Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation

American Journal of Respiratory Cell and Molecular Biology

Volumn 43, Issue 4, 2010, Pages 403-412

  Deuse, Tobias ^a   Blankenberg, Francis ^a   Haddad, Munif ^b   Reichenspurner, Hermann ^b   Phillips, Neil ^a   Robbins, Robert C ^a   Schrepfer, Sonja ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Aerosol drug therapy; Immunosuppression; Inhaled tacrolimus; Lung transplantation; NF B

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 13; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TACROLIMUS; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; MUCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG SCREENING; FEASIBILITY STUDY; GENE EXPRESSION; HISTOLOGY; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG TRANSPLANTATION; LYMPHOCYTE; MORPHOLOGY; NONHUMAN; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TIGHT JUNCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; DRUG EFFECT; EPITHELIUM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOASSAY; INHALATIONAL DRUG ADMINISTRATION; LEWIS RAT; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

RATTUS;

ADMINISTRATION, INHALATION; ANIMALS; CELL SURVIVAL; CYTOKINES; EPITHELIUM; GENE EXPRESSION REGULATION; HUMANS; IMMUNOASSAY; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; LUNG TRANSPLANTATION; MODELS, ANIMAL; MUCINS; NF-KAPPA B; RATS; RATS, INBRED LEW; SIGNAL TRANSDUCTION; TACROLIMUS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 77958140446     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2009-0208OC     Document Type: Article

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