Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: A reflection of Th17 cells activation?

Acta Neurologica Scandinavica

Volumn 122, Issue 6, 2010, Pages 425-429

  Rentzos, M ^a   Rombos, A ^a   Nikolaou, C ^a   Zoga, M ^a   Zouvelou, V ^a   Dimitrakopoulos, A ^a   Alexakis, T ^a   Tsoutsou, A ^a   Samakovli, A ^a   Michalopoulou, M ^a   Evdokimidis, J ^a  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Amyotrophic lateral sclerosis; Enzyme like immunosorbent assay; Immunological disturbances; Interleukin 17; Interleukin 23; Th17 activation

Indexed keywords

BIOLOGICAL MARKER; INTERLEUKIN 17; INTERLEUKIN 23;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOIMMUNITY; CELL ACTIVATION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISABILITY SEVERITY; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; PATHOGENESIS; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN FUNCTION; TH17 CELL;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-17; INTERLEUKIN-23; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC;

EID: 77958614693     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2010.01333.x     Document Type: Article

References (33)

1. Agar J, Durham H. Relevance of oxidative injury in the pathogenesis of motor neuron diseases. Amyotroph Lateral Scler Other Motor Neuron Disord 2003;4:232-42.
2. Menzies FM, Ince PG, Shaw PJ. Mitochondrial involvement in amyotrophic lateral sclerosis. Neurochem Int 2002;40:543-51.
3. Heath PR, Shaw PJ. Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve 2002;26:438-58.
4. Rakhit R, Cunningham P, Furtos-Matei A et al. Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis. J Biol Chem 2002;277:47551-6.
5. Troost D, Van Den Oord JJ, De Jong JM, Swaab DF. Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis. Clin Neuropathol 1989; 8:289-94.
6. Troost D, Van Den Oord JJ, Vianney de Jong JM. Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol 1990;16:401-10.
7. Kawamata T, Akiyama H, Yamada T, McGeer PL. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol 1992;140:691-707.
8. Engelhardt JI, Tajti J, Appel SH. Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis. Arch Neurol 1993;50:30-6.
9. Steinman L. A brief history of TH.17, the first major revision in the TH.1/TH.2 hypothesis of T cell-mediated tissue damage. Nat Med 2007;13:139-45.
10. Trinchieri G, Pflanz S, Kastelein RA. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 2005;19:641-4.
11. Harrington LE, Hatton RD, Mangan PR et al.Interleukin-17-producing CD4+ effect T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123-32.
12. Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol 2006;18:349-56.
13. Brooks M, Miller R, Swash M, Munsat T. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2000;1:293-9.
14. Cedarbaum J, Stambler N, Malta E et al. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. J Neurol Sci 1999;169:13-21.
15. Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007;8:345-50.
16. Cua DJ, Sherlock J, Chen Y et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003;421:744-8.
17. Wiekowski MT, Leach MW, Evans EW et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J Immunol 2001;166:7563-70.
18. Komiyama Y, Nakae S, Matsuki T et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 2006;177:566-73.
19. Dembinsky AV, Murugaiyan G, Hafler DA et al. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J Neuroimmunol 2008;195:140-5.
20. Infante-Duarte C, Horton HF, Byrne MC, Kamradt T. Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol 2000;165:6107-15.
21. Dodon MD, Li Z, Hamaia S, Gazzolo L. Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells. J Gen Virol 2004;85:1921-32.
22. Tanaka M, Kikuchi H, Ishizu T et al. Intrathecal upregulation of G-CSF and its neuroprotective actions on motor neurons in ALS. J Neuropathol Exp Neurol 2006;65:816-25.
23. Ono S, Hu J, Shimizu N et al. Increased interleukin-6 of skin and serum in amyotrophic lateral sclerosis. J Neurol Sci 2001;187:27-34.
24. Panzara MA, Gussoni E, Begovich AB et al. T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic multiple sclerosis. Neurobiol Dis 1999;6:392-405.
25. Ilzecka J, Stelmasiak Z, Dobosz B. Transforming growth factor-beta 1 (TGF-beta 1) in patients with amyotrophic lateral sclerosis. Cytokine 2002;20:239-43.
26. Sekizawa T, Openshaw H, Obbo K et al. Cerebrospinal fluid interleukin-6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non inflammatory central nervous system diseases. J Neurol Sci 1998;154:194-9.
27. Holmøy T, Roos Per M, Kvale E. ALS: cytokine profile in cerebrospinal fluid T-cell clones. Amyotroph Lateral Scler 2006;7:183-6.
28. Ford L, Rowe D. Interleukin-12 and interferon-gamma are not detectable in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2004;5:118-20.
29. Vladić A, Horvat G, Vukadin S et al. Cerebrospinal fluid and serum protein levels of TNF-a, IL-6 and soluble IL-6 receptor (SIL-6Rgp80) in multiple sclerosis patients. Cytokine 2002;20:86-9.
30. Holmoy T. T cells in amyotrophic lateral sclerosis. Eur J Neurol 2008;15:360-6.
31. Dunckley T, Huentelman MJ, Craig DW et al. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. N Engl J Med 2007;357:775-88.
32. Wills AM, Cronin S, Slowik A et al. A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology 2009;73:16-24.
33. Valdmanis PN, Daoud H, Dion PA, Rouleau GA. Recent advances in the genetics of amyotrophic lateral sclerosis. Curr Neurol Neurosci Rep 2009;9:198-205.