Preliminary evaluation of acute toxicity of 188Re-BMEDA-liposome in rats

Journal of Applied Toxicology

Volumn 30, Issue 7, 2010, Pages 680-687

  Liu, Chi Mou ^a   Chang, Chih Hsien ^a   Chang, Ya Jen ^a   Hsu, Chin Wei ^a   Chen, Liang Cheng ^a   Chen, Hsiao Lin ^b   Ho, Chung Li ^a   Yu, Chia Yu ^a   Chang, Tsui Jung ^a   Chiang, Tung Chuan ^a   Lee, Te Wei ^a  

^a INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

^b DEVELOPMENT CENTER FOR BIOTECHNOLOGY   (Taiwan)

Author keywords

188Re BMEDA liposome; Acute toxicity; Radiopharmaceutical; Radiotoxicology; Sprague Dawley rats

Indexed keywords

LIPOSOME; RHENIUM 188;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD ANALYSIS; BODY WEIGHT; CHEMICAL ANALYSIS; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DICENTRIC CHROMOSOME; DRUG SAFETY; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; LEUKOCYTE COUNT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; TOXICITY TESTING; WEIGHT REDUCTION;

ACUTE TOXICITY TESTS; ANIMALS; CHELATING AGENTS; DRUG EVALUATION, PRECLINICAL; ETHYLENEDIAMINES; FEMALE; INJECTIONS, INTRAVENOUS; LIPOSOMES; MALE; ORGANOMETALLIC COMPOUNDS; POLYETHYLENE GLYCOLS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RHENIUM;

ANIMALIA; RATTUS;

EID: 78049246343     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1541     Document Type: Article

References (36)

1. Allen TM, Cullis PR. 2004. Drug delivery systems: entering the mainstream. Science 303: 1818-1822.
2. 186Re-SNS/S complexes: in vitro stability, imaging, and biodistribution in rats. J. Nucl. Med. 44: 1992-1999.
3. Bartlett GR. 1959. Phosphorus assay in column chromatography. J. Biol. Chem. 234: 466-468.
4. Bauchinger M, Schmid E, Braselmann H. 1986. Cell survival and radiation induced chromosome aberrations. II. Experimental findings in human lymphocytes analysed in first and second post-irradiation metaphases. Radiat. Environ. Biophys. 25: 253-260.
5. Carrano AV. 1973. Chromosome aberrations and radiation-induced cell death. II. Predicted and observed cell survival. Mutat. Res. 17: 355-366.
6. Center for Drug Evaluation and Research. 1996. Single Dose and Repeat Dose Toxicity Tests. FDA.
7. 188Re-(DXR)-liposome for internal radiotherapy. Cancer Biother. Radiopharm. 23: 749-758.
8. Chang CH, Chiu SP, Chiang TC, Lee TW. Acute intravenous injection toxicity of BMEDA in mice. Drug Chem. Toxicol. (in press).
9. 188Re-BMEDA-liposome in a C26 murine colon carcinoma solid tumor animal model. Anticancer. Res. 27: 2217-2225.
10. 188Re-DXR-liposome in a C26 murine colon carcinoma solid tumor model. Nucl. Med. Biol. 37: 95-104.
11. 188Re-BMEDA-labeled pegylated liposomes after intraperitoneal injection in a C26 colon carcinoma ascites mouse model. Nucl. Med. Biol. 34: 415-423.
12. 188Re-DXR-liposome in C26 colon carcinoma ascites mice model. Nucl. Med. Biol. 35: 883-893.
13. 188Re-(DXR)-liposome in human colorectal adenocarcinoma-bearing mice. Anticancer Res. 30: 65-72.
14. 131I-lipiodol therapy in patients with hepatocellular carcinoma. J. Nucl. Med. 45: 612-618.
15. Emfietzoglou D, Kostarelos K, Sgouros G. 2001. An analytic dosimetry study for the use of radionuclide-liposome conjugates in internal radiotherapy. J. Nucl. Med. 42: 499-504.
16. Emfietzoglou D, Kostarelos K, Papakostas A, Yang WH, Ballangrud A, Song H, Sgouros G. 2005. Liposome-mediated radiotherapeutics within avascular tumor spheroids: comparative dosimetry study for various radionuclides, liposome systems, and a targeting antibody. J. Nucl. Med. 46: 89-97.
17. Gabizon A, Papahadjopoulos D. 1988. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl Acad. Sci. USA 85: 6949-6953.
18. 188Re incorporated in liposomes suitable for radiotherapy. Int. J. Radiat. Appl. Instrum. B 18: 449-454.
19. 99mTc]DTPA-mannosyl-dextran. Nucl. Med. Biol. 30: 457-464.
20. 11C]methyl-l-tyrosine for tumor imaging by positron emission tomography. Nucl. Med. Biol. 32: 253-262.
21. 188Re-direct labeling of monoclonal antibodies for radioimmunotherapy of solid tumors: biodistribution, normal organ dosimetry, and toxicology. Nucl. Med. Biol. 25: 441-447.
22. 177Lu-labeled monoclonal antibody MN-14 to carcinoembryonic antigen in mice with small peritoneal metastases of colorectal origin. J. Nucl. Med. 45: 1224-1232.
23. Kostarelos K, Emfietzoglou D. 2000. Tissue dosimetry of liposome-radionuclide complexes for internal radiotherapy: toward liposome-targeted therapeutic radiopharmaceuticals. Anticancer Res. 20: 3339-3345.
24. Kostyniak PJ, Brenner JS, Maccubbin AE, Nakeeb S, Kasliwal R, Kung HF. 1988. The toxicity and mutagenicity of S-3-iodo-N-(1-ethyl-2-pyrrolidinyl)methyl-2-hydroxy-6-methoxybenzamide (IBZM), a new CNS D-2 dopamine receptor imaging agent. Drug Chem. Toxicol. 11: 433-442.
25. Lillie LE, Temple NJ, Florence LZ. 1996. Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry. Hum. Exp. Toxicol. 15: 612-616.
26. Liu Q, Nobaek S, Adawi D, Mao Y, Wang M, Molin G, Ekelund M, Jeppsson B. 2001. Administration of Lactobacillus plantarum 299v reduces side-effects of external radiation on colon anastomotic healing in an experimental model. Colorectal Dis. 3: 245-252.
27. Marzin D. 1998. Preclinical evaluation of radiopharmaceutical toxicological prerequisites. Nucl. Med. Biol. 25: 733-736.
28. McQuarrie S, Mercer J, Syme A, Suresh M, Miller G. 2005. Preliminary results of nanopharmaceuticals used in the radioimmunotherapy of ovarian cancer. J. Pharm. Pharm. Sci. 7: 29-34.
29. Petterino C, Argentino-Storino A. 2006. Clinical chemistry and haematology historical data in control Sprague-Dawley rats from pre-clinical toxicity studies. Exp. Toxicol. Pathol. 57: 213-219.
30. 111In-DTPA-human epidermal growth factor: an auger electron-emitting radiotherapeutic agent for epidermal growth factor receptor-positive breast cancer. J. Nucl. Med. 47: 1023-1031.
31. Spruill MD, Ramsey MJ, Swiger RR, Nath J, Tucker JD. 1996. The persistence of aberrations in mice induced by gamma radiation as measured by chromosome painting. Mutat. Res. 356: 135-145.
32. Torchilin VP. 2005. Recent advances with liposomes as pharmaceutical carriers. Nat. Rev. Drug Discov. 4: 145-160.
33. Tucker JD, Breneman JW, Briner JF, Eveleth GG, Langlois RG, Moore DH, 2nd. 1997. Persistence of radiation-induced translocations in rat peripheral blood determined by chromosome painting. Environ. Mol. Mutagen. 30: 264-272.
34. 18F]FPS. Nucl. Med. Biol. 30: 555-563.
35. Yang AS, Chiang TC, Hsu FF, Liao MH, Shen LH. 2008. Acute intravenous injection toxicity study of IBZM and BZM in rats. Drug Chem. Toxicol. 31: 529-533.
36. 186Re-liposome therapy in ovarian cancer xenograft model of peritoneal carcinomatosis. J. Drug Target. 16: 626-637.