Acute intravenous injection toxicity study of IBZM and BZM in rats

Drug and Chemical Toxicology

Volumn 31, Issue 4, 2008, Pages 529-533

  Yang, An Shoei ^a   Chiang, Tung Chuan ^a   Hsu, Fu Fa ^a   Liao, Mei Hsiu ^a   Shen, Lie Hang ^a  

^a INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

Author keywords

123I IBZM; Benzamide; CNS D2 dopamine receptor

Indexed keywords

N (1 ETHYL 2 PYRROLIDINYL)METHYL 2 HYDROXY 6 METHOXYBENZAMIDE; N [(1 ETHYL 2 PYRROLIDINYL)METHYL] 3 IODO 6 METHOXYSALICYLAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DOPAMINE RELEASE; FEMALE; MALE; MORTALITY; NEUROTOXICITY; NONHUMAN; NUCLEAR MEDICINE; RAT; SEX DIFFERENCE; WEIGHT GAIN;

ACUTE TOXICITY TESTS; ANIMALS; BENZAMIDES; BODY WEIGHT; CONTRAST MEDIA; DOPAMINE ANTAGONISTS; FEMALE; INJECTIONS, INTRAVENOUS; MALE; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 53849087131     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540802393332     Document Type: Article

References (8)

1. Derelanko, M. J. and Hollinger, M. A. (2001). CRC Handbook of Toxicology. CRC Press, USA.
2. DOH (2000). Guidelines for the Nonclinical Pharmacology/Toxicology Studies for Medicinal Products Applications, 3rd ed., Taiwan, ROC.
3. FDA (1996). Single Dose Acute Toxicity Testing for Pharmaceuticals, USA.
4. JMHW (1993). Guidelines for Toxicity Studies of Drugs, Japan.
5. Kung H. F., Guo Z., Billings J., Xu X., Mach R. H., Blau M. and Ackerhalt R. E. (1988). Preparation and biodistribution of [123I]IBZM: A potential CNS D-2 dopamine receptor imaging agent. Nucl. Med. Biol. 15: 195-201.
6. Bobeldijk M., Verhoeff N. P. L. G., Vekemans J. A. J. M., Buck H. M., van Doremalan P. A. P. M., van Hoof J. J. and Janssen A. G. M. (1990). A simple and high-yield synthesis of (S)-BZM, (R)-BZM and (S)-IBZM for the preparation of (S)123I-IBZM. J. Lab. Comp. Radiopharm. 28:1247-1256.
7. Ronald M. B., Xing Fu, Nora S. Kula, Ross J. B., Louis A., Robert B. I. and Gilles D. T. (2003). Synthesis and Affinity of a Possible Byproduct of Electrophilic Radiolabeling of [123I]IBZM. Bio. Med. Chem. Let. 13: 4015-4017.
8. Kostyniak P. J., Brenner J. S., Maccubbin A. E., Nakeeb S., Kasliwal R. and Kung H. F. (1988). The toxicity and mutagenicity of S-3-iodo-N-(1-ethyl-2- pyrrolidinyl) methyl-2-hydroxy-6-methoxybenzamide (IBZM), a new CNS D-2 dopamine receptor imaging agent. Drug Chem. Toxicol. 11(4): 433-42.