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Since the Tester sidechain that is attached to the monomer in the adjacent loop would obstruct the ability of the dia-mine crosslinker to reach to the aldehyde handle, it was deleted from the sequence by using monomer 12b
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Since the Tester sidechain that is attached to the monomer in the adjacent loop would obstruct the ability of the dia-mine crosslinker to reach to the aldehyde handle, it was deleted from the sequence by using monomer 12b.
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32
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77958546136
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During the initial studies, oligomer 1 contained trimethyl-silyl acetylene end groups as an artifact of the solid-phase synthesis (see Ref. 29), resulting in the different m/z ratios observed in Figure 3 in comparison with the crosslinked oligomer used in the more detailed studies later on. These were later deleted from the sequence for convenience. These end groups do not have a measurable effect on the folding capability of the oligomer and their absence or presence does not affect the crosslinking reaction.
-
During the initial studies, oligomer 1 contained trimethyl-silyl acetylene end groups as an artifact of the solid-phase synthesis (see Ref. 29), resulting in the different m/z ratios observed in Figure 3 in comparison with the crosslinked oligomer used in the more detailed studies later on. These were later deleted from the sequence for convenience. These end groups do not have a measurable effect on the folding capability of the oligomer and their absence or presence does not affect the crosslinking reaction.
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