Disruption of inositol phosphate accumulation in cerebellar granule cells by polychlorinated biphenyls: A consequence of altered Ca2+ homeostasis

Toxicology and Applied Pharmacology

Volumn 141, Issue 2, 1996, Pages 448-455

  Shafer, Timothy J ^a,b   Mundy, William R ^a   Tilson, Hugh A ^a   Kodavanti, Prasada Rao S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISINDOLYLMALEIMIDE; CARBACHOL; DIMETHYL SULFOXIDE; INOSITOL PHOSPHATE; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; POLYCHLORINATED BIPHENYL; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVATION; GRANULE CELL; NONHUMAN;

EID: 0030445698     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0311     Document Type: Article

References (45)

1. Atchison, W. D., and Hare, M. F. (1994). Mechanisms of methylmercury-induced neurotoxicity. FASEB J. 8, 622-629.
2. Banno, Y., Nakashima, S., and Nozawa, Y. (1986). Partial purification of phosphoinositide phospholipase C from human platelet cytosol: Characterization of its three forms. Biochem. Biophys. Res. Commun. 136, 713-721.
3. Berridge, M. J., Downes, C. P., and Handey, M. R. (1982). Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem. J. 206, 587-595.
4. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Brown, A. P., and Ganey, P. E. (1995). Neutrophil degranulation and superoxide production induced by polychlorinated biphenyls are calcium dependent. Toxicol. Appl. Phartnacol. 131, 198-205.
6. Cioffi, C. L., and Fisher, S. K. (1990). Reduction of muscarinic receptor density and of guanine-nucleotide stimulated phosphoinositide hydrolysis in human SH-SY-5Y neuroblastoma cells following long-term treatment with 12-O-tetradecanoylphorbol-13-acetate or mezerein. J. Neurochem. 54, 1725-1734.
7. Cockroft, S., and Thomas, G. M. H. (1992). Inositol-lipid-specific phospholipase C isozymes and their differential regulation by receptors. Biochem. J. 288, 1-14.
8. Costa, L. G. (1990). The phosphoinositide/protein kinase C system as a potential target for neurotoxicity. Pharmacol. Res. 22, 393-408.
9. Costa, L. G. (1994). Second messenger systems in developmental neurotoxicity. In Developmental Neurotoxicology (G. J. Harry, Ed.), pp. 77-101. CRC Press, Boca Raton, FL.
10. Davis, P. D., Elliott, L. H., Harris, W., Hill, C. H., Hurst, S. A., Keech, E., Kumar, M. K., Lawton, G., Nixon, J. S., and Wilkinson, S. E. (1992). Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity. J. Med. Chem. 36, 994-1001.
11. del Río, E., Nicholls, D. G., and Downes, C. P. (1994). Involvement of calcium influx in muscarinic cholinergic regulation of phospholipase C in cerebellar granule cells. J. Neurochem. 63, 535-543.
12. Fabiato, A. (1988). Computer programs for calculating total from specific free or free from specific total ionic concentrations in aqueous solutions containing multiple metals and ligands. Methods Enzymol. 157, 378-417.
13. Fein, G. G., Jacobson, M. S., Lilis, R., Thornton, J., and Selikoff, I. J. (1984). Prenatal exposure to polychlorinated biphenyls: Effects on birth size and gestational age. J. Pediatr. 105, 315-320.
14. Fisher, S. K., Heacock, A. M., and Agranoff, B. W. (1992). Inositol lipids and signal transduction in the nervous system: An update. J. Neurochem. 58, 18-38.
15. Gallo, V., Kingsbury, A., Balazs, R., and Jergensen, O. S. (1987). The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7, 2203-2213.
16. 3H]5-hydroxytryptamine in the spinal cord of the rat: The role of the L-type voltage-dependent calcium channels. Neuropharmacology 31, 1101-1109.
17. Gladen, B. C., and Rogan, W. J. (1991). Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development. J. Pediatr. 119, 58-63.
18. Gladen, B. C., Rogan, W. J., Hardy, P., Thullen, J., Tingelstad, J., and Tully, M. (1988). Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through breast milk. J. Pediatr. 113, 991-995.
19. Govoni, S., Lucchi, L., Battaini, F., and Trabucchi, M. (1992). Protein kinase C increase in rat brain cortical membranes may be promoted by cognition enhancing drugs. Life Sci. 5, PL125-PL128.
20. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3340-3350.
21. Hsu, S-T., Ma, C-I., Hsu, SK-H., Wu, S-S., Hsu, NH-M., and Yeh, C-C. (1985). Discovery and epidemiology of PCB poisoning in Taiwan: A four year follow-up. Environ. Health Perspect. 59, 5-10.
22. Kodavanti, P. R. S., Shin, D., Tilson, H. A., and Harry, G. J. (1993). Comparative effects of two polychlorinated biphenyl congeners on calcium homeostasis in rat cerebellar granule cells. Toxicol. Appl. Pharmacol. 123, 97-106.
23. Kodavanti, P. R. S., Shafer, T. J., Ward, T. R., Mundy, W. R., Freudenrich, T., Harry, G. J., and Tilson, H. A. (1994). Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells. Brain Res. 662, 75-82.
24. 3H]phorbol ester binding in rat cerebellar granule cells by polychlorinated biphenyl mixtures and congeners: Structure-activity relationships. Toxicol. Appl. Pharmacol. 130, 140-148.
25. 2+-sequestration in rat cerebellum by polychlorinated diphenyl ether congeners and analogs: Structure-activity relationships. Toxicol. Appl. Pharmacol. 138, 251-261.
26. 2+-sequestration in rat cerebellum by polychlorinated biphenyl mixtures and congeners: Structure-activity relationships. Arch. Toxicol. 70, 150-157.
27. Kuratsune, M. (1989). Yusho, with reference to Yu-Cheng. In Halogenated Biphenyls, Terphenyls, Naphthalenes Dibenzodioxins, and Related Products (R. D. Kimbrough and K. F. Jensen, Eds.), 2nd ed., pp. 381-400. Elsevier, Amsterdam.
28. Lin, W-W., Lee, C. Y., Yasumoto, T., and Chuang, D-M. (1990). Maitotoxin induces phosphoinositide turnover and modulates glutamatergic and muscarinic cholinergic receptor function in cultured cerebellar neurons. J. Neurochem. 55, 1563-1568.
29. Malkinson, A. M., Conway, K., Bartlett, S., Butley, M. S., and Conroy, C. (1984). Strain differences among inbred strains of mice in protein kinase C activity. Biochem. Biophys. Res. Commun. 122, 492-498.
30. Orellana, S., Solski, P. A., and Brown, J. H. (1987). Guanosine 5′-O-(thiotriphosphate)-dependent inositol phosphate formation in membranes is inhibited by phorbol ester and protein kinase C. J. Biol. Chem. 262, 1638-1643.
31. Pearce, B., Morrow, C., and Murphy, S. (1988). Characteristics of phorbol ester and agonist-induced down regulation of astrocyte receptors coupled to inositol phospholipid metabolism. J. Neurochem. 50, 936-944.
32. Rogan, W. J., and Gladen, B. C. (1992). Neurotoxicity of PCBs and related compounds. Neurotoxicology 13, 27-36.
33. Safe, S. H. (1994). Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses and implications for risk assessment. Crit. Rev. Toxicol. 24, 87-149.
34. 2+ and inositol phosphate levels in cultured cerebellar granule neurons. J. Neurochem. 61, 648-657.
35. Seegal, R. F., and Schantz, S. L. (1994). Neurochemical and behavioral sequelae of exposure to dioxins and PCBs. In Dioxins and Health (A. Schecter, Ed.), pp. 409-447. Plenum, New York.
36. Seegal, R. F., Bush, B., and Brosch, K. O. (1991a). Sub-chronic exposure of the rat to Aroclor 1254 selectively alters dopaminergic function. Neurotoxicology 12, 55-66.
37. Seegal, R. F., Bush, B., and Brosch, K. O. (1991b). Comparison of effects of Aroclors 1016 and 1260 on nonhuman primate catecholamine functions. Toxicology 66, 145-163.
38. Shain, W., Bush, B., and Seegal, R. (1991). Neurotoxicity of polychlorinated biphenyls: Structure-activity relationship of individual congeners. Toxicol. Appl. Pharmacol. 111, 33-42.
39. 2+], and their determination using fluorescent probes. J. Biol. Chem. 266, 1410-1414.
40. Tilson, H. A., Jacobson, J. L., and Rogan, W. J. (1990). Polychlorinated biphenyls and the developing nervous system: Cross-species comparisons. Neurotoxicol. Teratol. 12, 239-248.
41. Tilson, H. A., and Kodavanti, P. R. S. (1996). Neurochemical effects of polychlorinated biphenyls: An overview and identification of research needs. Neurotoxicology, in press.
42. Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., Lorilolle, F., Duhamel, L., Charon, D., and Kirilovsky, J. (1991). The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266, 15771-15781.
43. Vignes, M., Guiramand, J., Sassetti, I., and Récasens, M. (1993). Effect of thiol reagents on phosphoinositide hydrolysis in rat brain synaptoneurosomes. Eur. J. Neurosci. 5, 327-334.
44. Wigginton, S. A., and Minneman, K. P. (1991). Comparison of calcium ionophore and receptor-activated inositol phosphate formation in primary glial cell cultures. Eur. J. Pharmacol. 208, 239-247.
45. Wong, P. W., Buck, E. D., and Pessah, I. N. (1995). Ortho-substituted polychlorinated biphenyls (PCBs) activate ryanodine receptor type I in cerebellum and skeletal muscle. Toxicologist 15, 189.