Improving biocatalyst performance by integrating statistical methods into protein engineering

Applied and Environmental Microbiology

Volumn 76, Issue 19, 2010, Pages 6397-6403

  Brouk, Moran ^a   Nov, Yuval ^b   Fishman, A ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b UNIVERSITY OF HAIFA   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2-PHENYLETHANOL; DATA SETS; DIRECTED EVOLUTION; INITIAL OXIDATION; MINIMUM TIME; MONOOXYGENASES; NATURAL SUBSTRATES; POINT MUTATIONS; PRE-SELECTED; PROTEIN ENGINEERING; RATIONAL DESIGN; STATISTICAL ANALYSIS; STATISTICAL MODELS; TRIPLE MUTANTS; WILD TYPES;

BIOCHEMICAL ENGINEERING; ETHANOL; GENETIC ENGINEERING; STATISTICS; TOLUENE;

ENZYME ACTIVITY;

3,4-DIHYDROXYPHENYLETHANOL; DRUG DERIVATIVE; HYDROXYTYROSOL; MUTANT PROTEIN; OXYGENASE; PHENETHYL ALCOHOL; TOLUENE 4 MONOOXYGENASE; TOLUENE-4-MONOOXYGENASE;

CATALYST; DATA SET; ENZYME ACTIVITY; MUTATION; OXIDATION; PROTEIN; SUBSTRATE; TOLUENE;

ARTICLE; BIOSTATISTICS; DIRECTED MOLECULAR EVOLUTION; GENETICS; HYDROXYLATION; KINETICS; METABOLISM; METHODOLOGY; PROTEIN ENGINEERING;

BIOSTATISTICS; DIRECTED MOLECULAR EVOLUTION; HYDROXYLATION; KINETICS; MUTANT PROTEINS; OXYGENASES; PHENYLETHYL ALCOHOL; PROTEIN ENGINEERING;

EID: 78049263384     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00878-10     Document Type: Article

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