. Modification of LC phenotype and suppression of contact hypersensitivity response by stress. J Cutan Med Surg 1998: 3: 79-84.
2. Saint-Mezard P, Chavagnac C, Bosset S et al. Psychological stress exerts an adjuvant effect on skin dendritic cell functions in vivo. J Immunol 2003: 171: 4073-4080.
3. Dhabhar F S, McEwen B S. Enhancing versus suppressive effects of stress hormones on skin immune function. Proc Natl Acad Sci USA 1999: 96: 1059-1064.
4. Glaser R, Kiecolt-Glaser J K. Stress-induced immune dysfunction: implications for health. Nature Rev Immunol 2005: 5: 243-251.
5. Webster J I, Tonelli L, Sternberg E M. Neuroendocrine regulation of immunity. Ann Rev Immunol 2002: 20: 125-163.
6. Elenkov I J, Wilder R L, Chrousos G P, Vizi E S. The sympathetic nerve: an integrative interface between two supersystems: The brain and the immune system. Pharmacol Rev 2000: 52: 595-638.
7. Elenkov I J, Chrousos G P, Wilder R L. Neuroendocrine regulation of IL-12 and TNF-alpha/IL-10 balance. Clinical implications. Ann N Y Acad Sci 2000: 917: 94-105.
8. Elenkov I J, Chrousos G P. Stress hormones, proinflammatory and anti-inflammatory cytokines, and autoimmunity. Ann N Y Acad Sci 2002: 966: 290-303.
9. Maestroni G J M. Adrenergic modulation of dendritic cells function: relevance for the immune homeostasis. Curr Neurovascul Res 2005: 2: 169-173.
10. Hosoi J, Murphy G F, Egan C L et al. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 1993: 363: 159-163.
11. Seiffert K, Granstein R D. Neuroendocrine regulation of skin dendritic cells. Ann N Y Acad Sci 2006: 1088: 195-206.
12. Schallreuter K U, Lemke K R, Pittelkow M R, Wood J M, Korner C, Malik R. Catecholamines in human keratinocyte differentiation. J Invest Dermatol 1995: 104: 953-957.
13. Gillbro J M, Marles L K, Hibberts N A, Schallreuter K U. Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes. J Invest Dermatol 2004: 123: 346-353.
14. Schallreuter K U, Wood J M, Lemke R et al. Production of catecholamines in the human epidermis. Biochem Biophys Res Commun 1992: 189: 72-78.
15. Steinkraus V, Steinfath M, Körner C, Mensing H. Binding of beta-adrenergic receptors in human skin. J Invest Dermatol 1992: 98: 475-480.
16. Grando S A, Pittelkow M R, Schallreuter K U. Adrenergic and cholinergic control in the biology of epidermis: Physiological and clinical significance. J Invest Dermatol 2006: 126: 1948.
17. 2 in response to nicotinic acid. J Invest Dermatol 2006: 126: 2637-2646.
18. Kissenpfennig A, Malissen B. Langerhans cells - revisiting the paradigm using genetically engineered mice. Trends Immunol 2006: 27: 132-139.
19. Larregina A T, Falo L D. Changing paradigms in cutaneous immunology: adapting with dendritic cells. J Invest Dermtol 2005: 124: 1-12.
20. Kaplan D H, Jenison M C, Saeland S, Shlomchik W D, Shlomchik M J. Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 2005: 23: 611-620.
21. Ritter U, Osterloh A. A new view on cutaneous dendritic cell subsets in experimental leishmaniasis. Med Microbiol Immunol (Berl) 2007: 196: 51-59.
22. Kissenpfennig A, Henri S, Dubois B et al. Dynamics and function of Langerhans cells in vivo: Dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 2005: 22: 643-654.
23. Seiffert K, Hosoi J, Torii H et al. Catecholamines inhibit the antigen-presenting capability of epidermal Langerhans cells. J Immunol 2002: 168: 6128-6135.
24. Maestroni G J M. Short exposure of maturing, bone marrow-derived dendritic cells to norepinephrine: Impact on kinetics of cytokine production and Th development. J Neuroimmunol 2002: 129: 106-114.
25. Maestroni G J M, Mazzola P. Langerhans cells β2-adrenoceptors: Role in migration, cytokine production, Th priming and contact hypersensitivity. J Neuroimmunol 2003: 144: 91-99.
26. Cavrois M, Neidleman J, Kreisberg J F, Greene W C. In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Pathog 2007: 3: 38-45.
27. Fahrbach K M, Barry S M, Ayehunie S, Lamore S, Klausner M, Hope T J. Activated CD34 derived Langerhans cells mediate trans-infection of HIV. J Virol 2007: 81: 6858-6868.
28. Valladeau J, Ravel O, Dezutter-Dambuyant C et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 2000: 12: 71-81.
29. D'Andrea A, Rengaraju M, Valiante N M et al. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 1992: 176: 1387-1398.
30. Abdi K, Singh N, Matzinger P. T-cell control of IL-12p75 production. Scand J Immunol 2006: 64: 83-92.
31. Ling P, Gately M K, Gubler U et al. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol 1995: 154: 116-127.
32. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003: 3: 133-146.
33. Klinke D J. The ratio of P40 monomer to dimer is an important determinant of IL-12 bioactivity. J Theor Biol 2006: 240: 323-335.
34. Jakob T, Walker P S, Krieg A M, Udey M C, Vogel J C. Activation of cutaneous dendritic cells by CpG-containing oligonucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J Immunol 1998: 161: 3042-3049.
35. Ding W, Wagner J A, Granstein R D. CGRP, PACAP, and VIP modulate Langerhans cell function by inhibiting NF-κB activation. J Invest Dermatol 2007; DOI:10.1038 (online).
36. La Sala A, Ferrari D, Corinti S, Cavani A, Di Virgilio F, Girolomoni G. Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses. J Immunol 2001: 166: 1611-1617.
37. Flacher V, Bouschbacher M, Verronèse E et al. Human Langerhans cells express a specific TLR profile and differentially respond to viruses and gram-positive bacteria. J Immunol 2006: 177: 7959-7967.
38. van der Aar A M G, Sylva-Steenland R M R, Bos J D, Kapsenberg M L, de Jong E C, Teunissen M B M. Cutting edge: Loss of TLR2, TLR4, and TL5 on Langerhans cells abolishes bacterial recognition. J Immunol 2007: 178: 1986-1990.
39. Caux C, Dezutter-Dambuyant, Schmitt D, Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 1992: 360: 258-261.
40. Caux C, Massacrier C, Vanbervliet B et al. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha: II. Functional analysis. Blood 1997: 90: 1458-1470.
41. Re F, Strominger J L. IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLF3 in human dendritic cells. J Immunol 2004: 173: 7548-7555.
42. Qi H, Denning T L, Soong L. Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T cell cytokine profiles. Infect Immun 2003: 71: 3337-3342.
43. Maestroni G J M. Sympathetic nervous system influence on the innate immune response. Ann NY Acad Sci 2006: 1069: 195-207.
44. 2-adrenergic receptor in children with asthma. Proc Natl Acad Sci USA 2006: 103: 5496-5501.
45. O'Kane M, Murphy E P, Kirby B. The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease. Exp Dermatol 2006: 15: 143-153.
46. Obreja O, Rukwied R, Steinhoff M, Schmelz M. Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo. Exp Dermatol 2006: 15: 58-65.
47. Morelli A E, Zahorchak A F, Larregina A T et al. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood 2001: 98: 1512-1523.
48. Luft T, Jefford M, Luetjens P et al. IL-1β enhances CD40 ligand-mediated cytokine secretion by human dendritic cells (DC): A mechanism for T cell-independent DC activation. J Immunol 2002: 168: 713-722.
49. Luft T, Luetjens P, Hochrein H et al. INF-α enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells. Int Immunol 2002: 14: 367-380.
50. Peiser M, Wanner R, Kolde G. Human epidermal Langerhans cells differ from monocyte-derived Langerhans cells in CD80 expression and in secretion of IL-12 after CD40 cross-linking. J Leukoc Biol 2004: 76: 616-622.
51. Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol 2006: 6: 476-483.
52. Mazzoni A, Segal D M. Controlling the Toll road to dendritic cell polarization. J Leukoc Biol 2004: 75: 721-730.
53. Morelli A E, Rubin J P, Erdos G et al. CD4+ T cell responses elicited by different subsets of human skin migratory dendritic cells. J Immunol 2005: 175: 7905-7915.
54. Kurimoto I, Streilein J W. Tumor necrosis factor-alpha impairs contact hypersensitivity induction after ultraviolet B radiation via TNF-receptor 2 (p75). Exp Dermatol 1999: 8: 495-500.
55. Piguet P F, Grau G E, Hauser C, Vassalli P. Tumor necrosis factor is a critical mediator in hapten induced irritant and contact hypersensitivity reactions. J Exp Med 1991: 173: 673-679.
56. Maestroni G J. Modulation of skin norepinephrine turnover by allergen sensitization: Impact on contact hypersensitivity and T helper priming. J Invest Dermatol 2004: 122: 119-124.
57. Kishimoto T. Interleukin-6: From basic science to medicine - 40 years in immunology. Ann Rev Immunol 2005: 23: 1-21.
58. Bethin K E, Vogt S K, Muglia L J. Interleukin-6 is an essential, corticotrophin-releasing hormone-independent stimulator of the adrenal axis during immune system activation. Proc Natl Acad Sci USA 2000: 97: 9317-9322.
59. Inaba K, Inaba M, Romani N et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992: 176: 1693-1702.
60. Bastos K R B, Marinho C R F, Barboza R, Russo M, Álvarez J M, Lima M R. What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells? Microb Infect 2004: 6: 630-636.
61. Hunter C A. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 2005: 5: 521-531.
62. Lankford C S R, Frucht D M. A unique role for IL-23 in promoting cellular immunity. J Leukoc Biol 2003: 73: 49-56.
63. Trinchieri G, Pflanz S, Kastelein R A. The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses. Immunity 2003: 19: 641-644.
64. Langrish C L, McKenzie B S, Wilson N J, de Waal Malefyt R, Kastelein R A, Cua D J. IL-12 and IL-23: Master regulators of innate and adaptive immunity. Immunol Rev 2004: 202: 96-105.
65. Kastelein R A, Hunter C A, Cua D J. Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation. Annu Rev Immunol 2007: 25: 221-242.
66. Oppmann B, Lesley R, Blom B et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000: 13: 715-725.
67. Lee E, Trepicchio W L, Oestreicher J L et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 2004: 199: 125-130.
68. Frohman E M, Vayuvegula B, Gupta S, Van Den Noort S. Norepinephrine inhibits gamma interferon-induced major histocompatibility class II (Ia) antigen expression on cultured astrocytes via beta-2-adrenergic signal transduction mechanisms. Proc Natl Acad Sci USA 1988: 85: 1292-1296.