Antiproliferative activity of N6-isopentenyladenosine on MCF-7 breast cancer cells: Cell cycle analysis and DNA-binding study

DNA and Cell Biology

Volumn 29, Issue 11, 2010, Pages 687-691

  Rajabi, Mehdi ^a   Signorelli, Paola ^a   Gorincioi, Elena ^a   Ghidoni, Riccardo ^a   Santaniello, Enzo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 N (3,3 DIMETHYLALLYL)ADENOSINE; DNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE PHASE; CELL STRAIN MCF 7; CELL VIABILITY; CYTOTOXICITY; DNA DAMAGE; DRUG DNA BINDING; DRUG DNA INTERACTION; DRUG EFFECT; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; ABSORPTION; BREAST TUMOR; CELL CYCLE; CELL PROLIFERATION; CHEMISTRY; GENETICS; METABOLISM; PATHOLOGY; SPECTROSCOPY; STEREOISOMERISM; TUMOR CELL LINE;

MAMMALIA;

ABSORPTION; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; HUMANS; ISOPENTENYLADENOSINE; SPECTRUM ANALYSIS; STEREOISOMERISM;

EID: 77958584742     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2010.1073     Document Type: Article

References (27)

1. Bagchi, S., and Raychaudhuri, P. (2010). Damaged-DNA binding protein-2 drives apoptosis following DNA damage. Cell Div 5, 1-5.
2. 6-isopentenyladenosine: an emerging anticancer drug. Anti Cancer Agents Med Chem 8, 200-204.
3. 6-isopentenyladenosine. Int J Cancer 124, 2179-2185.
4. Divekar, A.Y., Slocum, H.K., and Hakala, M.T. (1973). N6-(D2-Isopentenyl)adenosine 5'-monophosphate: formation and effect on purine metabolism in cellular and enzymatic systems. Mol Pharm 10, 529-543.
5. Gallo, R.C., Whang-Peng, J., and Perry, S. (1969). Isopentenyla-denosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin. Science 165, 400-402.
6. Hendry, L.B., Mahesh, V.B., Bransome, E.D., and Ewing, D.E. (2007). Small molecule intercalation with double stranded DNA: implications for normal gene regulation and for predicting the biological efficacy and genotoxicity of drugs and other chemicals. Mutat Res 623, 53-71.
7. Ishii, Y., Hori, Y., Sakai, S., and Honma, Y. (2002). Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones. Cell Growth Differ 13, 19-26.
8. Kastan, M.B., and Bartek, J. (2004). Cell-cycle checkpoints and cancer. Nature 432, 316-323.
9. 6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1. Int J Cancer 124, 1322-1329.
10. 6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation. FASEB J 20, 412-418.
11. Meisel, H., Gunther, S., Martin, D., and Schlimme, E. (1998). Apoptosis induced by modified ribonucleosides in human cell culture systems. FEBS Lett 433, 265-268.
12. Mittelman, A., Evans, J.T., and Chheda, G.B. (1975). Cytokinins as chemotherapeutic agents. Ann NY Acad Sci 255, 225-234.
13. Nafisi, S., Hashemi, M., Rajabi, M., and Tajmir-Riahi, H.A. (2008a). DNA adducts with antioxidant flavonoids apigenin, morin and naringin. DNA Cell Biol 27, 433-442.
14. Nafisi, S., Manouchehri, F., Tajmir-Riahi, H.A., and Varavipour, M. (2008b). Structural features of DNA interaction with caffeine and theophylline. J Mol Struct 875, 392-399.
15. Norbury, C.J., and Zhivotovsky, B. (2004). DNA damage-induced apoptosis. Oncogene 23, 2797-2808.
16. Palchaudhuri, R., and Hergenrother, P.J. (2007). DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action. Curr Opin Biotech 18, 497-503.
17. Prudhomme, M. (2004). Combining DNA damaging agents and Chk1 inhibitors. Curr Med Chem Anti Cancer Agents 4, 435-438.
18. 6-Isopentenyladenosine, an isoprenoid cytokinin endowed with biological activity: cytotoxicity against MDA-MB-231 breast cancer cell line and interaction with bovine serum albumin. Iran J Org Chem 2, 278-284.
19. 2-Isopentenyl)adenosine, a component of the transfer ribonu-cleic acid of yeast and of mammalian tissue, methods of isolation, and characterization. Biochemistry 6, 1837-1848.
20. Skehn, P., Storeng, R., Scudiero, D., Monks, A., McMohan, J., Vistica, D., Warren, J.T., Bokesch, H., Kenney, S., and Boyd, M.R. (1990). New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 82, 1107-1112.
21. 6-isopentenyladenosine: a potential therapeutic agent for a variety of epithelial cancers. Int J Cancer 120, 2744-2748.
22. 2-Isopentenyl adenosine, a natural component of mammalian transfer RNA. Cancer Res 30, 1429-1436.
23. Tajmir-Riahi, H.A., Neault, J.F., Naoui, M., and Diamantoglou, S. (1995). The effects of HCl on the solution structure of calf thymus DNA: a comparative study of DNA denaturation by proton and metal cations using Fourier transform IR difference spectroscopy. Biopolymers 35, 493-501.
24. Tao, Z.F., and Lin, N.H. (2006). Chk1 inhibitors for novel cancer treatment. Anticancer Agents Med Chem 6, 377-388.
25. Vichai, V., and Kirtikara, K. (2006). Sulforhodamine B colori-metric assay for cytotoxicity screening. Nat Protoc 1, 1112-1116.
26. Wang, J.Y.J. (2001). DNA damage and apoptosis. Cell Death Diff 8, 1047-1048.
27. Zhou, B.S., and Bartek, J. (2004). Targeting the checkpoint ki-nases: chemosensitization versus chemoprotection. Nat Rev Cancer 4, 1-10.