Men with oligoasthenoteratozoospermia harbour higher numbers of multiple mitochondrial DNA deletions in their spermatozoa, but individual deletions are not indicative of overall aetiology

Molecular Human Reproduction

Volumn 7, Issue 1, 2001, Pages 103-111

  St John, J C ^a   Jokhi, R P ^b   Barratt, C L R ^a  

^a BIRMINGHAM WOMEN S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Electron transfer chain; Long PCR; Mitochondrial DNA deletions; Reactive oxygen species; Spermatozoa

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA;

ARTICLE; ENZYME SUBUNIT; GENE DELETION; HUMAN; HUMAN CELL; MALE; MALE INFERTILITY; OLIGOSPERMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SPERMATOGONIUM; SPERMATOZOON;

EID: 0035140211     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/7.1.103     Document Type: Article

References (47)

1. Sequence and organisation of the human mitochondrial genome
2. Prognostic significance of computerized motility analysis for in vivo fertility
3. Clinical value of sperm morphology for in-vivo fertility: Comparison between World Health Organization criteria of 1987 and 1992
4. Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age
5. Semen levels of mitochondrial DNA deletions in men attending an infertility clinic do not correlate with phenotype
6. Molecular biology of human male infertility: Links with ageing, mitochondrial genetics and oxidative stress
7. Reactive oxygen species and sperm physiology
8. Different cellular backgrounds confer a marked advantage to either mutant or wildtype mitochondrial genomes
9. Detection of mitochondrial DNA deletions by a screening procedure using the polymerase chain reaction
10. Mitochondrial disease and reduced sperm motility
11. Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm
12. Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts
13. Mitochondrial DNA is synthesized during meiosis and spermiogenesis in the mouse
14. Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: Segregation, maintenance and recombination dependent upon nuclear background
15. Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease, and senescence
16. Epidemiology and aetiology of male infertility
17. Long-extension PCR to detect deleted mitochondrial DNA molecules is compromised by technical artefacts
18. Multiple deletions of mitochondrial DNA are associated with the decline of motility and fertility of human spermatozoa
19. Mitochondrial deoxyribnucleic acid 4977 bp deletion is associated with diminished fertility and motility of human sperm
20. Fragmentation of human heart mitochondrial DNA associated with premature aging
21. A microdeletion in cytochrome c oxidase (COX) subunit-III associated with cox deficiency and recurrent myoglobinuria
22. Origin of reactive oxygen species in human semen spermatozoa or leukocytes?
23. Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions
24. Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans
25. A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein
26. Differential accumulations of 4977 bp deletion in mitochondrial DNA of various tissues in human ageing
27. Oligoasthenospermia associated with multiple mitochondrial DNA rearrangements
28. Whole mitochondrial genome amplification reveals basal level multiple deletions in mtDNA of patients with dilated cardiomyopathy
29. Homopolymeric tract heteroplasmy in mtDNA from tissues and single oocytes: Support for a genetic bottleneck
30. Specific mitochondrial DNA deletions in idiopathic dilated cardiomyopathy
31. Mini-Percoll a new method of semen preparation for IVF in severe male factor infertility
32. Mechanism of somatic mitochondrial DNA mutations associated with age and diseases
33. Quantitative determination of deleted mitochondrial DNA relative to normal DNA in Parkinsonian striatum by a kinetic PCR analysis
34. Evidence that specific mtDNA point mutations may not accumulate in skeletal-muscle during normal human aging
35. Long PCR analysis of human gamete mtDNA suggests defective mitochondrial maintenance in spermatozoa and supports the bottleneck theory for oocytes
36. Accumulation of deletions in human mitochondrial DNA during normal aging analysis by quantitative PCR
37. Detection and quantification of mitochondrial DNA deletions
38. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
39. A role for mitochondrial DNA in sperm survival
40. Stategy of oxidative metabolism in bull spermatozoa
41. Oxidative phosphorylation dysfunction does not increase the rate of accumulation of age-related mtDNA deletions in skeletal muscle
42. Prospective study of leukocytes and leukocyte subpopulations in semen suggests they are not a cause of male infertility
43. Ageing-associated 5 kb deletion in human liver mitochondrial DNA
44. Multiple mitochondrial DNA deletions in an elderly human individual
45. Unusual pattern of mitochondrial DNA deletions in skeletal muscle of an adult human with chronic fatigue syndrome
46. Mitochondrial DNA deletions in human cardiac tissue show a gross mosaic distribution