HTLV-I p30: A versatile protein modulating virus replication and pathogenesis

Molecular Aspects of Medicine

Volumn 31, Issue 5, 2010, Pages 344-349

  Bai, Xue Tao ^a   Baydoun, Hicham Hachem ^a   Nicot, Christophe ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

HTLV I; Leukemia; P30; Pathogenesis; Viral latency

Indexed keywords

PROTEIN P30; REX PROTEIN;

ADAPTIVE IMMUNITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOMODULATION; INNATE IMMUNITY; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; T CELL LEUKEMIA; VIRUS IMMUNITY; VIRUS LATENCY; VIRUS PATHOGENESIS; VIRUS REPLICATION;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL NUCLEUS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; IMMUNITY, INNATE; LEUKEMIA; TRANSCRIPTION, GENETIC; VIRAL PROTEINS; VIRUS REPLICATION;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 77958466114     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mam.2010.05.004     Document Type: Review

References (26)

1. Albrecht B., Lairmore M.D. Critical role of human T-lymphotropic virus type 1 accessory proteins in viral replication and pathogenesis. Microbiol. Mol. Biol. Rev. 2002, 66:396-406. table.
2. Awasthi S., Sharma A., Wong K., Zhang J., Matlock E.F., Rogers L., Motloch P., Takemoto S., Taguchi H., Cole M.D., Luscher B., Dittrich O., Tagami H., Nakatani Y., McGee M., Girard A.M., Gaughan L., Robson C.N., Monnat R.J., Harrod R. A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions. Mol. Cell Biol. 2005, 25:6178-6198.
3. Bellon M., Lepelletier Y., Hermine O., Nicot C. Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia. Blood 2009, 113:4914-4917.
4. Ciminale V., Pavlakis G.N., Derse D., Cunningham C.P., Felber B.K. Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I. J. Virol. 1992, 66:1737-1745.
5. D'Agostino D.M., Silic-Benussi M., Hiraragi H., Lairmore M.D., Ciminale V. The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth. Cell Death Differ. 2005, 12(Suppl. 1):905-915.
6. Datta A., Sinha-Datta U., Dhillon N.K., Buch S., Nicot C. The HTLV-I p30 interferes with TLR4 signaling and modulates the release of pro- and anti-inflammatory cytokines from human macrophages. J. Biol. Chem. 2006, 281:23414-23424.
7. Datta A., Silverman L., Phipps A.J., Hiraragi H., Ratner L., Lairmore M.D. Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survival. Retrovirology 2007, 4:49.
8. Derse D., Mikovits J., Ruscetti F. X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro. Virology 1997, 237:123-128.
9. Feuer G., Fraser J.K., Zack J.A., Lee F., Feuer R., Chen I.S. Human T-cell leukemia virus infection of human hematopoietic progenitor cells: maintenance of virus infection during differentiation in vitro and in vivo. J. Virol. 1996, 70:4038-4044.
10. Ghorbel S., Sinha-Datta U., Dundr M., Brown M., Franchini G., Nicot C. Human T-cell leukemia virus type I p30 nuclear/nucleolar retention is mediated through interactions with RNA and a constituent of the 60 S ribosomal subunit. J. Biol. Chem. 2006, 281:37150-37158.
11. Koralnik I.J., Gessain A., Klotman M.E., Lo M.A., Berneman Z.N., Franchini G. Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I. Proc. Natl. Acad. Sci. USA 1992, 89:8813-8817.
12. Koralnik I.J., Fullen J., Franchini G. The p12I, p13II, and p30II proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments. J. Virol. 1993, 67:2360-2366.
13. Lairmore M.D., Albrecht B., D'Souza C., Nisbet J.W., Ding W., Bartoe J.T., Green P.L., Zhang W. In vitro and in vivo functional analysis of human T cell lymphotropic virus type 1 pX open reading frames I and II. AIDS Res. Hum. Retroviruses 2000, 16:1757-1764.
14. Michael B., Nair A.M., Hiraragi H., Shen L., Feuer G., Boris-Lawrie K., Lairmore M.D. Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytes. Retrovirology 2004, 1:39.
15. Michael B., Nair A.M., Datta A., Hiraragi H., Ratner L., Lairmore M.D. Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity. Virology 2006, 354:225-239.
16. Nicot C., Dundr M., Johnson J.M., Fullen J.R., Alonzo N., Fukumoto R., Princler G.L., Derse D., Misteli T., Franchini G. HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication. Nat. Med. 2004, 10:197-201.
17. Nicot C., Harrod R.L., Ciminale V., Franchini G. Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions. Oncogene 2005, 24:6026-6034.
18. Pique C., Dokhelar M.C. In vivo production of Rof and Tof proteins of HTLV type 1: evidence from cytotoxic T lymphocytes. AIDS Res. Hum. Retroviruses 2000, 16:1783-1786.
19. Pique C., Ureta-Vidal A., Gessain A., Chancerel B., Gout O., Tamouza R., Agis F., Dokhelar M.C. Evidence for the chronic in vivo production of human T cell leukemia virus type I Rof and Tof proteins from cytotoxic T lymphocytes directed against viral peptides. J. Exp. Med. 2000, 191:567-572.
20. Robek M.D., Wong F.H., Ratner L. Human T-cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes. J. Virol. 1998, 72:4458-4462.
21. Rosenbauer F., Owens B.M., Yu L., Tumang J.R., Steidl U., Kutok J.L., Clayton L.K., Wagner K., Scheller M., Iwasaki H., Liu C., Hackanson B., Akashi K., Leutz A., Rothstein T.L., Plass C., Tenen D.G. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Nat. Genet. 2006, 38:27-37.
22. Sinha-Datta U., Datta A., Ghorbel S., Dodon M.D., Nicot C. Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication. J. Biol. Chem. 2007, 282:14608-14615.
23. Taylor J.M., Ghorbel S., Nicot C. Genome wide analysis of human genes transcriptionally and post-transcriptionally regulated by the HTLV-I protein p30. BMC Genomics 2009, 10:311.
24. Yamamoto B., Li M., Kesic M., Younis I., Lairmore M.D., Green P.L. Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo. Retrovirology 2008, 5:38.
25. Younis I., Khair L., Dundr M., Lairmore M.D., Franchini G., Green P.L. Repression of human T-cell leukemia virus type 1 and type 2 replication by a viral mRNA-encoded posttranscriptional regulator. J. Virol. 2004, 78:11077-11083.
26. Zhang W., Nisbet J.W., Albrecht B., Ding W., Kashanchi F., Bartoe J.T., Lairmore M.D. Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300. J. Virol. 2001, 75:9885-9895.