Inhibitory signaling of 17β-estradiol in platelet activation: The pivotal role of cyclic AMP-mediated nitric oxide synthase activation

European Journal of Pharmacology

Volumn 649, Issue 1-3, 2010, Pages 140-149

  Wu, Gong Jhe ^a,b   Lee, Jie Jen ^c   Chou, Duen Suey ^b   Jayakumar, Thanasekaran ^b   Hsiao, George ^b   Chen, Wei Fan ^b   Sheu, Joen Rong ^b  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

17 Estradiol; Cyclic AMP; Nitric oxide synthase; Phospholipase C 2; Platelet activation

Indexed keywords

CALCIUM ION; COLLAGEN; CYCLIC AMP; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTRADIOL; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE C; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ADULT; ARTICLE; CELL STIMULATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; MALE; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION;

ADENYLATE CYCLASE; ADULT; CARDIOVASCULAR DISEASES; COLLAGEN; CYCLIC AMP; ENZYME ACTIVATION; ENZYME INHIBITORS; ESTRADIOL; ESTRADIOL ANTAGONISTS; FEMALE; HUMANS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OSMOLAR CONCENTRATION; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 78049246328     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.09.055     Document Type: Article

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