Decrease of mitochondrial DNA level in sperm from patients infected with human immunodeficiency virus-1 linked to nucleoside analogue reverse transcriptase inhibitors

Fertility and Sterility

Volumn 94, Issue 6, 2010, Pages 2151-2156

  Pavili, Lynda ^a   Daudin, Myriam ^a   Moinard, Nathalie ^a   Walschaerts, Marie ^a   Cuzin, Lise ^b   Massip, Patrice ^b   Pasquier, Christophe ^b   Bujan, Louis ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b CHU PURPAN   (France)

Author keywords

antiretroviral treatment; HIV; mitochondrial DNA; nucleoside analogue reverse transcriptase inhibitors; side effects; sperm parameters; spermatozoa

Indexed keywords

BETA GLOBIN; DIDANOSINE; MITOCHONDRIAL DNA; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; ZALCITABINE; ZIDOVUDINE;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; DENSITY GRADIENT CENTRIFUGATION; DNA DETERMINATION; DNA EXTRACTION; GENE AMPLIFICATION; GENE EXPRESSION; GENE LOCATION; GENE NUMBER; GENE SEQUENCE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED LIPODYSTROPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MALE; MITOCHONDRIAL TOXICITY; MIXED INFECTION; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SEMEN ANALYSIS; SPERMATOZOON; SPERMATOZOON COUNT; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; TEACHING HOSPITAL; UNIVERSITY HOSPITAL; VIRUS LOAD;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CASE-CONTROL STUDIES; DNA, MITOCHONDRIAL; DOWN-REGULATION; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS; SPERMATOZOA;

EID: 78049244400     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.12.080     Document Type: Article

References (41)

1. L. Bujan, L. Hollander, M. Coudert, C. Gilling-Smith, A. Vucetich, and J. Guibert Safety and efficacy of sperm washing in HIV-1-serodiscordant couples where the male is infected: results from the European CREAThE network AIDS 21 2007 1909 1914
2. J.N. Krieger, R.W. Coombs, A.C. Collier, J.K. Koehler, S.O. Ross, and K. Chaloupka Fertility parameters in men infected with human immunodeficiency virus J Infect Dis 164 1991 464 469
3. J.A. Crittenden, D.J. Handelsman, and G.J. Stewart Semen analysis in human immunodeficiency virus infection Fertil Steril 57 1992 1294 1299
4. F. Dondero, T. Rossi, G. D'Offizi, F. Mazzilli, R. Rosso, and N. Sarandrea Semen analysis in HIV seropositive men and in subjects at high risk for HIV infection Hum Reprod 11 1996 765 768
5. E. Dulioust, A.L. Du, D. Costagliola, J. Guibert, J.M. Kunstmann, and I. Heard Semen alterations in HIV-1 infected men Hum Reprod 17 2002 2112 2118
6. C.H. Muller, R.W. Coombs, and J.N. Krieger Effects of clinical stage and immunological status on semen analysis results in human immunodeficiency virus type 1-seropositive men Andrologia 30 Suppl 1 1998 15 22
7. J.D. Nicopoullos, P.A. Almeida, J.W. Ramsay, and C. Gilling-Smith The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing Hum Reprod 19 2004 2289 2297
8. L. Bujan, M. Sergerie, N. Moinard, S. Martinet, L. Porte, and P. Massip Decreased semen volume and spermatozoa motility in HIV-1-infected patients under antiretroviral treatment J Androl 28 2007 444 452
9. E. van Leeuwen, F.W. Wit, S. Repping, J.K. Eeftinck Schattenkerk, P. Reiss, and F. van der Veen Effects of antiretroviral therapy on semen quality AIDS 22 2008 637 642 (Pubitemid 351640596)
10. G.J. Moyle, and M. Sadler Peripheral neuropathy with nucleoside antiretrovirals: risk factors, incidence and management Drug Saf 19 1998 481 494
11. U.A. Walker, and K. Brinkman NRTI induced mitochondrial toxicity as a mechanism for HAART related lipodystrophy: fact or fiction? HIV Med 2 2001 163 165
12. M.C. Dalakas, I. Illa, G.H. Pezeshkpour, J.P. Laukaitis, B. Cohen, and J.L. Griffin Mitochondrial myopathy caused by long-term zidovudine therapy N Engl J Med 322 1990 1098 1105 (Pubitemid 20149526)
13. K. Brinkman, H.J. ter Hofstede, D.M. Burger, J.A. Smeitink, and P.P. Koopmans Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway AIDS 12 1998 1735 1744
14. G. Moyle Mechanisms of HIV and nucleoside reverse transcriptase inhibitor injury to mitochondria Antivir Ther 10 Suppl 2 2005 M47 M52
15. D. Nolan, E. Hammond, A. Martin, L. Taylor, S. Herrmann, and E. McKinnon Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy AIDS 17 2003 1329 1338
16. C.M. Shikuma, N. Hu, C. Milne, F. Yost, C. Waslien, and S. Shimizu Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy AIDS 15 2001 1801 1809
17. U.A. Walker, B. Setzer, and N. Venhoff Increased long-term mitochondrial toxicity in combinations of nucleoside analogue reverse-transcriptase inhibitors AIDS 16 2002 2165 2173
18. D. Hoschele Cell culture models for the investigation of NRTI-induced mitochondrial toxicity. Relevance for the prediction of clinical toxicity Toxicol In Vitro 20 2006 535 546
19. C.L. Cherry, D. Nolan, I.R. James, E.J. McKinnon, S.A. Mallal, and M.E. Gahan Tissue-specific associations between mitochondrial DNA levels and current treatment status in HIV-infected individuals J Acquir Immune Defic Syndr 42 2006 435 440
20. J.F. Hoy, M.E. Gahan, A. Carr, D. Smith, S.R. Lewin, and S. Wesselingh Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir J Infect Dis 190 2004 688 692
21. E.T. Donnelly, M. O'Connell, N. McClure, and S.E. Lewis Differences in nuclear DNA fragmentation and mitochondrial integrity of semen and prepared human spermatozoa Hum Reprod 15 2000 1552 1561
22. T. Folgero, K. Bertheussen, S. Lindal, T. Torbergsen, and P. Oian Mitochondrial disease and reduced sperm motility Hum Reprod 8 1993 1863 1868
23. S.H. Kao, H.T. Chao, and Y.H. Wei Multiple deletions of mitochondrial DNA are associated with the decline of motility and fertility of human spermatozoa Mol Hum Reprod 4 1998 657 666
24. P. May-Panloup, M.F. Chretien, F. Savagner, C. Vasseur, M. Jean, and Y. Malthiery Increased sperm mitochondrial DNA content in male infertility Hum Reprod 18 2003 550 556
25. E. Ruiz-Pesini, C. Diez, A.C. Lapena, A. Perez-Martos, J. Montoya, and E. Alvarez Correlation of sperm motility with mitochondrial enzymatic activities Clin Chem 44 1998 1616 1620
26. D.J. White, D. Mital, S. Taylor, and J.C. St John Sperm mitochondrial DNA deletions as a consequence of long term highly active antiretroviral therapy AIDS 15 2001 1061 1062
27. S. Diehl, P. Vernazza, A. Trein, E. Schnaitmann, B. Grimbacher, and B. Setzer Mitochondrial DNA and sperm quality in patients under antiretroviral therapy AIDS 17 2003 450 451
28. G.B. La Sala, E. Pilotti, A. Nicoli, S. Pinelli, M.T. Villani, and P. Ronzi Dynamics of HIV viral load in blood and semen of patients under HAART: impact of therapy in assisted reproduction procedures AIDS 21 2007 377 379
29. R. Leandri, E. Dulioust, E. Benbrik, P. Jouannet, and M. De Almeida Deficit in cytochrome c oxidase activity induced in rat sperm mitochondria by in vivo exposure to zidovudine Intern J Androl 26 2003 305 309
30. C. de Mendoza, M. Sanchez-Conde, E. Ribera, P. Domingo, and V. Soriano Could mitochondrial DNA quantitation be a surrogate marker for drug mitochondrial toxicity? AIDS Rev 6 2004 169 180
31. H.C. Cote, Z.L. Brumme, K.J. Craib, C.S. Alexander, B. Wynhoven, and L. Ting Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients N Engl J Med 346 2002 811 820
32. F. Chiappini, E. Teicher, R. Saffroy, P. Pham, B. Falissard, and A. Barrier Prospective evaluation of blood concentration of mitochondrial DNA as a marker of toxicity in 157 consecutively recruited untreated or HAART-treated HIV-positive patients Lab Invest 84 2004 908 914
33. D. Mital, D.J. White, and J.C. St John Mitochondrial DNA and sperm quality in patients on antiretroviral therapy - response AIDS 18 2004 963
34. World Health Organization (WHO) WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction 4th ed. 1999 Cambridge University Press Cambridge
35. J.P. Dadoune, M.J. Mayaux, and M.L. Guihard-Moscato Correlation between defects in chromatin condensation of human spermatozoa stained by aniline blue and semen characteristics Andrologia 20 1988 211 217
36. C. Pasquier, C. Souyris, N. Moinard, L. Bujan, and J. Izopet Validation of an automated real-time PCR protocol for detection and quantitation of HIV and HCV genomes in semen J Virol Methods 137 2006 156 159
37. M. Hayakawa, T. Ogawa, S. Sugiyama, M. Tanaka, and T. Ozawa Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine Biochem Biophys Res Commun 176 1991 87 93
38. J. Cummins Mitochondrial DNA in mammalian reproduction Rev Reprod 3 1998 172 182
39. P. Reynier, M.F. Chretien, F. Savagner, G. Larcher, V. Rohmer, and P. Barriere Long PCR analysis of human gamete mtDNA suggests defective mitochondrial maintenance in spermatozoa and supports the bottleneck theory for oocytes Biochem Biophys Res Commun 252 1998 373 377
40. J.C. St John, R.P. Jokhi, and C.L. Barratt Men with oligoasthenoteratozoospermia harbour higher numbers of multiple mitochondrial DNA deletions in their spermatozoa, but individual deletions are not indicative of overall aetiology Mol Hum Reprod 7 2001 103 111
41. P. Vernazza HAART improves quality of life: should we care about the quality of spermatozoa? AIDS 22 2008 647 648