Tissue dosimetry of liposome-radionuclide complexes for internal radiotherapy: Toward liposome-targeted therapeutic radiopharmaceuticals

Anticancer Research

Volumn 20, Issue 5, 2000, Pages 3339-3345

  Kostarelos, K ^a   Emfietzoglou, D ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Dosimetry; Liposome; Radionuclide; Radiopharmaceuticals; Radiotherapy; Tumor targeting

Indexed keywords

ASTATINE 211; COPPER 67; GANGLIOSIDE GM1; IODINE 131; LIPOSOME; MACROGOL; RADIOPHARMACEUTICAL AGENT; RHENIUM 188; YTTRIUM 90;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSIMETRY; DRUG ACCUMULATION; DRUG HALF LIFE; DRUG TARGETING; DRUG TUMOR LEVEL; KIDNEY; LIVER; LIVER TUMOR; MICROENCAPSULATION; MOUSE; MUSCLE TUMOR; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOTHERAPY; RADIOISOTOPE DISTRIBUTION; SPLEEN;

ANIMALS; ASTATINE; COPPER RADIOISOTOPES; HUMANS; IODINE RADIOISOTOPES; LIPOSOMES; LIVER NEOPLASMS; MICE; MUSCLE NEOPLASMS; RADIOPHARMACEUTICALS; RHENIUM; YTTRIUM RADIOISOTOPES;

EID: 0033794087     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Imaging experimental osteomyelitis using radiolabeled liposomes
2. Dual radiolabeled liposomes: Biodistribution studies and localization of focal sites in rats
3. Liposomes for scintigraphic detection of infection and inflamation
4. Development of a liposome-encapsulated radionuclide with preferential tumor accumulation-the choice of radionuclide and chelating ligand
5. An improved method for in vivo tracing and imaging of liposomes using a gallium-67- deferoxamine complex
6. A simple method for producing a technetium-99m-labeled liposome which is stable in vivo
7. Labeling of preformed liposomes with Ga-67 and Tc-99m by chelation
8. Liposomes prepared from synthetic amphiphiles. I. Their technetium labeling and stability
9. Attachment of 99mTc to lipid vesicles containing the lipophilic chelate dipalmitoylphosphatidylethanolamine-DTPA
10. A novel method to label liposomes with 99mTc by the hydrazino nicotinyl derivative
11. In-111-labeled liposomes: Dosimetry and tumor depiction
12. Indium-111-labelled liposomes: Dosimetry and tumor detection in patients with cancer
13. Application of boronated anti-cea immunoliposomes to tumor-cell growth inhibition in in vitro boron neutron capture therapy model
14. Liposomes as drug delivery vehicles for boron agents
15. A lipophilic complex with 186Re/188Re incorporated in liposomes suitable for radiotherapy
16. Uptake of yttrium-90 into lipid vesicles
17. 67Ga-carrying liposomes
18. Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma
19. Application of the linear-quadratic model to radioimmunotherapy: Further support for the advantage of longer-lived radionuclides
20. Selection of radionuclides for radioimmunotherapy
21. Radioimmunotherapy with alpha-emitting nuclides
22. Absorbed fractions for small volumes containing photon-emitting radioactivity
23. Similarity principles and intrinsic geometries: Contrasting approaches to interspecies scaling
24. Comparison of the effectiveness of some common animal data scaling techniques in estimating human radiation dose
25. Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates
26. Treatment planning for internal emitter therapy: Methods, applications and clinical implications
27. Different intrahepatic distribution of phosphatidylglycerol and phosphatidylserine liposomes in the rat
28. 125I-Labeled Monoclonal Antibody 17-1A in Mice Bearing xenografts of Human Pancreatic Carcinoma Hup-T4
29. Dosimetry of solid tumors
30. Liposomal muramyl tripeptide phosphatidylethanolamine (MTP- PE) promotes haemopoietic recovery in irradiated mouse
31. Stimulation of haematopoiesis and protection of mice against radiation injury by synthetic analogues of muramyldipeptide incorporated in liposomes
32. Delivery of molecular and cellular medicine to solid tumors
33. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
34. Increased liposome extravasation in selected tissues - Effect of substance P
35. A new temperature-sensitive liposome for use with mild hyperthermia: Characterization and testing in a human tumor xenograft model
36. Suppression of liver uptake of liposome by dextran sulfate
37. Liposomal blockade of the reticuloendothelial system: Improved tumor imaging with small unilamellar vesicles
38. Active removal of radioactivity in the blood circulation using biotin-bearing liposomes and avidin for rapid tumor imaging
39. Rapid tumor imaging by active background reduction using biotin-bearing liposomes and avidin
40. Improved delivery of radiolabeled anti-B1 monoclonal antibody to Raji lymphoma xenografts by predosing with unlabeled anti-B1 monoclonal antibody
41. Experimental approaches to increase radiolabeled antibody localization in tumors
42. Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: The lack of beneficial effects by coating liposomes with poly(ethylene glycol)
43. Liposome longevity and stability in circulation: Effects on the in vivo delivery to tumors and therapeutic efficacy of encapsulated anthracyclines