Supplementation of ascorbic acid and α-tocopherol prevents arsenic-induced protein oxidation and DNA damage induced by arsenic in rats

Human and Experimental Toxicology

Volumn 26, Issue 12, 2007, Pages 939-946

  Kadirvel, R ^a,b   Sundaram, K ^a,c   Mani, S ^a,c   Samuel, S ^b   Elango, N ^a   Panneerselvam, C ^a  

^a UNIVERSITY OF MADRAS   (India)

^b Mayo Clinic   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

antioxidants; arsenic; DNA damage; oxidative stress; protein oxidation

Indexed keywords

RATTUS;

ALPHA TOCOPHEROL; ARSENIC; ASCORBIC ACID; DNA; DRINKING WATER; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARSENIC POISONING; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; CROSS LINKING; DNA STRAND BREAKAGE; DRUG EFFECT; KIDNEY; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN METABOLISM; RAT; TREATMENT OUTCOME; WATER CONTAMINATION;

ADMINISTRATION, ORAL; ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; ARSENIC POISONING; ARSENITES; ASCORBIC ACID; COMET ASSAY; CROSS-LINKING REAGENTS; DISEASE MODELS, ANIMAL; DNA DAMAGE; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; KIDNEY; LIVER; MALE; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RATS; RATS, WISTAR; SODIUM COMPOUNDS; WATER SUPPLY;

EID: 43249107897     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327107087909     Document Type: Article

References (39)

1. Fishbein, L. Sources, transport and alterations of metal compounds: An overview. I. Arsenic, beryllium, cadmium, chromium, and nickel. Environ Health Perspect 1981; 40: 43-64.
2. USEPA. National primary drinking water regulations; arsenic and clarifications to compliance and new source contaminations monitoring. Fed Regist 2001; 66: 50961-50963.
3. Yoshida, T, Yamauchi, H, Fan Sun, G. Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol Appl Pharmacol 2004; 198: 243-252.
4. Chen, CJ, Hsu, LI, Wang, CH, Shih, WL, Hsu, YH, Tseng, MP, et al. Biomarkers of exposure, effect, and susceptibility of arsenic-induced health hazards in Taiwan. Toxicol Appl Pharmacol 2005; 206: 198-206.
5. Abernathy, CO, Thomas, DJ, Calderon, RL. Health effects and risk assessment of arsenic. J Nutr 2003; 133: 1536S-1538S.
6. Muckter, H, Liebl, B, Reichl, FX, Hunder, G, Walther, U, Fichtl, B. Are we ready to replace dimercaprol (BAL) as an arsenic antidote? Hum Exp Toxicol 1997; 16: 460-465.
7. Flora, SJ. Arsenic-induced oxidative stress and its reversibility following combined administration of Nacetylcysteine and meso 2,3-dimercaptosuccinic acid in rats. Clin Exp Pharmacol Physiol 1999; 26: 865-869.
8. Samuel, S, Samuel, S, Kathirvel, R, Jayavelu, T, Chinnakkannu, P. Protein oxidative damage in arsenic induced rat brain: influence of DL-alpha-lipoic acid. Toxicol Lett 2005; 155: 27-34.
9. Pi, J, Yamauchi, H, Kumagai, Y, Sun, G, Yoshida, T, Aikawa, H. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environ Health Perspect 2002; 110: 331-336.
10. Shi, H, Shi, X, Liu, KJ. Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem 2004; 255: 67-78.
11. Kitchin, KT, Ahmad, S. Oxidative stress as a possible mode of action for arsenic carcinogenesis. Toxicol Lett 2003; 137: 3-13.
12. Wu, MM, Chiou, HY, Wang, TW, Hsueh, YM, Wang, IH, Chen, CJ, et al. Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan. Environ Health Perspect 2001; 109: 1011-1017.
13. Das, S, Santra, A, Lahiri, S, Guha Mazumder, DN. Implications of oxidative stress and hepatic cytokine (TNF-alpha and IL-6) response in the pathogenesis of hepatic collagenesis in chronic arsenic toxicity. Toxicol Appl Pharmacol 2005; 204: 18-26.
14. Shi, H, Hudson, LG, Liu, KJ. Oxidative stress and apoptosis in metal ion-induced carcinogenesis. Free Radic Biol Med 2004; 37: 582-593.
15. Liu, SX, et al. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc Natl Acad Sci U S A 2001; 98: 1643-1648.
16. Arrigoni, O, De Tullio, MC. Ascorbic acid: much more than just an antioxidant. Biochim Biophys Acta 2002; 1569: 1-9.
17. Lee, BM, Lee, SK, Kim, HS. Inhibition of oxidative DNA damage, 8-OHdG, and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng). Cancer Lett 1998; 132: 219-227.
18. Ramanathan, K, Balakumar, BS, Panneerselvam, C. Effects of ascorbic acid and alpha-tocopherol on arsenic-induced oxidative stress. Hum Exp Toxicol 2002; 21: 675-680.
19. Ramanathan, K, Shila, S, Kumaran, S, Panneerselvam, C. Protective role of ascorbic acid and alphatocopherol on arsenic-induced microsomal dysfunctions. Hum Exp Toxicol 2003; 22: 129-136.
20. Ramanathan, K, Shila, S, Kumaran, S, Panneerselvam, C. Ascorbic acid and alpha-tocopherol as potent modulators on arsenic induced toxicity in mitochondria. J Nutr Biochem 2003; 14: 416-420.
21. Ramanathan, K, Anusuyadevi, M, Shila, S, Panneerselvam, C. Ascorbic acid and alpha-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats. Toxicol Lett 2005; 156: 297-306.
22. Lowry, OH, Rosebrough, NJ, Fan, AL, Randall, RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
23. Levine, RL, Garland, D, Oliver, CN, Amici, A, Climent, I, Lenz, AG. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990; 186: 464-478.
24. Dhawan, A, Mathur, N, Seth, PK. The effect of smoking and eating habits on DNA damage in Indian population as measured in the Comet assay. Mutat Res 2001; 474: 121-128.
25. Singh, NP, McCoy, MT, Tice, RR, Schneider, EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175: 184-191.
26. Zhitkovich, A, Costa, M. A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo. Carcinogenesis 1992; 13: 1485-1489.
27. Stadtman, ER, Berlett, BS. Reactive oxygen-mediated protein oxidation in aging and disease. Chem Res Toxicol 1997; 10: 485-494.
28. Stadtman, ER, Levine, RL. Protein oxidation. Ann N Y Acad Sci 2000; 899: 191-208.
29. Wang, TC, Jan, KY, Wang, AS, Gurr, JR. Trivalent arsenicals induce lipid peroxidation, protein carbonylation, and oxidative DNA damage in human urothelial cells. Mutat Res 2006; 615: 75-86.
30. Cao, G, Cutler, RG. Protein oxidation and aging. I. Difficulties in measuring reactive protein carbonyls in tissues using 2,4-dinitrophenylhydrazine. Arch Biochem Biophys 1995; 320: 106-114.
31. Thirunavukkarasu, C, Sakthisekaran, D. Sodium selenite, dietary micronutrient, prevents the lymphocyte DNA damage induced by N-nitrosodiethylamine and phenobarbital promoted experimental hepatocarcinogenesis. J Cell Biochem 2003; 88: 578-588.
32. Wei, M, Wanibuchi, H, Morirnura, K, Iwai, S, Yoshida, K, Endo, G. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis 2002; 23: 1387-1397.
33. Yamauchi, H, Aminaka, Y, Yoshida, K, Sun, G, Pi, J, Waalkes, MP. Evaluation of DNA damage in patients with arsenic poisoning: urinary 8-hydroxydeoxyguanine. Toxicol Appl Pharmacol 2004; 198: 291-296.
34. Minko, IG, Zou, Y, Lloyd, RS. Incision of DNA-protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair. Proc Natl Acad Sci U S A 2002; 99: 1905-1909.
35. Andrew, AS, Burgess, JL, Meza, MM, Demidenko, E, Waugh, MG, Hamilton, JW, et al. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ Health Perspect 2006; 114: 1193-1198.
36. Valko, M, Izakovic, M, Mazur M, Rhodes, CJ, Telser, J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 2004; 266: 37-56.
37. Duthie, SJ, Ma, A, Ross, MA, Collins, AR. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res 1996; 56: 1291-1295.
38. Cadenas, S, Baja, G, Poulsen, HE, Loft, S. Oxidative DNA damage estimated by oxo8dG in the liver of guinea-pigs supplemented with graded dietary doses of ascorbic acid and alpha-tocopherol. Carcinogenesis 1997; 18: 2373-2377.
39. Chaudiere, J, Ferrari-Iliou, R. Intracellular antioxidants: from chemical to biochemical mechanisms. Food Chem Toxicol 1999; 37: 949-962.