Potential role of size and hemodynamics in the efficacy of vascular-targeted spherical drug carriers

Biomaterials

Volumn 31, Issue 6, 2010, Pages 1392-1402

  Charoenphol, Phapanin ^a   Huang, Ryan B ^a   Eniola Adefeso, Omolola ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Blood flow; Inflammation; Margination; Nanoparticles; Red blood cells; Vascular targeting

Indexed keywords

ANTI-GRAVITY; BINDING EFFICIENCY; BLOOD FLOW; BLOOD RHEOLOGY; CARDIO-VASCULAR DISEASE; CHANNEL HEIGHT; DRUG CARRIER; HUMAN DISEASE; IN-VITRO; LOCALIZED DELIVERY; NANO-SIZED PARTICLES; PARALLEL PLATE FLOW CHAMBER; POLYMERIC SPHERE; PULSATILITY; RED BLOOD CELL; SPHERICAL PARTICLE; VASCULAR WALL; VERTICAL CHANNELS; VESSEL SIZE; WALL SHEAR RATES; WORK FOCUS;

ADHESION; BLOOD; CELLS; HEMODYNAMICS; HEMOGLOBIN OXYGEN SATURATION; HYDRODYNAMICS; NANOPARTICLES; PATHOLOGY; SHEAR DEFORMATION; SULFUR COMPOUNDS;

SPHERES;

DRUG CARRIER; NANOPARTICLE; NANOSPHERE; POLYMER;

ADHESION; ARTERY DIAMETER; ARTICLE; BINDING AFFINITY; BLOOD FLOW; BLOOD RHEOLOGY; BLOOD VESSEL DIAMETER; BLOOD VESSEL WALL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENDOTHELIUM CELL; ERYTHROCYTE; HEMODYNAMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; PARTICLE SIZE; PRIORITY JOURNAL; SHEAR RATE; SHEAR STRESS; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; VENULE;

BLOOD FLOW VELOCITY; CELLS, CULTURED; DRUG CARRIERS; ENDOTHELIUM, VASCULAR; FEASIBILITY STUDIES; HUMANS; MATERIALS TESTING; MICROSPHERES; NANOPARTICLES; PARTICLE SIZE; POLYSTYRENES;

EID: 72149100143     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.11.007     Document Type: Article

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