21-Hydroxylase epitopes are targeted by CD8 T cells in autoimmune Addison's disease

Journal of Autoimmunity

Volumn 35, Issue 4, 2010, Pages 309-315

  Rottembourg, Diane ^a   Deal, Cheri ^a   Lambert, Marion ^b   Mallone, Roberto ^b   Carel, Jean Claude ^c   Lacroix, André ^d   Caillat Zucman, Sophie ^b   Le Deist, Françoise ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

^b INSERM   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

^d CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

21 Hydroxylase; Addison's disease; APECED; Autoimmune polyglandular syndrome; Epitope mapping study; T cell epitope

Indexed keywords

AUTOANTIBODY; BIOLOGICAL MARKER; CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; HLA B35 ANTIGEN; STEROID 21 MONOOXYGENASE; TETRAMER;

ADDISON DISEASE; ADOLESCENT; ADRENAL INSUFFICIENCY; ADULT; AMINO ACID SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CD8+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; ENZYME LINKED IMMUNOSPOT ASSAY; EPITOPE MAPPING; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MALE; PREVALENCE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

EID: 77958153605     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2010.07.001     Document Type: Article

References (36)

1. Arlt W., Allolio B. Adrenal insufficiency. Lancet 2003, 361:1881-1893.
2. Betterle C., Lazzarotto F., Presotto F. Autoimmune polyglandular syndrome type 2: the tip of an iceberg?. Clin Exp Immunol 2004, 137:225-233.
3. Uibo R., Aavik E., Peterson P., Perheentupa J., Aranko S., Pelkonen R., et al. Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease. J Clin Endocrinol Metab 1994, 78:323-328.
4. Coco G., Dal Pra C., Presotto F., Albergoni M.P., Canova C., Pedini B., et al. Estimated risk for developing autoimmune Addison's disease in patients with adrenal cortex autoantibodies. J Clin Endocrinol Metab 2006, 91:1637-1645.
5. Betterle C., Zanette F., Zanchetta R., Pedini B., Trevisan A., Mantero F., et al. Complement-fixing adrenal autoantibodies as a marker for predicting onset of idiopathic Addison's disease. Lancet 1983, 1:1238-1241.
6. Neville A.M., Mackay A.M. The structure of the human adrenal cortex in health and disease. Clin Endocrinol Metab 1972, 1:361-395.
7. Irvine W.J., Stewart A.G., Scarth L. A clinical and immunological study of adrenocortical insufficiency (Addison's disease). Clin Exp Immunol 1967, 2:31-70.
8. Gombos Z., Hermann R., Kiviniemi M., Nejentsev S., Reimand K., Fadeyev V., et al. Analysis of extended human leukocyte antigen haplotype association with Addison's disease in three populations. Eur J Endocrinol 2007, 157:757-761.
9. Myhre A.G., Undlien D.E., Lovas K., Uhlving S., Nedrebo B.G., Fougner K.J., et al. Autoimmune adrenocortical failure in Norway autoantibodies and human leukocyte antigen class II associations related to clinical features. J Clin Endocrinol Metab 2002, 87:618-623.
10. Betterle C., Scalici C., Presotto F., Pedini B., Moro L., Rigon F., et al. The natural history of adrenal function in autoimmune patients with adrenal autoantibodies. J Endocrinol 1988, 117:467-475.
11. Price P., Witt C., Allcock R., Sayer D., Garlepp M., Kok C.C., et al. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases. Immunol Rev 1999, 167:257-274.
12. Consortium F-GA An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 1997, 17:399-403.
13. Freeman M., Weetman A.P. T and B cell reactivity to adrenal antigens in autoimmune Addison's disease. Clin Exp Immunol 1992, 88:275-279.
14. Bratland E., Skinningsrud B., Undlien D.E., Mozes E., Husebye E.S. T cell responses to steroid cytochrome P450 21-hydroxylase in patients with autoimmune primary adrenal insufficiency. J Clin Endocrinol Metab 2009, 94:5117-5124.
15. Vendrame F., Segni M., Grassetti D., Tellone V., Augello G., Trischitta V., et al. Impaired caspase-3 expression by peripheral T cells in chronic autoimmune thyroiditis and in autoimmune polyendocrine syndrome-2. J Clin Endocrinol Metab 2006, 91:5064-5068.
16. Kriegel M.A., Lohmann T., Gabler C., Blank N., Kalden J.R., Lorenz H.M. Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II. J Exp Med 2004, 199:1285-1291.
17. Di Lorenzo T.P., Peakman M., Roep B.O. Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 2007, 148:1-16.
18. Schloot N.C., Meierhoff G., Karlsson Faresjo M., Ott P., Putnam A., Lehmann P., et al. Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop. J Autoimmun 2003, 21:365-376.
19. Ten S., New M., Maclaren N. Clinical review 130: Addison's disease 2001. J Clin Endocrinol Metab 2001, 86:2909-2922.
20. Altman J.D., Moss P.A., Goulder P.J., Barouch D.H., McHeyzer-Williams M.G., Bell J.I., et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996, 274:94-96.
21. Pelfrey C.M., Rudick R.A., Cotleur A.C., Lee J.C., Tary-Lehmann M., Lehmann P.V. Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production. J Immunol 2000, 165:1641-1651.
22. Toma A., Haddouk S., Briand J.P., Camoin L., Gahery H., Connan F., et al. Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci U S A 2005, 102:10581-10586.
23. Mallone R., Martinuzzi E., Blancou P., Novelli G., Afonso G., Dolz M., et al. CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes. Diabetes 2007, 56:613-621.
24. Martinuzzi E., Novelli G., Scotto M., Blancou P., Bach J.M., Chaillous L., et al. The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment. Diabetes 2008, 57:1312-1320.
25. Trudeau J.D., Kelly-Smith C., Verchere C.B., Elliott J.F., Dutz J.P., Finegood D.T., et al. Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest 2003, 111:217-223.
26. Wucherpfennig K.W., Catz I., Hausmann S., Strominger J.L., Steinman L., Warren K.G. Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes. J Clin Invest 1997, 100:1114-1122.
27. Kita H., Lian Z.X., Van de Water J., He X.S., Matsumura S., Kaplan M., et al. Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells. J Exp Med 2002, 195:113-123.
28. Weenink S.M., Lo J., Stephenson C.R., McKinney P.A., Ananieva-Jordanova R., Rees Smith B., et al. Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in type 1 diabetes. J Autoimmun 2009, 33:147-154.
29. Volpato M., Prentice L., Chen S., Betterle C., Rees Smith B., Furmaniak J. A study of the epitopes on steroid 21-hydroxylase recognized by autoantibodies in patients with or without Addison's disease. Clin Exp Immunol 1998, 111:422-428.
30. Nikoshkov A., Falorni A., Lajic S., Laureti S., Wedell A., Lernmark K., et al. A conformation-dependent epitope in Addison's disease and other endocrinological autoimmune diseases maps to a carboxyl-terminal functional domain of human steroid 21-hydroxylase. J Immunol 1999, 162:2422-2426.
31. Maecker H.T., Dunn H.S., Suni M.A., Khatamzas E., Pitcher C.J., Bunde T., et al. Use of overlapping peptide mixtures as antigens for cytokine flow cytometry. J Immunol Methods 2001, 255:27-40.
32. Rock K.L., Shen L. Cross-presentation: underlying mechanisms and role in immune surveillance. Immunol Rev 2005, 207:166-183.
33. Jackson R., McNicol A.M., Farquharson M., Foulis A.K. Class II MHC expression in normal adrenal cortex and cortical cells in autoimmune Addison's disease. J Pathol 1988, 155:113-120.
34. Zhang H., Hong H., Li D., Ma S., Di Y., Stoten A., et al. Comparing pooled peptides with intact protein for accessing cross-presentation pathways for protective CD8+ and CD4+ T cells. J Biol Chem 2009, 284:9184-9191.
35. Bratland E., Bredholt G., Mellgren G., Knappskog P.M., Mozes E., Husebye E.S. The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: the major autoantigen in autoimmune Addison's disease. J Autoimmun 2009, 33:58-67.
36. Soderbergh A., Myhre A.G., Ekwall O., Gebre-Medhin G., Hedstrand H., Landgren E., et al. Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 2004, 89:557-562.