Activation and potentiation of human GABAA receptors by non-dioxin-like PCBs depends on chlorination pattern

Toxicological Sciences

Volumn 118, Issue 1, 2010, Pages 183-190

  Antunes Fernandes, Elsa C ^a   Hendriks, Hester S ^a   van kleef, Regina G D M ^a   Reniers, Ad ^a   Andersson, Patrik L ^b   van den berg, Martin ^a   Westerink, Remco H S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Binary mixture; Human GABAA receptor; Human risk assessment; Non dioxin like PCB; Receptor activation and potentiation; Structure activity relationship

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CHLORINE; DIOXIN; NON DIOXIN LIKE POLYCHLORINATED BIPHENYL; PHENYL GROUP; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATOM; BRAIN DEVELOPMENT; CHLORINATION; CONTROLLED STUDY; ELECTRODE; ENVIRONMENT; FEMALE; LEARNING; LONG TERM POTENTIATION; MEMORY; MOTOR COORDINATION; NONHUMAN; OOCYTE; PROTEIN ANALYSIS; RECEPTOR OCCUPANCY; SIGNAL TRANSDUCTION; SYNAPTIC POTENTIAL; VOLTAGE CLAMP; XENOPUS;

ANIMALS; CHLORINE; ENVIRONMENTAL POLLUTANTS; FEMALE; GABA-A RECEPTOR AGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; OOCYTES; PATCH-CLAMP TECHNIQUES; POLYCHLORINATED BIPHENYLS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 77958490961     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq257     Document Type: Article

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