The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation

British Journal of Pharmacology

Volumn 148, Issue 3, 2006, Pages 279-290

  Mathiesen, Jesper Mosolff ^a,b,c   Ramirez, M Teresa ^a,d  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c 7TM Pharma A S   (Denmark)

^d Zealand Pharma AS   (Denmark)

Author keywords

cAMP; Chimeric G protein; Desensitization; Inositol phosphate; Internalization; mGluR4; PMA; Protein kinase C

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; ADENYLATE CYCLASE; ALPHA CYCLOPROPYL 4 PHOSPHONOPHENYLGLYCINE; CYCLIC AMP; FORSKOLIN; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; METABOTROPIC RECEPTOR 4; MYC PROTEIN; NEUROKININ 3 RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DESENSITIZATION; EMBRYO; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOLECULAR BIOLOGY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENYLATE CYCLASE; CELL LINE; ENDOCYTOSIS; ENZYME ACTIVATION; HUMANS; PHOSPHOLIPASE C; PROTEIN KINASE C; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; TRANSFECTION; TYPE C PHOSPHOLIPASES;

EID: 33744473559     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706733     Document Type: Article

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