Protein kinase A-mediated phosphorylation of the RASSF1A tumour suppressor at Serine 203 and regulation of RASSF1A function

European Journal of Cancer

Volumn 46, Issue 16, 2010, Pages 2986-2995

  Richter, Antje M ^a   Schagdarsurengin, Undraga ^a   Rastetter, Matthias ^a,b   Steinmann, Katrin ^a   Dammann, Reinhard H ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b Berufsgenossenschaft Rohstoffe und Chemische Industrie   (Germany)

Author keywords

Apoptosis; Phosphorylation; PKA; RASSF1A; Tumour suppressor

Indexed keywords

ALANINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN BAX; PROTEIN P21; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SERINE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL DEATH; CODON; CONTROLLED STUDY; ENZYME INHIBITION; GENE CONTROL; GENE INDUCTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

AMINO ACID SUBSTITUTION; APOPTOSIS; CELL LINE, TUMOR; CODON; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EPIGENESIS, GENETIC; HUMANS; MICROTUBULES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; TUMOR SUPPRESSOR PROTEINS;

EID: 78049299530     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.06.128     Document Type: Article

References (36)

1. R. Dammann, C. Li, and J.H. Yoon Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3 Nat Genet 25 2000 315 319
2. D. Vavvas, X. Li, J. Avruch, and X.F. Zhang Identification of Nore1 as a potential Ras effector J Biol Chem 273 1998 5439 5442
3. C.P. Ponting, and D.R. Benjamin A novel family of Ras-binding domains Trends Biochem Sci 21 1996 422 425
4. Y. Sekido, M. Ahmadian, and I.I. Wistuba Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumour suppressor gene Oncogene 16 1998 3151 3157
5. M.I. Lerman, and J.D. Minna The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumour suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumour Suppressor Gene Consortium Cancer Res 60 2000 6116 6133
6. A.M. Richter, G.P. Pfeifer, and R.H. Dammann The RASSF proteins in cancer; from epigenetic silencing to functional characterization Biochim Biophys Acta 1796 2009 114 128
7. A.C. Newton Protein kinase C. Seeing two domains Curr Biol 5 1995 973 976
8. S.T. Kim, D.S. Lim, C.E. Canman, and M.B. Kastan Substrate specificities and identification of putative substrates of ATM kinase family members J Biol Chem 274 1999 37538 37543
9. G. Hamilton, K.S. Yee, S. Scrace, and E. O'Neill ATM regulates a RASSF1A-dependent DNA damage response Curr Biol 19 2009 2020 2025
10. H. Scheel, and K. Hofmann A novel interaction motif, SARAH, connects three classes of tumour suppressor Curr Biol 13 2003 R899 R900
11. N. Tapon, K.F. Harvey, and D.W. Bell Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines Cell 110 2002 467 478
12. S. Wu, J. Huang, J. Dong, and D. Pan Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts Cell 114 2003 445 456
13. K.F. Harvey, C.M. Pfleger, and I.K. Hariharan The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis Cell 114 2003 457 467
14. B.A. Hay, and M. Guo Coupling cell growth, proliferation, and death. Hippo weighs in Dev Cell 5 2003 361 363
15. M. Praskova, A. Khoklatchev, S. Ortiz-Vega, and J. Avruch Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras Biochem J 381 2004 453 462
16. R. Rong, L.Y. Jiang, M.S. Sheikh, and Y. Huang Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation Oncogene 26 2007 7700 7708
17. S.J. Song, M.S. Song, and S.J. Kim Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity Cancer Res 69 2009 2314 2323
18. L. Liu, C. Guo, R. Dammann, S. Tommasi, and G.P. Pfeifer RASSF1A interacts with and activates the mitotic kinase Aurora-A Oncogene 27 2008 6175 6186
19. S.J. Song, S.J. Kim, M.S. Song, and D.S. Lim Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody Cancer Res 69 2009 8540 8544
20. S.K. Verma, T.S. Ganesan, and P.J. Parker The tumour suppressor RASSF1A is a novel substrate of PKC FEBS Lett 582 2008 2270 2276
21. J.C. Obenauer, L.C. Cantley, and M.B. Yaffe Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs Nucleic Acids Res 31 2003 3635 3641
22. C. Lindon, and J. Pines Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells J Cell Biol 164 2004 233 241
23. B. Gao, X.J. Xie, and C. Huang RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers Cancer Res 68 2008 22 25
24. U. Schagdarsurengin, C. Seidel, and E.J. Ulbrich A polymorphism at codon 133 of the tumour suppressor RASSF1A is associated with tumourous alteration of the breast Int J Oncol 27 2005 185 191
25. 2+ dependent protein kinase Biochem Biophys Res Commun 135 1986 397 402
26. D. Matallanas, D. Romano, and K. Yee RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumour suppressor protein Mol Cell 27 2007 962 975
27. S.P. Collins, J.L. Reoma, D.M. Gamm, and M.D. Uhler LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo Biochem J 345 2000 673 680
28. I. The, G.E. Hannigan, and G.S. Cowley Rescue of a Drosophila NF1 mutant phenotype by protein kinase A Science 276 1997 791 794
29. K. Ye Phosphorylation of merlin regulates its stability and tumour suppressive activity Cell Adh Migr 1 2007 196 198
30. Y. Ye, B. Raychaudhuri, A. Gurney, C.E. Campbell, and B.R. Williams Regulation of WT1 by phosphorylation: inhibition of DNA binding, alteration of transcriptional activity and cellular translocation EMBO J 15 1996 5606 5615
31. L. Liu, S. Tommasi, D.H. Lee, R. Dammann, and G.P. Pfeifer Control of microtubule stability by the RASSF1A tumour suppressor Oncogene 22 2003 8125 8136
32. V. De Laurenzi, and G. Melino Evolution of functions within the p53/p63/p73 family Ann NY Acad Sci 926 2000 90 100
33. E.C. Thornborrow, and J.J. Manfredi One mechanism for cell type-specific regulation of the bax promoter by the tumour suppressor p53 is dictated by the p53 response element J Biol Chem 274 1999 33747 33756
34. S. Thaler, P.S. Hahnel, A. Schad, R. Dammann, and M. Schuler RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt Cancer Res 69 2009 1748 1757
35. J. Downward, and S. Basu YAP and p73: a complex affair Mol Cell 32 2008 749 750
36. Q. Zeng, and W. Hong The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals Cancer Cell 13 2008 188 192