An Arabidopsis splicing RNP variant STEP1 regulates telomere length homeostasis by restricting access of nuclease and telomerase

Molecules and Cells

Volumn 30, Issue 3, 2010, Pages 279-283

  Yoo, Hyun Hee ^a   Kwon, Chian ^b   Chung, In Kwon ^a  

^a Yonsei University   (South Korea)

^b Dankook University   (South Korea)

Author keywords

Arabidopsis; RBD; STEP1; telomerase; telomere

Indexed keywords

ARABIDOPSIS PROTEIN; NUCLEASE; PROTEIN STEP 1; REPETITIVE DNA; RNA BINDING PROTEIN; RNA DIRECTED DNA POLYMERASE; TELOMERASE; TELOMERE BINDING PROTEIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ARABIDOPSIS; ARTICLE; CHROMOSOMAL PARAMETERS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN VARIANT; SPLICING DEFECT; TELOMERE; TELOMERE LENGTH;

ARABIDOPSIS; ARABIDOPSIS PROTEINS; CHLOROPLAST PROTEINS; DEOXYRIBONUCLEASES; PLANT PROTEINS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN SPLICING; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOPROTEINS; TELOMERASE; TELOMERE;

ARABIDOPSIS; EUKARYOTA;

EID: 78049284253     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10059-010-0115-y     Document Type: Article

References (23)

1. P. Baumann T.R. Cech 2001 Pot1, the putative telomere end-binding protein in fission yeast and humans Science 292 1171 1175 1:CAS:528: DC%2BD3MXjs1Cguro%3D 10.1126/science.1060036 11349150 (Pubitemid 32440940)
2. A. Bianchi D. Shore 2008 How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex Mol. Cell 31 153 165 1:CAS:528:DC%2BD1cXpsFOgt7Y%3D 10.1016/j.molcel.2008.06.013 18657499 (Pubitemid 352005819)
3. S.H. Cheng K. Cline A.J. DeLisle 1994 An Arabidopsis chloroplast RNA-binding protein gene encodes multiple mRNAs with different 5′ ends Plant Physiol 106 303 311 1:CAS:528:DyaK2cXmt1emtro%3D 10.1104/pp.106.1.303 7972518
4. M.W. Djojosubroto Y.S. Choi H.-W. Lee K.L. Rudolph 2003 Telomeres and telomerase in aging, regeneration and cancer Mol. Cells 15 164 175 1:CAS:528:DC%2BD3sXkvVeqs7w%3D 12803478
5. S. Fiset B. Chabot 2001 hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro Nucleic Acids Res 29 2268 2275 1:CAS:528:DC%2BD3MXksVShur4%3D 10.1093/nar/29.11.2268 11376145
6. L.P. Ford W.E. Wright J.W. Shay 2002 A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation Oncogene 21 580 583 1:CAS:528:DC%2BD38Xht1Sntbk%3D 10.1038/sj.onc.1205086 11850782
7. C.W. Greider 1996 Telomere length regulation Annu. Rev. Biochem. 65 337 365 1:CAS:528:DyaK28XktFamtLY%3D 10.1146/annurev.bi.65.070196.002005 8811183
8. J.P. Hong M.Y. Byun D.H. Koo K. An J.W. Bang I.K. Chung G. An W.T. Kim 2007 Suppression of RICE TELOMERE BINDING PROTEIN 1 results in severe and gradual developmental defects accompanied by genome instability in rice Plant Cell 19 1770 1781 1:CAS:528:DC%2BD2sXptFKgu7c%3D 10.1105/tpc.107.051953 17586654 (Pubitemid 47218839)
9. K.S. Joeng E.J. Song K.J. Lee J. Lee 2004 Long lifespan in worms with long telomeric DNA Nat. Genet. 36 607 611 1:CAS:528:DC%2BD2cXksVajtrc%3D 10.1038/ng1356 15122256 (Pubitemid 38715988)
10. J.H. Kim J.H. Kim G.E. Lee J.E. Lee I.K. Chung 2003 Potent inhibition of human telomerase by nitrostyrene derivatives Mol. Pharmacol. 63 1117 1124 1:CAS:528:DC%2BD3sXjt12ksr4%3D 10.1124/mol.63.5.1117 12695540 (Pubitemid 36529930)
11. J.H. Kim S.-M. Park M.R. Kang S.-Y. Oh T.H. Lee M.T. Muller I.K. Chung 2005 Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT Genes Dev 19 776 781 1:CAS:528:DC%2BD2MXjt1OjtLo%3D 10.1101/gad.1289405 15805468
12. C. Kwon I.K. Chung 2004 Interaction of an Arabidopsis RNA-binding protein with plant single-stranded telomeric DNA modulates telomerase activity J. Biol. Chem. 279 12812 12818 1:CAS:528:DC%2BD2cXitl2gtLs%3D 10.1074/jbc.M312011200 14703514 (Pubitemid 38445854)
13. H. LaBranche S. Dupuis Y. Ben-David M.R. Bani R.J. Wellinger B. Chabot 1998 Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase Nat. Genet. 19 199 202 1:CAS:528: DyaK1cXls1Cqtb8%3D 10.1038/575 9620782 (Pubitemid 28253328)
14. J. Lingner J.P. Cooper T.R. Cech 1995 Telomerase and DNA end replication: no longer a lagging strand problem? Science 269 1533 1534 1:CAS:528: DyaK2MXotVOgsb8%3D 10.1126/science.7545310 7545310
15. M. Ohta M. Sugita M. Sugiura 1995 Three types of nuclear genes encoding chloroplast RNA-binding proteins (cp29, cp31 and cp33) are present in Arabidopsis thaliana: presence of cp31 in chloroplasts and its homologue in nuclei/cytoplasms Plant Mol. Biol. 27 529 539 1:CAS:528:DyaK2MXksVClsLk%3D 10.1007/BF00019319 7894017
16. D. Shore A. Bianchi 2009 Telomere length regulation: coupling DNA end processing to feedback regulation of telomerase EMBO J 28 2309 2322 1:CAS:528:DC%2BD1MXotlSntbw%3D 10.1038/emboj.2009.195 19629031
17. Y.V. Surovtseva E.V. Shakirov L. Vespa N. Osbun X. Song D.E. Shippen 2007 Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance EMBO J 26 3653 3661 1:CAS:528:DC%2BD2sXos1eqtbs%3D 10.1038/sj.emboj.7601792 17627276 (Pubitemid 47236877)
18. B. van Steensel T. de Lange 1997 Control of telomere length by the human telomeric protein TRF1 Nature 385 740 743 10.1038/385740a0 9034193 (Pubitemid 27098097)
19. B. van Steensel A. Smogorzewska T. de Lange 1998 TRF2 protects human telomeres from end-to-end fusions Cell 92 401 413 10.1016/S0092-8674(00)80932-0 9476899 (Pubitemid 28093017)
20. S.W. Yang D.H. Kim J.J. Lee Y.J. Chun J.H. Lee Y.J. Kim I.K. Chung W.T. Kim 2003 Expression of the telomeric repeat binding factor gene NgTRF1 is closely coordinated with the cell division program in tobacco BY-2 suspension culture cells J. Biol. Chem. 278 21395 21407 1:CAS:528:DC%2BD3sXksVenu70%3D 10.1074/jbc.M209973200 12646586 (Pubitemid 36792535)
21. S.W. Yang S.K. Kim W.T. Kim 2004 Perturbation of NgTRF1 expression induces apoptosis-like cell death in tobacco BY-2 cells and implicates NgTRF1 in the control of telomere length and stability Plant Cell 16 3370 3385 1:CAS:528:DC%2BD2MXhtVKksA%3D%3D 10.1105/tpc.104.026278 15528297 (Pubitemid 41096012)
22. H.H. Yoo C. Kwon M.M. Lee I.K. Chung 2007 Singlestranded DNA binding factor AtWHY1 modulates telomere length homeostasis in Arabidopsis Plant J 49 442 451 1:CAS:528:DC%2BD2sXisVyisbw%3D 10.1111/j.1365-313X.2006.02974.x 17217467 (Pubitemid 46146625)
23. E.Y. Yu S.E. Kim J.H. Kim J.H. Ko M.H. Cho I.K. Chung 2000 Sequence-specific DNA recognition by the Myb-like domain of plant telomeric protein RTBP1 J. Biol. Chem. 275 24208 24214 1:CAS:528:DC%2BD3cXls12ltrs%3D 10.1074/jbc.M003250200 10811811 (Pubitemid 30624711)