Effects of antiretroviral therapy on semen quality

AIDS

Volumn 22, Issue 5, 2008, Pages 637-642

  Van Leeuwen, Elisabeth ^a   Wit, Ferdinand W ^a   Repping, Sjoerd ^a   Eeftinck Schattenkerk, Jan Karel M ^a   Reiss, Peter ^a   Van Der Veen, Fulco ^a   Prins, Jan M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Antiretroviral therapy; HIV 1; Longitudinal; Reproduction; Semen quality

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; EFAVIRENZ; LAMIVUDINE; LOPINAVIR; NEVIRAPINE; RITONAVIR; TENOFOVIR; THYMIDINE DERIVATIVE; ZIDOVUDINE;

ARTICLE; BLOOD; CLINICAL ARTICLE; DIARRHEA; DRUG SUBSTITUTION; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MALE; MOTILE SPERMATOZOA; NETHERLANDS; PRIORITY JOURNAL; SEMEN ABNORMALITY; SPERM; SPERMATOZOON;

ADULT; ANTI-RETROVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DRUG COMBINATIONS; FOLLICLE STIMULATING HORMONE; HIV INFECTIONS; HIV-1; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RNA, VIRAL; SEMEN; SPERM MOTILITY; SPERMATOZOA;

EID: 43149121793     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAD.0b013e3282f4de10     Document Type: Article

References (24)

1. Yeni PG, Hammer SM, Carpenter CC, Cooper DA, Fischl MA, Gatell JM, et al. Antiretroviral treatment for adult HIV infection in 2002: updated recommendations of the International AIDS Society - USA Panel. JAMA 2002; 288:222-235.
2. Brinkman K, ter Hofstede HJ, Burger DM, Smeitink JA, Koopmans PP. Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway. AIDS 1998; 12:1735-1744.
3. Carr A, Samaras K, Burton S, Law M, Freund J, Chisholm DJ, et al. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS 1998; 12:F51-F58.
4. Van der Valk M, Bisschop PH, Romijn JA, Ackermans MT, Lange JM, Endert E, et al. Lipodystrophy in HIV-1-positive patients is associated with insulin resistance in multiple metabolic pathways. AIDS 2001; 15:2093-2100.
5. Deeks SG. Antiretroviral treatment of HIV infected adults. BMJ 2006; 332:1489.
6. Lowe SH, Sankatsing SU, Repping S, Van de Veen F, Reiss P, Lange JM, et al. Is the male genital tract really a sanctuary site for HIV? Arguments that it is not. AIDS 2004; 18:1353-1362.
7. Hunault CC, Habbema JD, Eijkemans MJ, Collins JA, Evers JL, te Velde ER. Two new prediction rules for spontaneous pregnancy leading to live birth among subfertile couples, based on the synthesis of three previous models. Hum Reprod 2004; 19: 2019-2026.
8. Van der Steeg JW, Steures P, Eijkemans MJ, Habbema JD, Hompes PG, Broekmans FJ, et al. Pregnancy is predictable: a large-scale prospective external validation of the prediction of spontaneous pregnancy in subfertile couples. Hum Reprod 2007; 22:536-542.
9. World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction, 4th edn. Cambridge, UK: The press syndicate of Cambridge University Press; 1999.
10. Crittenden JA, Handelsman DJ, Stewart GJ. Semen analysis in human immunodeficiency virus infection. Fertil Steril 1992; 57:1294-1299.
11. Robbins WA, Witt KL, Haseman JK, Dunson DB, Troiani L, Cohen MS, et al. Antiretroviral therapy effects on genetic and morphologic end points in lymphocytes and sperm of men with human immunodeficiency virus infection. J Infect Dis 2001; 184:127-135.
12. Auger J, Eustache F, Ducot B, Blandin T, Daudin M, Diaz I, et al. Intra- and inter-individual variability in human sperm concentration, motility and vitality assessment during a workshop involving ten laboratories. Hum Reprod 2000; 15: 2360-2368.
13. Van Leeuwen E, Wit FW, Prins JM, Reiss P, Van der Veen F, Repping S. Semen quality remains stable during 96 weeks of untreated HIV-1 infection. Fertil Steril 2007; In press.
14. Evenson DP, Darzynkiewicz Z, Melamed MR. Simultaneous measurement by flow cytometry of sperm cell viability and mitochondrial membrane potential related to cell motility. J Histochem Cytochem 1982; 30:279-280.
15. Graham JK, Kunze E, Hammerstedt RH. Analysis of sperm cell viability, acrosomal integrity, and mitochondrial function using flow cytometry. Biol Reprod 1990; 43:55-64.
16. Brinkman K, Smeitink JA, Romijn JA, Reiss P. Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviraltherapy-related lipodystrophy. Lancet 1999; 354:1112-1115.
17. Van der Valk M, Casula M, Weverlingz GJ, van Kuijk K, Eck-Smit B, Hulsebosch HJ, et al. Prevalence of lipoatrophy and mitochondrial DNA content of blood and subcutaneous fat in HIV-1-infected patients randomly allocated to zidovudine-or stavudine-based therapy. Antivir Ther 2004; 9:385-393.
18. Casula M, Weverling GJ, Wit FW, Timmermans EC, Stek M Jr, Lange JM, et al. Mitochondrial DNA and RNA increase in peripheral blood mononuclear cells from HIV-1-infected patients randomized to receive stavudine-containing or stavudine-sparing combination therapy. J Infect Dis 2005; 192:1794-1800.
19. Diehl S, Vernazza P, Trein A, Schnaitmann E, Grimbacher B, Setzer B, et al. Mitochondrial DNA and sperm quality in patients under antiretroviral therapy. AIDS 2003; 17:450-451.
20. Sloand EM, Kumar PN, Kim S, Chaudhuri A, Weichold FF, Young NS. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood 1999; 94:1021-1027.
21. Weichold FF, Bryant JL, Pati S, Barabitskaya O, Gallo RC, Reitz MS Jr. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol 1999; 2:261-269.
22. Phenix BN, Angel JB, Mandy F, Kravcik S, Parato K, Chambers KA, et al. Decreased HIV-associated T cell apoptosis by HIV protease inhibitors. AIDS Res Hum Retroviruses 2000; 16:559-567.
23. Cossarizza A, Moyle G. Antiretroviral nucleoside and nucleotide analogues and mitochondria. AIDS 2004; 18:137-151.
24. Gerschenson M, Brinkman K. Mitochondrial dysfunction in AIDS and its treatment. Mitochondrion 2004; 4:763-777.