An analytic dosimetry study for the use of radionuclide - Liposome conjugates in internal radiotherapy

Journal of Nuclear Medicine

Volumn 42, Issue 3, 2001, Pages 499-504

  Emfietzoglou, D ^a   Kostarelos, K ^a   Sgouros, G ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Dosimetry; Internal radiotherapy; Liposomes

Indexed keywords

2,3 BUTANEDIONE; CHOLESTEROL; COPPER 67; DISTEAROYLPHOSPHATIDYLCHOLINE; LIPOSOME; MONOSIALOGANGLIOSIDE; PHOSPHATE; RADIOISOTOPE; RHENIUM 188; YTTRIUM 90;

ARTICLE; BONE MARROW; CANCER RADIOTHERAPY; DOSIMETRY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG TARGETING; PRIORITY JOURNAL; RADIATION DOSE; RADIATION ENERGY; TISSUE DISTRIBUTION; TUMOR MODEL;

ANIMALS; BRACHYTHERAPY; COPPER RADIOISOTOPES; DRUG CARRIERS; IODINE RADIOISOTOPES; LIPOSOMES; MICE; NEOPLASMS; PARTICLE SIZE; RADIATION DOSAGE; RADIOISOTOPES; RHENIUM; TISSUE DISTRIBUTION; YTTRIUM RADIOISOTOPES;

EID: 0035093171     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Experimental approaches to increase radiolabeled antibody localization in tumors
2. 111In-DTPA-folate as a potential folate-receptor-targeted radiopharmaceutical
3. Blood-pool imaging using technetium-99m labeled liposomes
4. Fate and behavior of liposomes in vivo: A review of controlling factors
5. The effects of charge and size on the interaction of unilamellar liposomes with macrophages
6. The effect of poloxamer-407 on liposome stability and targeting to bone marrow: Comparison with polystyrene microspheres
7. Influence of cholesterol on the association of plasma proteins with liposomes
8. Large unilamellar liposomes with low uptake into the reticuloendothelial system
9. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors
10. Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM-containing liposomes
11. Extravasation and transcytosis of liposomes in Kaposi's sarcoma-like dermal lesions of transgenic mice bearing the HIV tat gene
12. Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumor tissue
13. Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft
14. Distinction between the depletion of opsonins and the saturation of uptake in the dose-dependent hepatic uptake of liposomes
15. Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ
16. In-III-labeled liposomes: Dosimetry and tumor depiction
17. 67Gallium-labeled liposomes with prolonged circulation: Preparation and potential as nuclear imaging agents
18. 188Re incorporated in liposomes suitable for radiotherapy
19. Uptake of yttrium-90 into lipid vesicles
20. 67Ga-carrying liposomes
21. Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma
22. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors
23. Recent achievements in the development of radiolabeled monoclonal antibodies for diagnosis, therapy and biologic characterization of human tumors
24. MIRDOSE: Personal computer software for internal dose assessment in nuclear medicine
25. Dosimetry of solid tumors
26. MIRD pamphlet no. 3: Absorbed fractions for photon dosimetry
27. MIRD pamphlet no. 8: Absorbed Fractions for small volumes containing photon-emitting radioactivity
28. Calculating dose from remaining body activity: A comparison of two methods
29. Bone marrow dosimetry for radioimmunotherapy: Theoretical considerations
30. Comparison of the effectiveness of some common animal data scaling techniques in estimating human radiation dose
31. Inhomogeneous deposition of radiopharmaceuticals at the cellular level: Experimental evidence and dosimetric implications
32. Successful imaging of human cancer with radiolabeled phospholipid vesicles (liposomes)
33. Biodistribution and pharmacokinetics of stealth liposomes in patients with solid tumors
34. Sterically stabilized liposomes labeled with rain to image focal infection in rats
35. Hematologic toxicity in radioimmunotherapy: An evaluation of different predictive measures
36. 99mTc]DTPA-folate and its evaluation as a folate-receptor-targeted radiopharmaceutical