Decreased expression of the rat myometrial relaxin receptor (RXFP1) in late pregnancy is partially Mediated by the Presence of the conceptus

Biology of Reproduction

Volumn 83, Issue 5, 2010, Pages 818-824

  Vodstrcil, Lenka A ^a   Shynlova, Oksana ^b   Verlander, Jill W ^c   Wlodek, Mary E ^a   Parry, Laura J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Myometrium; Parturition; Pregnancy; Relaxin; Reproductive tract; RXFP1

Indexed keywords

PROTEIN RXFP1; RECEPTOR; RELAXIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DECIDUA; DOWN REGULATION; ENDOMETRIUM; FETOPLACENTAL UNIT; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOREACTIVITY; LABOR; MOUSE; MYOMETRIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUERPERIUM; RAT; REGULATORY MECHANISM; RNA TRANSLATION; RXFP1 GENE; SECOND TRIMESTER ABORTION; THIRD TRIMESTER PREGNANCY; UTERUS CONTRACTION;

ANIMALS; CERVIX UTERI; DECIDUA; DOWN-REGULATION; FEMALE; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; MUSCLE, SMOOTH; MYOMETRIUM; ORGAN SPECIFICITY; PLACENTA; POSTPARTUM PERIOD; PREGNANCY; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RNA, MESSENGER; UTERUS; VAGINA;

ANIMALIA; MUS; RATTUS;

EID: 77958587330     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.110.083931     Document Type: Article

References (43)

1. Challis JRG, Matthews SG, Gibb W, Lye SJ. Endocrine and paracrine regulation of birth at term and preterm. Endocr Rev 2000; 21:514-550.
2. Lye SJ, Mitchell J, Nashman N, Oldenhof A, Ou R, Shynlova O, Langille L. Role of mechanical signals in the onset of term and preterm labor. Front Horm Res 2001; 27:165-178.
3. Goldsmith LT, Skurnick JH, Wojtczuk AS, Linden M, Kuhar MJ, Weiss G. The antagonistic effect of oxytocin and relaxin on rat uterine segment contractility. Am J Obstet Gynecol 1989; 161:1644-1649.
4. Downing SJ, Hollingsworth M. Action of relaxin on uterine contractions - a review. J Reprod Fertil 1993; 99:275-282.
5. MacLennan AH, Grant P, Ness D, Down A. Effect of porcine relaxin and progesterone on rat, pig and human myometrial activity in vitro. J Reprod Med 1986; 31:43-49.
6. Longo M, Jain V, Vedernikov YP, Garfield RE, Saade GR. Effects of recombinant human relaxin on pregnant rat uterine artery and myometrium in vitro. Am J Obstet Gynecol 2003; 188:1468-1476.
7. Porter DG, Downing SJ, Bradshaw JM. Relaxin inhibits spontaneous and prostaglandin-driven myometrial activity in anesthetized rats. J Endocrinol 1979; 83:183-192.
8. Porter DG, Watts AD. Relaxin and progesterone are myometrial inhibitors in the ovariectomized nonpregnant mini-pig. J Reprod Fertil 1986; 76:205-213.
9. Downing SJ, Sherwood OD. The physiological role of relaxin in the pregnant rat. II. The influence of relaxin on uterine contractile activity. Endocrinology 1985; 116:1206-1214.
10. Weiss TJ, Bryant-Greenwood GD. Localization of relaxin binding sites in the rat uterus and cervix by autoradiography. Biol Reprod 1982; 27:673-679.
11. Mercado-Simmen RC, Goodwin B, Ueno MS, Yamamoto SY, Bryant- Greenwood GD. Relaxin receptors in the myometrium and cervix of the pig. Biol Reprod 1982; 26:120-128.
12. Tan YY, Wade JD, Tregear GW, Summers RJ. Quantitative autoradiographic studies of relaxin binding in rat atria, uterus and cerebral cortex: characterization and effects of estrogen treatment. Br J Pharmacol 1999; 127:91-98.
13. Kohsaka T, Min G, Lukas G, Trupin S, Campbell ET, Sherwood OD. Identification of specific relaxin-binding cells in the human female. Biol Reprod 1998; 59:991-999. (Pubitemid 28463355)
14. Einspanier A, Muller D, Lubberstedt J, Bartsch O, Jurdzinski A, Fuhrmann K, Ivell R. Characterization of relaxin binding in the uterus of the marmoset monkey. Mol Hum Reprod 2001; 7:963-970.
15. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJW. Activation of orphan receptors by the hormone relaxin. Science 2002; 295:671-674.
16. Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol Rev 2006; 58:7-31.
17. Krajnc-Franken MAM, van Disseldorp JM, Koenders JE, Mosselman S, van Duin M, Gossen JA. Impaired nipple development and parturition in LGR7 knockout mice. Mol Cell Biol 2004; 24:687-696.
18. Siebel AL, Gehring HM, Reytomas IGT, Parry LJ. Inhibition of oxytocin receptor and estrogen receptor-a, but not relaxin receptors (LGR7), in the myometrium of late pregnant relaxin gene knockout mice. Endocrinology 2003; 144:4272-4275.
19. Vodstrcil LA, Wlodek ME, Parry LJ. Effects of uteroplacental restriction on the relaxin-family receptors, Lgr7 and Lgr8, in the uterus of late pregnant rats. Reprod Fertil Dev 2007; 19:530-538.
20. Ou CW, Orsino A, Lye SJ. Expression of connexin-43 and connexin-26 in the rat myometrium during pregnancy and labor is differentially regulated by mechanical and hormonal signals. Endocrinology 1997; 138:5398-5407.
21. Ou CW, Chen ZQ, Qi S, Lye SJ. Increased expression of the rat myometrial oxytocin receptor messenger ribonucleic acid during labor requires both mechanical and hormonal signals. Biol Reprod 1998; 59:1055-1061.
22. Shynlova O, Williams SJ, Draper H, White BG, MacPhee DJ, Lye SJ. Uterine stretch regulates temporal and spatial expression of fibronectin protein and its alpha 5 integrin receptor in myometrium of unilaterally pregnant rats. Biol Reprod 2007; 77:880-888.
23. Wu WX, Ma XH, Yoshizato T, Shinozuka N, Nathanielsz PW. Differential expression of myometrial oxytocin receptor and prostaglandin H synthase 2, but not estrogen receptor alpha and heat shock protein 90 messenger ribonucleic acid in the gravid horn and nongravid horn in sheep during betamethasone-induced labor. Endocrinology 1999; 140:5712-5718.
24. Parry LJ, Bathgate RA, Shaw G, Renfree MB, Ivell R. Evidence for a local fetal influence on myometrial oxytocin receptors during pregnancy in the tammar wallaby (Macropus eugenii). Biol Reprod 1997; 56:200-207.
25. Scott DJ, Layfield S, Yan Y, Sudo S, Hsueh AJ, Tregear GW, Bathgate RA. Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem 2006; 281:34942-34954.
26. Kern A, Agoulnik AI, Bryant-Greenwood GD. The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane. Endocrinology 2007; 148:1181-1194.
27. Kern A, Bryant-Greenwood GD. Characterization of relaxin receptor (RXFP1) desensitization and internalization in primary human decidual cells and RXFP1-transfected HEK293 cells. Endocrinology 2009; 150:2419-2428.
28. Novak J, Parry LJ, Matthews JE, Kerchner LJ, Indovina K, Hanley-Yanez K, Doty KD, Debrah DO, Shroff SG, Conrad KP. Evidence for local relaxin ligand-receptor expression and function in arteries. FASEB J 2006; 20:2352-2362.
29. -/-) mice. Ann N Y Acad Sci 2005; 1041:104-109.
30. -/-) mouse. Ann N Y Acad Sci 2005; 1041:91-103.
31. Rao MR, Sanborn BM. Relaxin increases calcium efflux from rat myometrial cells in culture. Endocrinology 1986; 119:435-437.
32. Hsu CJ, Sanborn BM. Relaxin treatment alters the kinetic properties of myosin light chain kinase activity in rat myometrial cells in culture. Endocrinology 1986; 118:499-505.
33. Anwer K, Hovington JA, Sanborn BM. Involvement of protein kinase A in the regulation of intracellular free calcium and phosphoinositide turnover in rat myometrium. Biol Reprod 1990; 43:851-859.
34. Meera P, Anwer K, Monga M, Oberti C, Stefani E, Toro L, Sanborn BM. Relaxin stimulates myometrial calcium-activated potassium channel activity via protein kinase A. Am J Physiol 1995; 269:C312-C317.
35. Zhong M, Murtazina DA, Phillips J, Ku CY, Sanborn BM. Multiple signals regulate phospholipase Cbeta3 in human myometrial cells. Biol Reprod 2008; 78:1007-1017.
36. Sanborn BM, Ku CY, Shlykov S, Babich L. Molecular signaling through G-protein-coupled receptors and the control of intracellular calcium in myometrium. J Soc Gynecol Investig 2005; 12:479-487.
37. Heng K, Ivell R, Wagaarachchi P, Anand-Ivell R. Relaxin signaling in primary cultures of human myometrial cells. Mol Hum Reprod 2008; 14:603-611.
38. Chamley WA, Parkington HC. Relaxin inhibits the plateau component of the action potential in the circular myometrium of the rat. J Physiol 1984; 353:51-65.
39. Doualla-Bell F, Lye SJ, Labrie F, Fortier MA. Differential expression and regulation of connexin-43 and cell-cell coupling in myocytes from the circular and longitudinal layers of bovine myometrium. Endocrinology 1995; 136:5322-5328.
40. Shynlova O, Tsui P, Dorogin A, Chow M, Lye SJ. Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium. Biol Reprod 2005; 73:773-780.
41. Sherwood OD, Crnekovic VE. Development of a homologous radioimmunoassay for rat relaxin. Endocrinology 1979; 104:893-897.
42. Yan W, Chen J, Wiley A, Crean-Harris B, Bartol F, Bagnell C. Relaxin (RLX) and estrogen affect estrogen receptor alpha, vascular endothelial growth factor and RLX receptor expression in the neonatal porcine uterus and cervix. Reproduction 2008; 135:705-712.
43. Mercado-Simmen RC, Bryant-Greenwood GD, Greenwood FC. Relaxin receptor in the rat myometrium: regulation by estrogen and relaxin. Endocrinology 1982; 110:220-226.