Cytoplasmic viral replication complexes

Cell Host and Microbe

Volumn 8, Issue 1, 2010, Pages 77-85

  Den Boon, Johan A ^a   Diaz, Arturo ^a   Ahlquist, Paul ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA;

CELL ORGANELLE; CYTOPLASM; DNA VIRUS; HOST RESISTANCE; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA REPLICATION; RNA VIRUS; VIRUS ASSEMBLY; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS RELEASE; VIRUS REPLICATION; VIRUS TRANSCRIPTION; ANIMAL; GENETICS; PHYSIOLOGY; VIRAL PHENOMENA AND FUNCTIONS; VIRION; VIROLOGY; VIRUS; VIRUS INFECTION;

DNA VIRUSES; RNA VIRUSES;

ANIMALS; CYTOPLASM; HUMANS; VIRION; VIRUS DISEASES; VIRUS PHYSIOLOGICAL PHENOMENA; VIRUS REPLICATION; VIRUSES;

EID: 77958176122     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2010.06.010     Document Type: Review

References (103)

1. Ahlquist, P. (2006). Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses. Nat. Rev. Microbiol. 4, 371-382. (Pubitemid 43771855)
2. Ahola, T., and Ahlquist, P. (1999). Putative RNA capping activities encoded by brome mosaic virus: methylation and covalent binding of guanylate by replicase protein 1a. J. Virol. 73, 10061-10069.
3. Ahola, T., den Boon, J.A., and Ahlquist, P. (2000). Helicase and capping enzyme active site mutations in brome mosaic virus protein 1a cause defects in template recruitment, negative-strand RNA synthesis, and viral RNA capping. J. Virol. 74, 8803-8811.
4. Annamalai, P., and Rao, A.L. (2005). Replication-independent expression of genome components and capsid protein of brome mosaic virus in planta: a functional role for viral replicase in RNA packaging. Virology 338, 96-111. (Pubitemid 40838635)
5. Annamalai, P., and Rao, A.L. (2006). Packaging of brome mosaic virus subgenomic RNA is functionally coupled to replication-dependent transcription and translation of coat protein. J. Virol. 80, 10096-10108. (Pubitemid 44522603)
6. Arnold, M.M., Murray, K.E., and Nibert, M.L. (2008). Formation of the factory matrix is an important, though not a sufficient function of nonstructural protein mu NS during reovirus infection. Virology 375, 412-423.
7. Bartenschlager, R., and Miller, S. (2008). Molecular aspects of Dengue virus replication. Future Microbiol. 3, 155-165. (Pubitemid 351984064)
8. Baumstark, T., and Ahlquist, P. (2001). The brome mosaic virus RNA3 intergenic replication enhancer folds to mimic a tRNA TpsiC-stem loop and is modified in vivo. RNA 7, 1652-1670. (Pubitemid 33078939)
9. Belov, G.A., Habbersett, C., Franco, D., and Ehrenfeld, E. (2007). Activation of cellular Arf GTPases by poliovirus protein 3CD correlates with virus replication. J. Virol. 81, 9259-9267. (Pubitemid 47311468)
10. Bieniasz, P.D. (2009). The cell biology of HIV-1 virion genesis. Cell Host Microbe 5, 550-558.
11. Bienz, K., Egger, D., Rasser, Y., and Bossart, W. (1983). Intracellular distribution of poliovirus proteins and the induction of virus-specific cytoplasmic structures. Virology 131, 39-48. (Pubitemid 14248596)
12. Bienz, K., Egger, D., and Pasamontes, L. (1987). Association of polioviral proteins of the P2 genomic region with the viral replication complex and virus-induced membrane synthesis as visualized by electron microscopic immunocytochemistry and autoradiography. Virology 160, 220-226.
13. Bienz, K., Egger, D., Troxler, M., and Pasamontes, L. (1990). Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region. J. Virol. 64, 1156-1163. (Pubitemid 20087753)
14. Chen, J., and Ahlquist, P. (2000). Brome mosaic virus polymerase-like protein 2a is directed to the endoplasmic reticulum by helicase-like viral protein 1a. J. Virol. 74, 4310-4318. (Pubitemid 30214439)
15. Chen, J., Noueiry, A., and Ahlquist, P. (2001). Brome mosaic virus Protein 1a recruits viral RNA2 to RNA replication through a 50 proximal RNA2 signal. J. Virol. 75, 3207-3219. (Pubitemid 32225884)
16. Cho, M.W., Teterina, N., Egger, D., Bienz, K., and Ehrenfeld, E. (1994). Membrane rearrangement and vesicle induction by recombinant poliovirus 2C and 2BC in human cells. Virology 202, 129-145. (Pubitemid 24241985)
17. Delelis, O., Lehmann-Che, J., and Saïb, A. (2004). Foamy viruses-a world apart. Curr. Opin. Microbiol. 7, 400-406.
18. den Boon, J.A., Chen, J., and Ahlquist, P. (2001). Identification of sequences in Brome mosaic virus replicase protein 1a that mediate association with endoplasmic reticulum membranes. J. Virol. 75, 12370-12381. (Pubitemid 33115909)
19. Denison, M.R. (2008). Seeking membranes: positive-strand RNA virus replication complexes. PLoS Biol. 6, e270.
20. Dreux, M., and Chisari, F.V. (2010). Viruses and the autophagy machinery. Cell Cycle 9, 1295-1307.
21. Dye, B.T., Miller, D.J., and Ahlquist, P. (2005). In vivo self-interaction of nodavirus RNA replicase protein a revealed by fluorescence resonance energy transfer. J. Virol. 79, 8909-8919. (Pubitemid 40934802)
22. Egger, D., and Bienz, K. (2002). Recombination of poliovirus RNA proceeds in mixed replication complexes originating from distinct replication start sites. J. Virol. 76, 10960-10971. (Pubitemid 35176213)
23. Egger, D., Teterina, N., Ehrenfeld, E., and Bienz, K. (2000). Formation of the poliovirus replication complex requires coupled viral translation, vesicle production, and viral RNA synthesis. J. Virol. 74, 6570-6580. (Pubitemid 30429826)
24. Froshauer, S., Kartenbeck, J., and Helenius, A. (1988). Alphavirus RNA replicase is located on the cytoplasmic surface of endosomes and lysosomes. J. Cell Biol. 107, 2075-2086. (Pubitemid 19015087)
25. Fujita, K., Krishnakumar, S.S., Franco, D., Paul, A.V., London, E., and Wimmer, E. (2007). Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication. Biochemistry 46, 5185-5199. (Pubitemid 46683017)
26. Gosert, R., Kanjanahaluethai, A., Egger, D., Bienz, K., and Baker, S.C. (2002). RNA replication of mouse hepatitis virus takes place at double-membrane vesicles. J. Virol. 76, 3697-3708. (Pubitemid 34250534)
27. Grief, C., Galler, R., Côrtes, L.M., and Barth, O.M. (1997). Intracellular localisation of dengue-2 RNA in mosquito cell culture using electron microscopic in situ hybridisation. Arch. Virol. 142, 2347-2357. (Pubitemid 28017259)
28. Grimley, P.M., Berezesky, I.K., and Friedman, R.M. (1968). Cytoplasmic structures associated with an arbovirus infection: loci of viral ribonucleic acid synthesis. J. Virol. 2, 1326-1338.
29. Hatta, T., Bullivant, S., and Matthews, R.E. (1973). Fine structure of vesicles induced in chloroplasts of Chinese cabbage leaves by infection with turnip yellow mosaic virus. J. Gen. Virol. 20, 37-50.
30. Hsu, N.Y., Ilnytska, O., Belov, G., Santiana, M., Chen, Y.H., Takvorian, P.M., Pau, C., van der Schaar, H., Kaushik-Basu, N., Balla, T., et al. (2010). Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell 141, 799-811.
31. ICTV (2005). Virus Taxonomy: VIIIth Report of the International Committee on Taxonomy of Viruses. In Virus Taxonomy: VIIIth Report of the International Committee on Taxonomy of Viruses, C.M. Fauquet, M.A. Mayo, U. Maniloff, U. Desselberger, and L.A. Ball, eds. (Burlington, MA: Elsevier Academic Press).
32. Jackson, W.T., Giddings, T.H., Jr., Taylor, M.P., Mulinyawe, S., Rabinovitch, M., Kopito, R.R., and Kirkegaard, K. (2005). Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol. 3, e156.
33. Janda, M., and Ahlquist, P. (1998). Brome mosaic virus RNA replication protein 1a dramatically increases in vivo stability but not translation of viral genomic RNA3. Proc. Natl. Acad. Sci. USA 95, 2227-2232. (Pubitemid 28145923)
34. Kanjanahaluethai, A., Chen, Z., Jukneliene, D., and Baker, S.C. (2007). Membrane topology of murine coronavirus replicase nonstructural protein 3. Virology 361, 391-401. (Pubitemid 46584721)
35. Kao, C.C., and Ahlquist, P. (1992). Identification of the domains required for direct interaction of the helicase-like and polymerase-like RNA replication proteins of brome mosaic virus. J. Virol. 66, 7293-7302.
36. Katsafanas, G.C., and Moss, B. (2007). Colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions. Cell Host Microbe 2, 221-228. (Pubitemid 47500820)
37. Kirkegaard, K. (2009). Subversion of the cellular autophagy pathway by viruses. Curr. Top. Microbiol. Immunol. 335, 323-333.
38. Knoops, K., Kikkert, M., Worm, S.H., Zevenhoven-Dobbe, J.C., van der Meer, Y., Koster, A.J., Mommaas, A.M., and Snijder, E.J. (2008). SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum. PLoS Biol. 6, e226.
39. Knoops, K., Swett-Tapia, C., van den Worm, S.H., Te Velthuis, A.J., Koster, A.J., Mommaas, A.M., Snijder, E.J., and Kikkert, M. (2010). Integrity of the early secretory pathway promotes, but is not required for, severe acute respiratory syndrome coronavirus RNA synthesis and virus-induced remodeling of endoplasmic reticulum membranes. J. Virol. 84, 833-846.
40. Kong, F., Sivakumaran, K., and Kao, C. (1999). The N-terminal half of the brome mosaic virus 1a protein has RNA capping-associated activities: specificity for GTP and S-adenosylmethionine. Virology 259, 200-210. (Pubitemid 29391770)
41. Kopek, B.G., Perkins, G., Miller, D.J., Ellisman, M.H., and Ahlquist, P. (2007). Three-dimensional analysis of a viral RNA replication complex reveals a virus-induced mini-organelle. PLoS Biol. 5, e220.
42. Lanman, J., Crum, J., Deerinck, T.J., Gaietta, G.M., Schneemann, A., Sosinsky, G.E., Ellisman, M.H., and Johnson, J.E. (2008). Visualizing flock house virus infection in Drosophila cells with correlated fluorescence and electron microscopy. J. Struct. Biol. 161, 439-446. (Pubitemid 351375095)
43. Lee, E.G., and Linial, M.L. (2008). The C terminus of foamy retrovirus Gag contains determinants for encapsidation of Pol protein into virions. J. Virol. 82, 10803-10810. (Pubitemid 352691151)
44. Lindenbach, B.D., and Rice, C.M. (2003). Molecular biology of flaviviruses. Adv. Virus Res. 59, 23-61. (Pubitemid 137639363)
45. Lindenbach, B.D., Thiel, H.-J., and Rice, C.M. (2007). Flaviviridae: The Viruses and Their Replication. In Fields Virology, D.M. Knipe, P.M. Howley, D.E. Griffin, R.A. Lamb, M.A. Martin, B. Roizman, and S.E. Straus, eds. (Philadelphia: Lippincott Williams & Wilkins), pp. 1101-1152.
46. Linial, M.L. (1999). Foamy viruses are unconventional retroviruses. J. Virol. 73, 1747-1755. (Pubitemid 29098073)
47. Liu, L., Westler, W.M., den Boon, J.A., Wang, X., Diaz, A., Steinberg, H.A., and Ahlquist, P. (2009). An amphipathic alpha-helix controls multiple roles of brome mosaic virus protein 1a in RNA replication complex assembly and function. PLoS Pathog. 5, e1000351.
48. Mackenzie, J. (2005). Wrapping things up about virus RNA replication. Traffic 6, 967-977. (Pubitemid 41472456)
49. Mackenzie, J.M., Jones, M.K., and Young, P.R. (1996). Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication. Virology 220, 232-240. (Pubitemid 26201681)
50. Mackenzie, J.M., Khromykh, A.A., Jones, M.K., and Westaway, E.G. (1998). Subcellular localization and some biochemical properties of the flavivirus Kunjin nonstructural proteins NS2A and NS4A. Virology 245, 203-215. (Pubitemid 28394183)
51. Mallardo, M., Schleich, S., and Krijnse Locker, J. (2001). Microtubule-dependent organization of vaccinia virus core-derived early mRNAs into distinct cytoplasmic structures. Mol. Biol. Cell 12, 3875-3891. (Pubitemid 34001080)
52. McLauchlan, J. (2009). Lipid droplets and hepatitis C virus infection. Biochim. Biophys. Acta 1791, 552-559.
53. Miller, D.J., and Ahlquist, P. (2002). Flock house virus RNA polymerase is a transmembrane protein with amino-terminal sequences sufficient for mitochondrial localization and membrane insertion. J. Virol. 76, 9856-9867. (Pubitemid 35006525)
54. Miller, S., and Krijnse-Locker, J. (2008). Modification of intracellular membrane structures for virus replication. Nat. Rev. Microbiol. 6, 363-374. (Pubitemid 351552657)
55. Miller, D.J., Schwartz, M.D., and Ahlquist, P. (2001). Flock house virus RNA replicates on outer mitochondrial membranes in Drosophila cells. J. Virol. 75, 11664-11676. (Pubitemid 33063258)
56. Miller, S., Sparacio, S., and Bartenschlager, R. (2006). Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B. J. Biol. Chem. 281, 8854-8863. (Pubitemid 43847992)
57. Miller, S., Kastner, S., Krijnse-Locker, J., Bühler, S., and Bartenschlager, R. (2007). The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner. J. Biol. Chem. 282, 8873-8882. (Pubitemid 47093477)
58. Miller, C.L., Arnold, M.M., Broering, T.J., Hastings, C.E., and Nibert, M.L. (2010). Localization of mammalian orthoreovirus proteins to cytoplasmic factory-like structures via nonoverlapping regions of microNS. J. Virol. 84, 867-882.
59. Moebes, A., Enssle, J., Bieniasz, P.D., Heinkelein, M., Lindemann, D., Bock, M., McClure, M.O., and Rethwilm, A. (1997). Human foamy virus reverse transcription that occurs late in the viral replication cycle. J. Virol. 71, 7305-7311. (Pubitemid 27391668)
60. Morita, E., and Sundquist, W.I. (2004). Retrovirus budding. Annu. Rev. Cell Dev. Biol. 20, 395-425. (Pubitemid 39488644)
61. Novoa, R.R., Calderita, G., Arranz, R., Fontana, J., Granzow, H., and Risco, C. (2005). Virus factories: associations of cell organelles for viral replication and morphogenesis. Biol. Cell 97, 147-172. (Pubitemid 40298269)
62. Nugent, C.I., Johnson, K.L., Sarnow, P., and Kirkegaard, K. (1999). Functional coupling between replication and packaging of poliovirus replicon RNA. J. Virol. 73, 427-435. (Pubitemid 28565387)
63. O'Reilly, E.K., Tang, N., Ahlquist, P., and Kao, C.C. (1995). Biochemical and genetic analyses of the interaction between the helicase-like and polymerase- like proteins of the brome mosaic virus. Virology 214, 59-71. (Pubitemid 3008462)
64. Ogawa, K., Hishiki, T., Shimizu, Y., Funami, K., Sugiyama, K., Miyanari, Y., and Shimotohno, K. (2009). Hepatitis C virus utilizes lipid droplet for production of infectious virus. Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. 85, 217-228.
65. Oostra, M., Hagemeijer, M.C., van Gent, M., Bekker, C.P., te Lintelo, E.G., Rottier, P.J., and de Haan, C.A. (2008). Topology and membrane anchoring of the coronavirus replication complex: not all hydrophobic domains of nsp3 and nsp6 are membrane spanning. J. Virol. 82, 12392-12405.
66. Patton, J.T., Silvestri, L.S., Tortorici, M.A., Vasquez-Del Carpio, R., and Taraporewala, Z.F. (2006). Rotavirus genome replication and morphogenesis: role of the viroplasm. Curr. Top. Microbiol. Immunol. 309, 169-187. (Pubitemid 47400277)
67. Pedersen, K.W., van der Meer, Y., Roos, N., and Snijder, E.J. (1999). Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex. J. Virol. 73, 2016-2026. (Pubitemid 29098104)
68. Racaniello, V.R. (2007). Picornaviridae: The Viruses and Their Replication. In Fields Virology, D.M. Knipe, P.M. Howley, D.E. Griffin, R.A. Lamb, M.A. Martin, B. Roizman, and S.E. Straus, eds. (Philadelphia: Lippincott Williams & Wilkins), pp. 795-838.
69. Reggiori, F., Monastyrska, I., Verheije, M.H., Calì, T., Ulasli, M., Bianchi, S., Bernasconi, R., de Haan, C.A., and Molinari, M. (2010). Coronaviruses Hijack the LC3-I-positive EDEMosomes, ER-derived vesicles exporting short-lived ERAD regulators, for replication. Cell Host Microbe 7, 500-508.
70. Reinisch, K.M., Nibert, M.L., and Harrison, S.C. (2000). Structure of the reovirus core at 3.6 A resolution. Nature 404, 960-967. (Pubitemid 30243583)
71. Restrepo-Hartwig, M.A., and Ahlquist, P. (1996). Brome mosaic virus helicaseand polymerase-like proteins colocalize on the endoplasmic reticulum at sites of viral RNA synthesis. J. Virol. 70, 8908-8916. (Pubitemid 26378475)
72. Restrepo-Hartwig, M., and Ahlquist, P. (1999). Brome mosaic virus RNA replication proteins 1a and 2a colocalize and 1a independently localizes on the yeast endoplasmic reticulum. J. Virol. 73, 10303-10309.
73. Russo, M., and Martelli, G.P. (1972). Ultrastructural observations on tomato bushy stunt virus in plant cells. Virology 49, 122-129.
74. Rust, R.C., Landmann, L., Gosert, R., Tang, B.L., Hong, W., Hauri, H.P., Egger, D., and Bienz, K. (2001). Cellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex. J. Virol. 75, 9808-9818. (Pubitemid 32900116)
75. Salonen, A., Ahola, T., and Kl̀l̀ril̀inen, L. (2005). Viral RNA replication in association with cellular membranes. Curr. Top. Microbiol. Immunol. 285, 139-173.
76. Samsa, M.M., Mondotte, J.A., Iglesias, N.G., Assunçao-Miranda, I., Barbosa-Lima, G., Da Poian, A.T., Bozza, P.T., and Gamarnik, A.V. (2009). Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog. 5, e1000632.
77. Schlegel, A., Giddings, T.H., Jr., Ladinsky, M.S., and Kirkegaard, K. (1996). Cellular origin and ultrastructure of membranes induced during poliovirus infection. J. Virol. 70, 6576-6588. (Pubitemid 26307362)
78. Schramm, B., and Locker, J.K. (2005). Cytoplasmic organization of POXvirus DNA replication. Traffic 6, 839-846. (Pubitemid 41309393)
79. Schwartz, M., Chen, J., Janda, M., Sullivan, M., den Boon, J., and Ahlquist, P. (2002). A positive-strand RNA virus replication complex parallels form and function of retrovirus capsids. Mol. Cell 9, 505-514. (Pubitemid 34273782)
80. Schwartz, M., Chen, J., Lee, W.M., Janda, M., and Ahlquist, P. (2004). Alternate, virus-induced membrane rearrangements support positive-strand RNA virus genome replication. Proc. Natl. Acad. Sci. USA 101, 11263-11268. (Pubitemid 39038335)
81. Snijder, E.J., van Tol, H., Roos, N., and Pedersen, K.W. (2001). Non-structural proteins 2 and 3 interact to modify host cell membranes during the formation of the arterivirus replication complex. J. Gen. Virol. 82, 985-994. (Pubitemid 32454599)
82. Snijder, E.J., Bredenbeek, P.J., Dobbe, J.C., Thiel, V., Ziebuhr, J., Poon, L.L., Guan, Y., Rozanov, M., Spaan, W.J., and Gorbalenya, A.E. (2003). Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage. J. Mol. Biol. 331, 991-1004. (Pubitemid 36969960)
83. Snijder, E.J., van der Meer, Y., Zevenhoven-Dobbe, J., Onderwater, J.J., van der Meulen, J., Koerten, H.K., and Mommaas, A.M. (2006). Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J. Virol. 80, 5927-5940. (Pubitemid 43849170)
84. Stertz, S., Reichelt, M., Spiegel, M., Kuri, T., Martínez-Sobrido, L., García-Sastre, A., Weber, F., and Kochs, G. (2007). The intracellular sites of early replication and budding of SARS-coronavirus. Virology 361, 304-315. (Pubitemid 46574851)
85. Suhy, D.A., Giddings, T.H., Jr., and Kirkegaard, K. (2000). Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles. J. Virol. 74, 8953-8965.
86. Sullivan, M.L., and Ahlquist, P. (1999). A brome mosaic virus intergenic RNA3 replication signal functions with viral replication protein 1a to dramatically stabilize RNA in vivo. J. Virol. 73, 2622-2632. (Pubitemid 29135646)
87. Taylor, M.P., and Kirkegaard, K. (2008). Potential subversion of autophagosomal pathway by picornaviruses. Autophagy 4, 286-289. (Pubitemid 351458088)
88. Teterina, N.L., Gorbalenya, A.E., Egger, D., Bienz, K., and Ehrenfeld, E. (1997). Poliovirus 2C protein determinants of membrane binding and rearrangements in mammalian cells. J. Virol. 71, 8962-8972. (Pubitemid 27492335)
89. Teterina, N.L., Gorbalenya, A.E., Egger, D., Bienz, K., Rinaudo, M.S., and Ehrenfeld, E. (2006). Testing the modularity of the N-terminal amphipathic helix conserved in picornavirus 2C proteins and hepatitis C NS5A protein. Virology 344, 453-467. (Pubitemid 43049632)
90. Thiel, V., Ivanov, K.A., Putics, A., Hertzig, T., Schelle, B., Bayer, S., Weissbrich, B., Snijder, E.J., Rabenau, H., Doerr, H.W., et al. (2003). Mechanisms and enzymes involved in SARS coronavirus genome expression. J. Gen. Virol. 84, 2305-2315. (Pubitemid 37063118)
91. Tolonen, N., Doglio, L., Schleich, S., and Krijnse Locker, J. (2001). Vaccinia virus DNA replication occurs in endoplasmic reticulum-enclosed cytoplasmic mini-nuclei. Mol. Biol. Cell 12, 2031-2046. (Pubitemid 33049697)
92. van Hemert, M.J., de Wilde, A.H., Gorbalenya, A.E., and Snijder, E.J. (2008a). The in vitro RNA synthesizing activity of the isolated arterivirus replication/transcription complex is dependent on a host factor. J. Biol. Chem. 283, 16525-16536.
93. van Hemert, M.J., van den Worm, S.H., Knoops, K., Mommaas, A.M., Gorbalenya, A.E., and Snijder, E.J. (2008b). SARS-coronavirus replication/transcription complexes are membrane-protected and need a host factor for activity in vitro. PLoS Pathog. 4, e1000054.
94. Van Wynsberghe, P.M., and Ahlquist, P. (2009). 50 cis elements direct nodavirus RNA1 recruitment to mitochondrial sites of replication complex formation. J. Virol. 83, 2976-2988.
95. Van Wynsberghe, P.M., Chen, H.R., and Ahlquist, P. (2007). Nodavirus RNA replication protein a induces membrane association of genomic RNA. J. Virol. 81, 4633-4644. (Pubitemid 46668661)
96. Venter, P.A., and Schneemann, A. (2008). Recent insights into the biology and biomedical applications of Flock House virus. Cell. Mol. Life Sci. 65, 2675-2687.
97. Venter, P.A., Krishna, N.K., and Schneemann, A. (2005). Capsid protein synthesis from replicating RNA directs specific packaging of the genome of a multipartite, positive-strand RNA virus. J. Virol. 79, 6239-6248. (Pubitemid 40617228)
98. Waheed, A.A., and Freed, E.O. (2009). Lipids and membrane microdomains in HIV-1 replication. Virus Res. 143, 162-176.
99. Wang, X., Lee, W.M., Watanabe, T., Schwartz, M., Janda, M., and Ahlquist, P. (2005). Brome mosaic virus 1a nucleoside triphosphatase/helicase domain plays crucial roles in recruiting RNA replication templates. J. Virol. 79, 13747-13758. (Pubitemid 41508186)
100. Welsch, S., Miller, S., Romero-Brey, I., Merz, A., Bleck, C.K., Walther, P., Fuller, S.D., Antony, C., Krijnse-Locker, J., and Bartenschlager, R. (2009). Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe 5, 365-375.
101. Yin, J., Liu, Y., Wimmer, E., and Paul, A.V. (2007). Complete protein linkage map between the P2 and P3 non-structural proteins of poliovirus. J. Gen. Virol. 88, 2259-2267. (Pubitemid 47194223)
102. Zhang, X., Walker, S.B., Chipman, P.R., Nibert, M.L., and Baker, T.S. (2003). Reovirus polymerase lambda 3 localized by cryo-electron microscopy of virions at a resolution of 7.6 A. Nat. Struct. Biol. 10, 1011-1018. (Pubitemid 37500493)
103. Ziebuhr, J., Snijder, E.J., and Gorbalenya, A.E. (2000). Virus-encoded proteinases and proteolytic processing in the Nidovirales. J. Gen. Virol. 81, 853-879. (Pubitemid 30189624)