Uterine stretch regulates temporal and spatial expression of fibronectin protein and its alpha 5 integrin receptor in myometrium of unilaterally pregnant rats

Biology of Reproduction

Volumn 77, Issue 5, 2007, Pages 880-888

  Shynlova, Oksana ^a   Williams, S Joy ^c   Draper, Haley ^a   White, Bryan G ^c   MacPhee, Daniel J ^c   Lye, Stephen J ^a,b,d  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Cellular cohesion; Pregnancy; Progesterone; Uterus

Indexed keywords

ALPHA5 INTEGRIN; FIBRONECTIN; MESSENGER RNA; RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; IMMUNOBLOTTING; MUSCLE STRETCHING; MYOMETRIUM; NONHUMAN; NORTHERN BLOTTING; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UTERUS; UTERUS GROWTH; UTERUS HORN;

ANIMALS; FEMALE; FIBRONECTINS; INTERLEUKIN-5 RECEPTOR ALPHA SUBUNIT; MENSTRUATION-INDUCING AGENTS; MIFEPRISTONE; MYOMETRIUM; PREGNANCY; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; UTERINE CONTRACTION; UTERUS;

RATTUS;

EID: 35548939779     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.107.062356     Document Type: Article

References (44)

1. Cullen BM, Harkness RD. Collagen formation and changes in cell population in the rat's uterus after distension with wax. Q J Exp Physiol Cogn Med Sci 1968; 53:33-42.
2. Goldspink DF, Douglas AJ. Protein turnover in gravid and nongravid horns of uterus in pregnant rats. Am J Physiol 1988; 254:E549-E554.
3. Csapo A, Erdos T, De Mattos CR, Gramss E, Moscowitz C. Stretch-induced uterine growth, protein synthesis and function. Nature 1965; 207:1378-1379.
4. Shynlova O, Mitchell JA, Tsampalieros A, Langille BL, Lye SJ. Progesterone and gravidity differentially regulate expression of extracellular matrix components in the pregnant rat myometrium. Biol Reprod 2004; 70:986-992.
5. MacPhee DJ, Mostachfi H, Han R, Lye SJ, Post M, Caniggia I. Focal adhesion kinase is a key mediator of human trophoblast development. Lab Invest 2001; 81:1469-1483.
6. Hanks SK, Polte TR. Signaling through focal adhesion kinase. Bioessays 1997; 19:137-145.
7. Wozniak MA, Modzelewska K, Kwong L, Keely PJ. Focal adhesion regulation of cell behavior. Biochim Biophys Acta 2004; 1692:103-119.
8. Qin L, Wang YL, Bai SX, Ji SH, Qiu W, Tang S, Piao YS. Temporal and spatial expression of integrins and their extracellular matrix ligands at the maternal-fetal interface in the rhesus monkey during pregnancy. Biol Reprod 2003; 69:563-571.
9. Robinson EE, Foty RA, Corbett SA. Fibronectin matrix assembly regulates alpha5beta1-mediated cell cohesion. Mol Biol Cell 2004; 15:973-981.
10. Woodward TL, Mienaltowski AS, Modi RR, Bennett JM, Haslam SZ. Fibronectin and the alpha(5)beta(1) integrin are under developmental and ovarian steroid regulation in the normal mouse mammary gland. Endocrinology 2001; 142:3214-3222.
11. Goldsmith EC, Price R, Carver W, Weinberg EO, Ding B, Borg TK. The role of alpha(5)beta(1)integrin in the transition from cardiac hypertrophy to failure. Circulation 1999; 100:2952.
12. Hynes RO. Fibronectins. In: Rich A (ed.), Springer Series in Molecular Biology. New York: Springer-Verlag; 1990.
13. Wierzbicka-Patynowski I, Schwarzbauer JE. The ins and outs of fibronectin matrix assembly. J Cell Sci 2003; 116:3269-3276.
14. Williams SJ, White BG, MacPhee DJ. Expression of alpha5 integrin (Itga5) is elevated in the rat myometrium during late pregnancy and labor: implications for development of a mechanical syncytium. Biol Reprod 2005; 72:1114-1124.
15. Ou CW, Chen ZQ, Qi S, Lye SJ. Increased expression of the rat myometrial oxytocin receptor messenger ribonucleic acid during labor requires both mechanical and hormonal signals. Biol Reprod 1998; 59:1055-1061.
16. Piersanti M, Lye SJ. Increase in messenger ribonucleic acid encoding the myometrial gap junction protein, connexin-43, requires protein synthesis and is associated with increased expression of the activator protein-1, c-fos. Endocrinology 1995; 136:3571-3578.
17. Beckstead JH. A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues. J Histochem Cytochem 1994; 42:1127-1134.
18. Oldenhof AD, Shynlova OP, Liu M, Langille BL, Lye SJ. Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells. Am J Physiol Cell Physiol 2002; 283:C1530-C1539.
19. Pepe GJ, Rothchild I. A comparative study of serum progesterone levels in pregnancy and in various types of pseudopregnancy in the rat. Endocrinology 1974; 95:275-279.
20. Shynlova O, Oldenhof A, Dorogin A, Xu Q, Mu J, Nashman N, Lye SJ. Myometrial apoptosis: activation of the caspase cascade in the pregnant rat myometrium at midgestation. Biol Reprod 2006; 74:839-849.
21. Shynlova O, Tsui P, Dorogin A, Langille BL, Lye SJ. Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat. Biol Reprod 2007; 76:571-578.
22. Douglas AJ, Clarke EW, Goldspink DF. Influence of mechanical stretch on growth and protein turnover of rat uterus. Am J Physiol 1988; 254:E543-E548.
23. Ross RS. The extracellular connections: the role of integrins in myocardial remodeling. J Card Fail 2002; 8:S326-S331.
24. Terracio L, Rubin K, Gullberg D, Balog E, Carver W, Jyring R, Borg TK. Expression of collagen binding integrins during cardiac development and hypertrophy. Circ Res 1991; 68:734-744.
25. Babbitt CJ, Shai SY, Harpf AE, Pham CG, Ross RS. Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle. Histochem Cell Biol 2002; 118:431-439.
26. Keller RS, Shai SY, Babbitt CJ, Pham CG, Solaro RJ, Valencik ML, Loftus JC, Ross RS. Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance. Am J Pathol 2001; 158:1079-1090.
27. Schwarzbauer JE. Fibronectin: from gene to protein. Curr Opin Cell Biol 1991; 3:786-791.
28. Pulkkinen MO, Lehto M, Jalkanen M, Nanto-Salonen K. Collagen types and fibronectin in the uterine muscle of normal and hypertensive pregnant patients. Am J Obstet Gynecol 1984; 149:711-717.
29. Schwarzbauer JE, Sechler JL. Fibronectin fibrillogenesis: a paradigm for extracellular matrix assembly. Curr Opin Cell Biol 1999; 11:622-627.
30. Wierzbicka-Patynowski I, Schwarzbauer JE. The ins and outs of fibronectin matrix assembly. J Cell Sci 2003; 116:3269-3276.
31. Hedin U, Bottger BA, Luthman J, Johansson S, Thyberg J. A substrate of the cell-attachment sequence of fibronectin (Arg-Gly-Asp-Ser) is sufficient to promote transition of arterial smooth muscle cells from a contractile to a synthetic phenotype. Dev Biol 1989; 133:489-501.
32. Thyberg J. Differentiated properties and proliferation of arterial smooth muscle cells in culture. Int Rev Cytol 1996; 169:183-265.
33. Schlaepfer DD, Hauck CR, Sieg DJ. Signaling through focal adhesion kinase. Prog Biophys Mol Biol 1999; 71:435-478.
34. Gerthoffer WT, Gunst SJ. Invited review: focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle. J Appl Physiol 2001; 91:963-972.
35. Upadhyay J, Aitken KJ, Damdar C, Bolduc S, Bagli DJ. Integrins expressed with bladder extracellular matrix after stretch injury in vivo mediate bladder smooth muscle cell growth in vitro. J Urol 2003; 169:750-755.
36. Schoenwaelder SM, Burridge K. Bidirectional signaling between the cytoskeleton and integrins. Curr Opin Cell Biol 1999; 11:274-286.
37. Doualla-Bell F, Lye SJ, Labrie F, Fortier MA. Differential expression and regulation of connexin-43 and cell-cell coupling in myocytes from the circular and longitudinal layers of bovine myometrium. Endocrinology 1995; 136:5322-5328.
38. Shynlova O, Tsui P, Dorogin A, Chow M, Lye SJ. Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium. Biol Reprod 2005; 73:773-780.
39. Shynlova O, Tsui P, Dorogin A, Langille BL, Lye SJ. The expression of transforming growth factor β in pregnant rat myometrium is hormone and stretch dependent. Reproduction 2007; 134:503-511.
40. Robinson EE, Zazzali KM, Corbett SA, Foty RA. Alpha5beta1 integrin mediates strong tissue cohesion. J Cell Sci 2003; 116:377-386.
41. Roovers K, Assoian RK. Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases. Mol Cell Biol 2003; 23:4283-4294.
42. Aikawa R, Nagai T, Kudoh S, Zou Y, Tanaka M, Tamura M, Akazawa H, Takano H, Nagai R, Komuro I. Integrins play a critical role in mechanical stress-induced p38 MAPK activation. Hypertension 2002; 39:233-238.
43. Wang JG, Miyazu M, Matsushita E, Sokabe M, Naruse K. Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation. Biochem Biophys Res Commun 2001; 288:356-361.
44. Oldenhof AD, Shynlova OP, Liu M, Langille BL, Lye SJ. Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells. Am J Physiol Cell Physiol 2002; 283:C1530-C1539.