Protective value of Aloe vera against some toxic effects of arsenic in rats

Phytotherapy Research

Volumn 19, Issue 1, 2005, Pages 23-28

  Gupta, Richa ^a   Flora, Swaran J S ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Aloe vera; Haematological and hepatic effects; Protection against arsenic exposure: oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALOE VERA EXTRACT; ARSENIC; ASPARTATE AMINOTRANSFERASE; CATALASE; DRINKING WATER; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEMOGLOBIN; PROTOPORPHYRIN ZINC; SUPEROXIDE DISMUTASE;

ALOE VERA; ANIMAL CELL; ANIMAL EXPERIMENT; ARSENIC POISONING; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN DETERMINATION; LEUKOCYTE COUNT; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; NONHUMAN; OXIDATIVE STRESS; PROTEIN CONTENT; RAT; THROMBOCYTE COUNT;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ALOE; ANIMALS; ARSENIC; ARSENIC POISONING; ASPARTATE AMINOTRANSFERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATITIS, TOXIC; INJECTIONS, INTRAPERITONEAL; LEUKOCYTE COUNT; LIVER; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ALOE VERA; ANIMALIA;

EID: 15944423569     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1560     Document Type: Article

References (33)

1. Aebi, H. 1984. Catalase. In Methods in Enzymol, Packer L (ed.). Academic Press: Orlando, FL; 125-126.
2. Agency for Toxic substances and Disease Registry (ATSDR). 1993. Toxicological Profile for Arsenic. US Public Health Service, Atlanta, GA.
3. Berlin A, Schaller KH. 1974, European standardized method for the determination of delta aminolevulinic acid dehydratase activity in blood. Zeit Klin Chem Klin Biochem 12: 389-390.
4. Blythe D, Joyce DA. 2001. Clearance of arsenic by haemodialysis after acute poisoning with arsenic trioxide. Intensive Care Med 27: 334.
5. Chiou HY, Hsueh YM, Liaw KF, et al. 1995. Incidence of internal cancer and ingested inorganic arsenic: a seven-year follow-up study in Taiwan. Cancer Res 55: 1296-1300.
6. Chiou HY, Huang WI, Su CL, et al. 1997. Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke 28: 1717-1723.
7. Chithra P, Sajithlal GB, Chandrakasan G. 1998. Influence of Aloe vera on the glycosaminiglycans in the matrix of healing dermal wounds in rats. J Ethanopharmacol 59: 179-186.
8. Dong HQ, Wang KL, Ma YJ. 1993. A clinical analysis of 117 cases of acute arsenic poisoning. Zhonghua Nei Ke Za Zhi 32: 813-815.
9. Durak I, Canbolat O, Kavutch M, et al. 1996. Activities of total, cytoplasmic and mitochondrial superoxide dismutase enzymes in sera and plural fluids from patients with lung cancer. J Clin Lab Anal 10: 17-20.
10. Ellman GL. 1959. Tissue sulfhydryl groups. Arch Biochem 82: 70-77.
11. Flora SJS. 1999. Arsenic induced oxidative stress and its reversibility following combined administration of N-acetyl cysteine and meso 2,3-dimercaptosuccinic acid in rats. Clin Exp Pharmacol Physiol 26: 865-869.
12. Flora SJS. 2000. Possible health hazards associated with the use of toxic metals in semiconductor industries. J Occup Health 42: 105-110.
13. Grandjean P. 1979. Occupational lead exposure in Denmark: screening with a haematofluorimeter. Br J Indust Med 36: 52-58.
14. Grindlay G, Reynolds T. 1986. The Aloe vera phenomenon. A review of the properties and modern uses of the leaf parenchyma gel. J Ethnopharmacology 16: 117-151
15. Halk PB, Oser BL, Summerson WH. 1954. Practical Physiology Chemistry. McGraw Hill: New York.
16. Herlihy JT, Bertrand HA, Kim JD, et al. 1998. Effects of Aloe vera ingestion in the rat!. Growth, food and fluid intake and serum chemistry. Phytothepray Res 12: 183-188.
17. Hissin PJ, Hilf R. 1973. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74: 214-226.
18. Jolliffe DM, Budd AJ, Gwit DJ. 1991. Massive acute arsenic poisoning. Anesthesia 46: 288-299.
19. Kannan GM, Flora SJS. 2003. Chronic arsenic poisoning in rat: treatment with combined administration of succimers and an antioxidant. Ecotoxicol Environ Safety, in Press.
20. Kannan GM, Tripathi N, Dube SN, et al. 2001. Toxic effects of arsenic (III) on some hematopoietic and central nervous system variables in rats and guinea pigs. Clin Toxicol 39: 675-682.
21. Maiti S, Chatterjee AK. 2000. Differential response of cellular antioxidant mechanism of liver and kidney to arsenic exposure and its relation to dietary protein deficiency. Environ Toxicol Pharmacol 8: 227-235.
22. Maiti S, Chatterjee AK. 2001. Effects on levels of gluathione and some related enzymes in tissues after an acute arsenic exposure ad their relationship to dietary protein deficiency. Arch Toxicol 75: 531-537.
23. Mehta A, Flora SJS. 2001. Possible role of metal redistribution, hepatotoxicity and oxidative stress in chelating agents induced hepatic and renal metallothionein in rats. Fd Chem Toxicol 39: 1029-1038.
24. Moore DF, O'Callaghan CA, Berlyne G, et al. 1994. Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3- dimercaptopropanesulphonate (DMPS). J Neurol Neurosurg Psychiatry 57: 1133-1135.
25. Nandi P, Talukder G, Sharma A. 1997. Dietary factors in cancer chemoprevention. The Nucleus 40: 128-144s
26. Neiger RD, Osweiler GD. 1989. Effect of sub acute low-level dietary sodium arsenite on dogs. Fund Appl Toxicol 13: 439-451.
27. Ramos O, Carrizales L, Yanez L, et al. 1995. Arsenic increased lipid peroxidation in rat tissues by a mechanism independent of Glutathione levels. Environ Health Perspect 103 (Suppl 1): 85-88.
28. Reynolds T, Dweck AC. 1999. Aloe vera leaf gel: a review update. J Ethanopharmacol 68: 3-37.
29. Reitman S, Frankel S. 1957. A calorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28: 56-63.
30. Waalkes MP. 1995. Target sites of carcinogenic metals. In Metal Toxicology, Goyer RA, Klaassen CD, Waalkes MP (eds). Academic Press: New York; 54-56.
31. Wax PM, Thornton CA. 2000. Recovery from severe arsenic induced peripheral neuropathy with 2,3-dimercapto-1-propane-sulphonic acid. J Toxicol Clin Toxicol 38: 777-780.
32. Wilber KM, Baerheim F, Shapiro OW. 1949. The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acid by various reagent. Arch Biochem Biphys 24: 304-311.
33. Yagi A, Kabash YA, Okamura N, et al. 2002. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Planta Medica 68: 957-960.