Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization

European Journal of Pharmacology

Volumn 649, Issue 1-3, 2010, Pages 29-37

  Lennon, Siân M ^a,b   Rivero, Guadalupe ^a   Matharu, Annelise ^a   Howson, Patrick A ^a   Jane, David E ^a   Roberts, Peter J ^a   Kelly, Eamonn ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

C6 glioma cell; CAMP accumulation; Chinese hamster ovary cells; Desensitization; MGlu2 receptor; Protein kinase C; Spinal cord

Indexed keywords

CYCLIC AMP; METABOTROPIC RECEPTOR 2; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHO CELL; CONTROLLED STUDY; DORSAL ROOT POTENTIAL; GLIOMA CELL; IN VITRO STUDY; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION;

ADENYLATE CYCLASE; AMINO ACIDS, DICARBOXYLIC; ANIMALS; ANIMALS, NEWBORN; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; ENZYME ACTIVATORS; EVOKED POTENTIALS; EXCITATORY AMINO ACID AGONISTS; NERVE TISSUE PROTEINS; NEURONS; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; SPINAL NERVE ROOTS;

EID: 78049280659     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.08.038     Document Type: Article

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