Supplementation of ascorbic acid prevents oxidative damages in arsenic-loaded hepatic tissue of rat: An ex vivo study

Human and Experimental Toxicology

Volumn 29, Issue 11, 2010, Pages 965-972

  Rana, Tanmoy ^a   Asit Kumar Bera, ^a   Das, Subhashree ^a   Pan, Diganta ^a   Bandyopadhyay, Subhasish ^a   Bhattacharya, Debasis ^a   De, Sumanta ^a   Subrata Kumar Das, ^a  

^a INDIAN VETERINARY RESEARCH INSTITUTE   (India)

Author keywords

arsenic; ascorbic acid; hepatic tissue; oxidative stress

Indexed keywords

ARSENIC; ASCORBIC ACID; CATALASE; NITRIC OXIDE; PROTEIN; PROTEIN CARBONYL; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; EX VIVO STUDY; INCUBATION TIME; LIPID PEROXIDATION; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; RAT; VITAMIN SUPPLEMENTATION;

ANIMALS; ANTIOXIDANTS; ARSENIC; ASCORBIC ACID; CATALASE; ENVIRONMENTAL POLLUTANTS; LIPID PEROXIDATION; LIVER; MALE; NITRIC OXIDE; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TIME FACTORS; TOXICITY TESTS;

RATTUS;

EID: 77958530774     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110364641     Document Type: Article

References (55)

1. Agency for Toxic substances and Disease Registry (ATSDR). Toxicological profile for arsenic., Atlanta, GA: US Public Health Service ; 1993.
2. Gupta R., Flora SJS. Protective value of aloe vera against some toxic effects of arsenic in rats. Phytother Res 2005 ; 19: 23-28.
3. Guha Majumder DN, De BK, Santra A., et al. Randomized placebo-controlled trial of 2,3-dimercaptosuccinic acid in therapy of chronic arsenicosis due to drinking arsenic-contaminated subsoil water. J Toxicol Clin Toxicol 2001 ; 36: 683.
4. Khalequzzaman M., Faruque FS, Mitra AK Assessment of arsenic contamination of ground water and health problems in Bangladesh. Int J Environ Res Public Health 2005 ; 2: 204.
5. Dey S. Management protocol for arsenicosis case: arsenicosis case-detection, management and surveillance. Report of a regional consultation, New Delhi, India, 2002.
6. Rosas I., Belmont R., Armienta A., Baez A. Arsenic concentration in water and soil, milk and forage in Comarca Lagunera, Mexico. Water Air Soil Polutio 1999 ; 112: 133.
7. Dutta DV, Mitra SK, Chhuttani PN, Chakravarti RN Chronic oral arsenic intoxication as a possible aetiological factor in idiopathic portal hypertension (non-cirrhotic portal fibrosis) in India. Gut 1979 ; 20: 378.
8. Nevens F., Fevery J., Streenbergen WV, Sciot R., Desmet V., Groote J. Arsenic and non cirrhotic portal hypertension. J Hepatol 1990 ; 11: 80.
9. Flora SJS. Arsenic induced oxidative stress and its reversibility following combined administration of N-acetyl cysteine and meso-2, 3-dimercaptosuccinic acid in rats. Clin Exp Pharmacol Physiol 1999 ; 26: 865.
10. Ramos O., Carrizales L., Yanez L., Mejia J., Batres L., Ortiz D., et al. Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of glutathione levels. Environ Health Persp 1995 ; 103: 85.
11. Modi M., Mittal M., Flora SJS. Combined administration of selenium and meso-2, 3-dimercaptosuccinic acid on arsenic mobilization and tissue oxidative stress in chronic arsenic-exposed male rats. Indian J Pharmacol 2007 ; 39: 107.
12. Liu SX, Athar M., Lippai I., Waldren C., Hei TK Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc Natl Acad Sci, USA 2001 ; 98: 1643.
13. Ramanathan K., Balakumar BS, Panneer-Selvam C. Effects of ascorbic acid and ±-tocopherol on arsenic induced oxidative stress. Hum Exp Toxicol 2002 ; 21: 675.
14. Kannan GM, Flora SJS. Chronic arsenic poisoining in the rat: treatment with combined administration of succimers and an antioxidant. Ecotoxicol Environ Saf 2004 ; 58: 37.
15. Bera AK, Rana T., Das S., Bandypadhyay S., et al. L-ascorbate protects arsenic induced oxidative damages and cytotoxicity in rat hepatocytes. Hum Exp Toxicol 2010 ; 29: 103-111.
16. Saha B. Effect of ascorbic acid on reduced glutathione level in arsenic-loaded isolated liver tissues of rat. Bangladesh J Pharmacol 2006 ; 1: 68.
17. Marklund S., Marklund G. Involvement of superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974 ; 47: 469.
18. Minami M., Yoshikawa H. Simplified assay method of superoxide dismutase activity of clinical use. Clin Chem Acta 1979 ; 92: 337.
19. Cohen G., Dembuic D., Marcus J. Measurement of catalase activity in tissue extract. Anal Biochem 1970 ; 34: 30.
20. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979 ; 95: 351.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ Protein measurement with the Folin phenol reagent. J Biol Chem 1951 ; 193: 265.
22. Utley HG, Bernheim F., Hochsein P. Effect of sulphydryl reagents on peroxidation of microsomes. Arch Biochem Biophys 1967 ; 118: 29.
23. Reznick A.Z., Packer L. Oxidative damage to proteins: spectrophotometric methods for carbonyl assay. Meth Enzymol 1994 ; 233: 357-363.
24. Czuprynski CJ, Henson PM, Campbell PA Killing of Listeria monocytogenes by inflammatory neutrophil and mononuclear phagocytes from immune and non immune mice. J Leukocyte Biol 1984 ; 35: 193-208.
25. Sengupta M., Bishayi B. Effect of lead and arsenic on murine mecrophage response. Drug Chem Toxicol 2002 ; 25: 459-472.
26. Nandi D., Patra RC, Swarup D. Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic induced oxidative stress and biochemical alterations in rats. Toxicol 2005 ; 211: 26.
27. Kaur H., Mishra D., Bhatnagar P., Kaushik P., Flora SJS. Co-administration of ±-lipoic acid and vitamin C protects liver and brain oxidative stress in mice exposed to arsenic contaminated water. Water Qual Exp Health 2009 ; 1: 135-144.
28. Ribiere C., Hininger I., Rouach, H., Nordmann R. Effects of chronic ethanol administration on free radical defenses in rat myocardium. Biochem Pharmacol 1992 ; 44: 1495-1500.
29. Maiti S., Chatterjee AK Differential response of cellular antioxidant mechanism of liver and kidney to arsenic exposure and its relation to dietary protein deficiency. Environ Toxicol Pharmacol 2000 ; 8: 227.
30. Pie J., Yamauchi H., Kumagai Y., Sun G., Yoshida Y., Aikawa H., et al. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environ Health Persp 2002 ; 110: 331.
31. Shi H., Shi X., Liu KJ Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem 2004 ; 255: 67-78.
32. Wang TS, Kuo CF, Jan KY, Huang H. Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species. J Cell Physiol 1996 ; 169: 256-268.
33. Kadirvel R., Sundaram K., Mani S., Samuel S., Elango N., Panneerselvam C. Supplementation of ascorbic acid and ±-tocopherol prevents arsenic-induced protein oxidation and DNA damage induced by arsenic in rats. Hum Exp Toxicol 2007 ; 26: 939-946.
34. Burton GW, Ingold KU Vitamin E: application of principles of physical organic chemistry to the exploration of its structure and function. Acc Chem Res 1986 ; 19: 194-201.
35. Flora SJS, Bhadauria S., Dhaked RK, Pant SC Arsenic-induced oxidative stress and the role of antioxidant supplementation during chelation: a review. J Environ Biol 2007 ; 28: 333-347.
36. Flora SJS, Mittal M., Mehta A. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Ind J Med Res 2008 ; 128: 501-523.
37. Nandi D., Patra RC, Swarup D. Oxidative stress indices and plasma biochemical parameters during oral exposure to arsenic in rats. Food Chem Toxicol 2006 ; 44: 1579.
38. Tabassum Noor-E. Effect of alpha-lipoic acid on the removal of arsenic from arsenic-loaded isolated liver tissues of rat. Bangladesh J Pharmacol 2006 ; 1: 27.
39. Ahmed F., Jalil MA, Ali MA, Hossain MD, Badruzzaman ABM. An overview of arsenic removal technologies in BUET, In: MF Ahmed (ed.) Bangladesh environment-2000. Bangladesh Poribesh Andolon, 2006, p. 177.
40. Ei-Demerdash FM, Yousef MI, Radwan FME. Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food Chem Toxicol 2009 ; 47: 249-254.
41. Sohini, Rana SVS. Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat. Indian J Exp Biol 2007 ; 45: 371.
42. Chattopadhyay S., Ghosh S., Debnath J., Ghosh D. Protection of sodium arsenite-induced ovarian toxicity by coadministration of L-ascorbate (vitamin C) in mature Wistar strain rat. Arch Environ Contam Toxicol 2001 ; 41: 83.
43. Stadtman ER, Berlett, BS Reactive oxygen-mediated protein oxidation in aging and disease. Chem Res Toxicol 1997 ; 10: 485-494.
44. Schmidt HH, Walter U. NO at work. Cell 1994 ; 78: 919-925.
45. Marletta MA Nitrite oxide synthase: aspects concerning structure and catalysis. Cell 1994 ; 78: 927-930.
46. Pi J., Horiguchi S., Sun Y., et al. A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenite in rabbits. Free Radic Biol Med 2003 ; 35: 102-113.
47. Kumagai Y., Pi J. Molecular basis for arsenic-induced alteration in nitric oxide production and oxidative stress: implication of endothelial dysfunction. Toxicol Appl Pharmacol 2004 ; 198: 450-457.
48. Gurr JR, Yih LH, Samikkannu T., Bau DT, Lin SY, Jan KY Nitric oxide production by arsenite. Mutat Res 2003 ; 533 (1-2). 173-182.
49. Mukherjee S., Das D., Darbar S., Mitra C. Dietary intervention affects arsenic-generated nitric oxide and reactive oxygen intermediate toxicity in islet cells of rats. Curr Sci 2003 ; 85: 786-793.
50. Rosen GM, Tsai P., Weaver J., et al. The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide. J Biol Chem 2002 ; 277: 40275-40280.
51. Xia Y., Tsai AL, Berka V., et al. Superoxide generation from endothelial nitric-oxide synthase. J Biol Chem 1998: 274: 25804-25808.
52. Santra A., Chowdhury A., Ghatak S., Biswas A., Dhali GK Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N-acetylcysteine. Toxicol Appl Pharmacol 2007 ; 220: 146-155.
53. Heller R., Munscher-Pailug F., Grabner R., Till U. L-ascorbic acid potentiates nitrite oxide synthesis in endothelial cells. J Biol Chem 1999 ; 274: 8254-8260.
54. Huang A., Vita JA, Venema RC, Keaney Jr JF Ascorbic acid enhances endothelial nitrite oxide synthase activity by increasing intra cellular tetrahydrobiopterin. J Biol Chem 2000 ; 275: 17399-17496.
55. Li X., Cobb CE, Hill KE, Burk RF, May JM Mitochondrial uptake and recycling of ascorbic acid. Arch Biochem Biophys 2001 ; 387: 143-153.