Multiple deletions of mitochondrial DNA are associated with the decline of motility and fertility of human spermatozoa

Molecular Human Reproduction

Volumn 4, Issue 7, 1998, Pages 657-666

  Kao, Shu Huei ^a   Chao, Hsiang Tai ^b   Wei, Yau Huei ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Deletion; Fertility; Mitochondrial DNA; Motility; Spermatozoa

Indexed keywords

MITOCHONDRIAL DNA;

ARTICLE; ASTHENOSPERMIA; CONTROLLED STUDY; DNA DETERMINATION; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; MALE; MALE INFERTILITY; OLIGOSPERMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPERMATOZOON MOTILITY;

BASE SEQUENCE; CLONING, MOLECULAR; DNA, MITOCHONDRIAL; HUMANS; INFERTILITY, MALE; MALE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; SPERM MOTILITY;

EID: 0031826410     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/4.7.657     Document Type: Article

References (36)

1. Aitken, R.J., Best, F.S.M., Richardson, D.W. et al. (1982) The correlates of fertilizing capacity in normal fertile men. Fertil. Steril., 38, 68-76.
2. Aitken, R.J. and Clarkson, J.S. (1988) Significance of reactive oxygen species and antioxidants in defining the efficacy of sperm penetration techniques J. Androl., 9, 367-376.
3. Aitken, R.J., Clarkson, J.S. and Fisel, S. (1989) Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol. Reprod., 40, 183-197.
4. Aitken, R J., Sutton, M., Warner, P. et al. (1985) Relationship between the movement characteristics of human spermatozoa and their ability to penetrate cervical mucus and zona-free hamster oocyte J. Reprod. Fertil , 73, 441-449.
5. Alcivar, A A., Hake, L.E., Millette, C.F. et al. (1989) Mitochondnal gene expression in male germ cells of the mouse. Dev. Biol., 135, 263-271.
6. Chen, X., Prosser, R., Simonetti, S. et al. (1995) Rearranged mitochondrial genomes are present in human oocytes. Am. J. Hum. Genet., 57, 239-247.
7. Fraga, C.G., Motchnik, P A., Wyrobek, A.J. et al. (1996) Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat. Res., 351, 199-203.
8. Fukunaga, M. and Yielding, K.L. (1979) Fate during cell growth of yeast mitochondrial and nuclear DNA after photolytic attachment of the monoazide analog of ethidium bromide. Biochem. Biophys. Res. Commun., 90, 582-586.
9. Holt, I.J., Harding, A.E., Cooper, J.M. et al. (1989) Mitochondrial myopathies: clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA. Ann. Neurol., 29, 699-710.
10. Hou, J.H. and Wei, Y.H. (1996) The unusual structures of the hot-regions flanking large-scale deletions in human mitochondrial DNA. Biochem. J., 318, 1065-1070.
11. Hull, M.G.R., Glazener, C.M.A., Kelly, N.J. et al. (1985) Population study of causes, treatment, and outcome of infertility. Br. Med. J., 291, 1693-1697.
12. Johns, D.R., Rutledge, S.L., Stine, O.C. et al. (1989) Directly repeated sequences associated with pathogenic mitochondrial DNA deletions. Proc. Natl. Acad. Sci. USA, 86, 8059-8062.
13. Johnson, L. (1988) Spermatogenesis (animal species and humans). In Asch, R.H., Balmaceda, J.P., and Johnston, I. (eds), Gamete Physiology. Serono Symposia, Norwell, MA, USA, pp. 3-18.
14. Kao, S.H., Chao, H.T. and Wei Y.H. (1995) Mitochondrial deoxyribonucleic acid 4977-bp deletion is associated with diminished fertility and motility of human sperm. Biol. Reprod., 52, 729-736.
15. Kitagawa, T., Suganuma, N., Nawa, A. et al. (1993) Rapid accumulation of deleted mitochondrial deoxyribonucleic acids in postmenopausal ovaries. Biol. Reprod., 49, 730-736.
16. Lee, H.C., Pang, C.Y., Hsu, H.S. et al. (1994) Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing. Biochim Biophys. Acta, 1226, 37-43.
17. Lee, H.C. and Wei, Y.H. (1997) Mutation and oxidative damage of mitochondrial DNA and defective turnover of mitochondria in human aging. J. Formos. Med. Assoc., 96, 770-718.
18. Lestienne, P., Bataille, N. and Lucas-Heron, B. (1995) Role of mitochondrial DNA and calmitine in myopathies. Biochim. Biophys. Acta, 1271, 159-163.
19. Lestienne, P., Reynier, P., Chretien, M.F. et al. (1997) Oligoasthenospermia associated with multiple mitochondrial DNA rearrangements. Mol. Hum. Reprod., 3, 811-814.
20. Manfredi, G., Thyagarajan, D., Papadopoulou, L.C. et al. (1997) The fate of human sperm-derived mtDNA in somatic cells. Am. J. Hum. Genet., 61, 953-960.
21. Miller, D., Tang, P.Z., Skinner C. et al. (1994) Differential RNA fingerprinting as a tool in the analysis of spermatozoa gene expression. Hum. Reprod., 9, 864-869.
22. Mita, S., Rizzulo, R., Moraes, C T. et al (1990) Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA. Nucleic Acids Res., 18, 561-567.
23. Mortimer D., Pandy, I.J. and Sawers, R.S. (1986) Relationship between human sperm motility characteristics and sperm penetration into cervical mucus in vitro. J. Reprod. Fertil., 78, 93-102.
24. Overstreet, T.W. (1983) Transport of gametes in the reproductive tract of female mammal. In Hartman, J.F.(ed.), Mechanism and Control of Animal Fertilization. Academic Press, New York, USA, pp. 499-543.
25. Poulton, J., Deadman, M.E., Bindoff, L. et al. (1993) Families of mtDNA rearrangement can be detected in patients with mtDNA deletions: duplications may be a transient intermediate form. Hum. Mol. Genet., 2, 23-30.
26. Poulton, J. and Holt, I.J. (1994) Mitochondrial DNA: does more lead to less? Nature Genet., 8, 313-315.
27. Rao, J.C.B. and Martin, S.M. (1989) Lipid peroxidation in human spermatozoa are related to midpiece abnormalities and motility. Gamete Res., 24, 127-134.
28. Seitz, J., Mobius, J., Bergmann, M. et al. (1995) Mitochondrial differentiation during meiosis of male germ cells. Int. J. Androl., 18 (Suppl. 2), 7-11.
29. Sherratt, E.J., Thomas, A.W. and Alcolado, J.C. (1997) Mitochondrial DNA defects: a widening clinical spectrum of disorders. Clin. Sci., 92, 225-235.
30. Shoffner, J.M., Lott, A.S., Voljavec, A.S. et al. (1989) Spontaneous Kearns-Sayre/chronic progressive external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slip-replication model and metabolic therapy. Proc. Natl. Acad. Sci. USA, 86, 7952-7956.
31. Shoffner, J.M., and Wallace, D C. (1994) Oxidative phosphorylation disease and mitochondrial DNA mutations: diagnosis and treatment. Ann. Rev. Nutr., 14, 535-568.
32. Tredway, D R., Settlage, D.S.F., Nakamura, R.M. et al. (1975) Significance of timing for the post-coital evaluation of cervical mucus. Am. J. Obstet. Gynecol., 121, 287-293.
33. Wallace, D.C. (1994) Mitochondrial DNA sequence variation in human evolution and disease. Proc. Natl. Acad Sci. USA, 91, 8739-8746.
34. Wei, Y.H. (1998) Oxidative stress and mitochondrial DNA mutations in human aging. Proc. Soc. Exp. Biol Med., 217, 53-63.
35. Yakes, F.M. and van Houton, B. (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. USA, 94, 514-519.
36. Yen, T.C., Su, J.H., King, K.L. et al. (1991) Ageing-associated 5 kb deletion in human liver mitochondrial DNA. Biochem. Biophys. Res. Commun., 178, 124-131.