Synthesis of C-4 and C-7 triazole analogs of zanamivir as multivalent sialic acid containing scaffolds

Carbohydrate Research

Volumn 342, Issue 12-13, 2007, Pages 1636-1650

  Lu, Yan ^a   Gervay Hague, Jacquelyn ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

C 4 Analog; C 7 Analog; Click; Zanamivir

Indexed keywords

AZIDES; C-4 ANALOG; C-7 ANALOG; ZANAMIVIR;

AMINO ACIDS; CATALYST ACTIVITY; CYCLOADDITION; HYDROCARBONS;

ENZYME INHIBITION;

2 [2 (2 AZIDOETHOXY)ETHOXY]ETHYLAMINE; 2,4,6 TRIS 2 YLOXYMETHYL [5 ACETYLAMINO 6 (1,2,3 TRIACETOXYPROPYL) 4 [1,2,3] 2 YLOXYMETHYL 1 YL 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER][1,3,5]BENZENE; 2,4,6 TRIS 2 YLOXYMETHYL [5 ACETYLAMINO 6 (1,2,3 TRIACETOXYPROPYL) 4 [1,2,3] 2 YLOXYMETHYL 1 YL 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER][1,3,5]TRIAZINE; 2,4,6 TRIS 2 YLOXYMETHYL [5 ACETYLAMINO 6 (1,2,3 TRIHYDROXYPROPYL) 2 YLOXYMETHYL 1 YL 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID][1,3,5]BENZENE; 2,4,6 TRIS 2 YLOXYMETHYL [5 ACETYLAMINO 6 (1,2,3 TRIHYDROXYPROPYL) 2 YLOXYMETHYL 1 YL 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID][1,3,5]TRIAZINE; 5 ACETYLAMINO 4 (4 AMINOETHYL[1,2,3]TRIAZOL 1 YL) 6 (1,2,3 TRIHYDROXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID; 5 ACETYLAMINO 4 (4 BENZOYLAMINOCARBONYL[1,2,3]TRIAZOL 1 YL) 6 (1,2,3 TRIACETOXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER; 5 ACETYLAMINO 4 (4 BENZYLCARBAMOYL[1,2,3]TRIAZOL 1 YL) 6 (1,2,3 TRIHYDROXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID; 5 ACETYLAMINO 4 (4 DIETHOXYMETHYL[1,2,3]TRIAZOL 1 YL) 6 (1,2,3 TRIACETOXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER; 5 ACETYLAMINO 4 (4 FORMYL[1,2,3]TRIAZOL 1 YL) 6 (1,2,3 TRIHYDROXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID; 5 ACETYLAMINO 4 (4 PROPYL[1,2,3]TRIAZOL 1 YL) 6 (1,2,3 TRIACETOXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER; 5 ACETYLAMINO 4 (4 PROPYL[1,2,3]TRIAZOL 1 YL) 6 (1,2,3 TRIHYDROXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID; 5 ACETYLAMINO 4 [4 (1 HYDROXY 1 METHYL ETHYL)[1,2,3]TRIAZOL 1 YL] 6 (1,2,3 TRIACETOXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER; 5 ACETYLAMINO 4 [4 (1 HYDROXY 1 METHYLETHYL)[1,2,3]TRIAZOL 1 YL] 6 (1,2,3 TRIHYDROXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID; 5 ACETYLAMINO 4 [4 (3 CHLOROPROPYL)[1,2,3]TRIAZOL 1 YL] 6 (1,2,3 TRIACETOXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER; 5 ACETYLAMINO 4 [4 (3 CHLOROPROPYL)[1,2,3]TRIAZOL 1 YL] 6 (1,2,3 TRIHYDROXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID; 5 ACETYLAMINO 4 [4 (3 HYDROXYPROPYL)[1,2,3]TRIAZOL 1 YL] 6 (1,2,3 TRIACETOXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER; 5 ACETYLAMINO 4 [4 (3 HYDROXYPROPYL)[1,2,3]TRIAZOL 1 YL] 6 (1,2,3 TRIHYDROXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID; 5 ACETYLAMINO 4 [4 [(9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)METHYL][1,2,3]TRIAZOL 1 YL] 6 (1,2,3 TRIACETOXYPROPYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER; 5 ACETYLAMINO 6 [[2 [2 (2 AZIDOETHOXY)ETHOXY]ETHYLCARBAMOYLOXY](2,2 DIMETHYL[1,3]DIOXOLAN 4 YL)METHYL] 4 (2 TERT BUTOXYCARBONYLAMINO 2 TERT BUTOXYCARBONYLIMINO ETHYL) 5,6 DIHYDRO 4H PYRAN 2 CARBOXYLIC ACID METHYL ESTER; SCAFFOLD PROTEIN; SIALIC ACID; TRIAZINE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ZANAMIVIR;

ARTICLE; CATALYST; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; CARBOHYDRATE CONFORMATION; ENZYME INHIBITORS; GUANIDINES; INDICATORS AND REAGENTS; MODELS, MOLECULAR; SIALIC ACIDS; TRIAZOLES; ZANAMIVIR;

EID: 34447307403     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2007.06.002     Document Type: Article

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