Effect of Alcohol on Drug Efflux Protein and Drug Metabolic Enzymes in U937 Macrophages

Alcoholism: Clinical and Experimental Research

Volumn 35, Issue 1, 2011, Pages 132-139

  Jin, Mengyao ^a   Arya, Priyanka ^a   Patel, Kalpeshkumar ^a   Singh, Bhupendra ^a   Silverstein, Peter S ^a   Bhat, Hari K ^a   Kumar, Anil ^a   Kumar, Santosh ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

ABCC1; Alcohol; Antiretroviral Therapy; Cytochrome P450; Oxidative Stress

Indexed keywords

ABC TRANSPORTER; ALCOHOL; CATALASE; CYTOCHROME P450 1A1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; MESSENGER RNA; PROTEIN ABCC1; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN U937; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MACROPHAGE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANTI-HIV AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOCHROME P-450 ENZYME SYSTEM; ETHANOL; HIV PROTEASE INHIBITORS; HUMANS; MACROPHAGES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE INHIBITORS; U937 CELLS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78049301817     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01330.x     Document Type: Article

References (43)

1. Anzenbacher P, Anzenbacherová E (2001) Cytochromes P450 and metabolism of xenobiotics. Cell Mol Life Sci 58:737-747.
2. Aquaro S, Balestra E, Cenci A, Francesconi M, Caliò R, Perno CF (1997) HIV infection in macrophage: role of long-lived cells and related therapeutical strategies. J Biol Regul Homeost Agents 11:69-73.
3. Aquaro S, Svicher V, Schols D, Pollicita M, Antinori A, Balzarini J, Perno CF (2006) Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: new therapeutic strategies. J Leukoc Biol 80:1103-1110.
4. Bautista AP (2001) Free radicals, chemokines, and cell injury in HIV-1 and SIV infections and alcoholic hepatitis. Free Radic Biol Med 31:1527-1532.
5. Cole SP, Deeley RG (2010) Transport of glutathione and glutathione conjugates by MRP1. Trends Pharmacol Sci 27:438-446.
6. Deeley RG, Westlake C, Cole SP (2006) Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 86:849-899.
7. Flexner CW, Cargill VA, Sinclair J, Kresina TF, Cheever L (2001) Alcohol use can result in enhanced drug metabolism in HIV pharmacotherapy. AIDS Patient Care STDS 15:57-58.
8. Floreani NA, Rump TJ, Muneer PM, Alikunju S, Morsey BM, Brodie MR, Persidsky Y, Haorah J (2010) Alcohol-induced interactive phosphorylation of Src and toll-like receptor regulates the secretion of inflammatory mediators by human astrocytes. J Neuroimmune Pharmacol. DOI: .
9. Freeman TL, Chadwick AP, Lennard MS, Martin CM, Turcan RG, Blond D (2007) Characterisation of the induction of cytochrome p450 enzymes in primary cultures of human hepatocytes, in Cell Technology for Cell Products (Smith R ed), pp 67-70. Springer, Netherlands.
10. Fukami T, Katoh M, Yamazaki H, Yokoi T, Nakajima M (2008) Human cytochrome P450 2A13 efficiently metabolizes chemicals in air pollutants: naphthalene, styrene, and toluene. Chem Res Toxicol 21:720-725.
11. Gómez-Lechón MJ, Castell JV, Donato MT (2008) An update on metabolism studies using human hepatocytes in primary culture. Expert Opin Drug Metab Toxicol 4:837-854.
12. Guizzetti M, Chen J, Oram JF, Tsuji R, Dao K, Möller T, Costa LG (2007) Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes. J Biol Chem 282:18740-18749.
13. Haorah J, Heilman D, Diekmann C, Osna N, Donohue TM Jr, Ghorpade A, Persidsky Y (2004) Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease. Cell Immunol 229:139-148.
14. Haorah J, Ramirez SH, Floreani N, Gorantla S, Morsey B, Persidsky Y (2009) Mechanism of alcohol-induced oxidative stress and neuronal injury. Free Radic Biol Med 45:1542-1550.
15. Harlow GR, Halpert JR (1997) Alanine-scanning mutagenesis of putative substrate recognition sites in human cytochrome P4503A4. J Biol Chem 272:5396-5402.
16. Hutson JL, Wickramasinghe SN (1999) Expression of CYP2E1 by human monocyte-derived macrophages. J Pathol 188:197-200.
17. Igarashi T, Brown CR, Endo Y, Buckler-White A, Plishka R, Bischofberger N, Hirsch V, Martin MA (2001) Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): implications for HIV-1 infections of humans. Proc Natl Acad Sci U S A 98:658-663.
18. Kalichman SC, Amaral CM, White D, Swetsze C, Pope H, Kalichman MO, Cherry C, Eaton L (2009) Prevalence and clinical implications of interactive toxicity beliefs regarding mixing alcohol and antiretroviral therapies among people living with HIV/AIDS. AIDS Patient Care STDS 23:449-454.
19. Kedzierska K, Crowe SM (2002) The role of monocytes and macrophages in the pathogenesis of HIV-1 infection. Curr Med Chem 9:1893-1903.
20. Kerb R, Hoffmeyer S, Brinkmann U (2001) ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. Pharmacogenomics 2:51-64.
21. Kresina TF, Flexner CW, Sinclair J, Correia MA, Stapleton JT, Adeniyi-Jones S, Cargill V, Cheever LW (2002) Alcohol use and HIV pharmacotherapy. AIDS Res Hum Retroviruses 18:757-770.
22. Kumar S, Liu H, Halpert JR (2006) Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis. Drug Metab Dispos 34:1958-1965.
23. 264→Phe substitution. Mol Pharmacol 46:11559-11567.
24. Langmann T, Mauerer R, Schmitz G (2006) Human ATP-binding cassette transporter TaqMan low-density array: analysis of macrophage differentiation and foam cell formation. Clin Chem 52:310-313.
25. Lee CG, Gottesman MM, Cardarelli CO, Ramachandra M, Jeang KT, Ambudkar SV, Pastan I, Dey S (1998) HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry 37:3594-3601.
26. Lee WY, Lee SM (2003) Differential regulation of cytochrome P450 isozyme mRNAs and proteins by femur fracture trauma. Arch Pharm Res 26:1079-1086.
27. Louis CA, Wood SG, Kostrubsky V, Sinclair PR, Sinclair JF (1994) Synergistic increases in rat hepatic cytochrome P450s by ethanol and isopentanol. J Pharmacol Exp Ther 269:838-845.
28. Lu Y, Cederbaum AI (2008) CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 44:723-738.
29. McCartney EM, Semendric L, Helbig KJ, Hinze S, Jones B, Weinman SA, Beard MR (2008) Alcohol metabolism increases the replication of hepatitis C virus and attenuates the antiviral action of interferon. J Infect Dis 198:1766-1775.
30. Miguez MJ, Shor-Posner G, Morales G, Rodriguez A, Burbano X (2003) HIV treatment in drug abusers: impact of alcohol use. Addict Biol 8:33-37.
31. Montaner LJ, Crowe SM, Aquaro S, Perno CF, Stevenson M, Collman RG (2006) Advances in macrophage and dendritic cell biology in HIV-1 infection stress key understudied areas in infection, pathogenesis, and analysis of viral reservoirs. J Leukoc Biol 80:961-964.
32. Nagai F, Hiyoshi Y, Sugimachi K, Tamura HO (2002) Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines. Biol Pharm Bull 25:383-385.
33. Nakajima M, Yamamoto T, Nunoya K, Yokoi T, Nagashima K, Inoue K, Funae Y, Shimada N, Kamataki T, Kuroiwa Y (1996) Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos 24:1212-1217.
34. Nebert DW, Dalton TP, Okey AB, Gonzalez FJ (2004) Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 279:23847-23850.
35. Niemela O, Parkkila S, Juvonen R, Viitala K, Gelboin HV, Pasanen M (2000) Cytochromes P450 2A6, 2El, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. J Hepatol 33:893-901.
36. Pal D, Mitra AK (2006) MDR- and CYP3A4-mediated drug-drug interactions. J Neuroimmune Pharmacol 1:323-339.
37. Perno CF, Newcomb FM, Davis DA, Aquaro S, Humphrey RW, Caliò R, Yarchoan R (1998) Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. J Infect Dis 178:413-422.
38. Raucy JL, Lasker J, Ozaki K, Zoleta V (2004) Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicol Sci 79:233-241.
39. Ronaldson PT, Persidsky Y, Bendayan R (2008) Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection. Glia 56:1711-1735.
40. Silverstein PS, Audus KL, Qureshi N, Kumar A (2009) Lipopolysaccharide increases the expression of Multidrug Resistance-Associated Protein 1 (MRP1) in RAW 264.7 macrophages. J Neuroimmune Pharmacol. DOI: .
41. Skazik C, Heise R, Bostanci O, Paul N, Denecke B, Joussen S, Kiehl K, Merk HF, Zwadlo-Klarwasser G, Baron JM (2008) Differential expression of influx and efflux transport proteins in human antigen presenting cells. Exp Dermatol 17:739-747.
42. Walubo A (2007) The role of cytochrome P450 in anti-retroviral drug interactions. Expert Opin Drug Metab Toxicol 3:583-598.
43. Zanger UM, Turpeinen M, Klein K, Schwab M (2008) Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Anal Bioanal Chem 392:1093-1108.