FK506-binding proteins regulate smooth muscle contractility by altering neurotransmitter release

European Journal of Pharmacology

Volumn 333, Issue 2-3, 1997, Pages 223-229

  Kageyama, Masaaki ^a   Fujita, Hiromi ^a   Goto, Wakana ^a   Nakata, Katsuhiko ^a   Shirasawa, Eiichi ^a   Kanai, Atsushi ^b  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Ascomycin; Fk506 binding protein; Iris sphincter muscle; Neurotransmitter release; Rabbit; Smooth muscle concentration; Tachykininergic nerve

Indexed keywords

ASCOMYCIN; CALCIUM CHANNEL; CAPSAICIN; CONOTOXIN; FK 506 BINDING PROTEIN; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NICARDIPINE; RAPAMYCIN; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE CONTRACTILITY; SPHINCTER PUPILLAE MUSCLE;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CAPSAICIN; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOSUPPRESSIVE AGENTS; INDOLES; IRIS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; POLYENES; RABBITS; RECEPTORS, TACHYKININ; SIROLIMUS; SYNAPTIC TRANSMISSION; TACHYKININS; TACROLIMUS;

EID: 0030967889     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01146-1     Document Type: Article

References (31)

1. 2+-activated phosphatase in mammalian brain. Trends Neurosci. 12:1989;117.
2. Clipstone N.A., Crabtree G.R. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature. 357:1992;695.
3. Dawson T.M., Steiner J.P., Dawson V.L., Dinerman J.L., Uhl G.R., Snyder S.H. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc. Natl. Acad. Sci. USA. 90:1993;9808.
4. Dumont F.J., Melino M.R., Staruch M.J., Koprak S.L., Fischer P.A., Sigal N.H. The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T-cells. J. Immunol. 144:1990;1418.
5. Dumont F.J., Staruch M.J., Koprak S.L., Siekierka J.J., Lin C.S., Harrison R., Sewell T., Kindt V.M., Beattie T.R., Wyvratt M., Sigal N.H. The Immunosuppressive and toxic effects of FK-506 are mechanistically related: Pharmacology of a novel antagonist of FK-506 and rapamycin. J. Exp. Med. 176:1992;751.
6. Folkers K., Håkanson R., Hörig J., Jie-Cheng X., Leander S. Biological evaluation of substance P antagonists. Br. J. Pharmacol. 83:1984;449.
7. Fujii T., Murai M., Morimoto H., Maeda Y., Yamaoka M., Hagiwara D., Miyake H., Ikari N., Matsuo M. Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. Br. J. Pharmacol. 107:1992;785.
8. Harding M.W., Galat A., Uehling D.E., Schreiber S.L. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature. 341:1989;758.
9. Hell J.W., Yokoyama C.T., Breeze L.J., Chavkin C., Catterall W.A. Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neurons. EMBO J. 14:1995;3036.
10. Holzer P. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 43:1991;143.
11. 2+-dependent processes. Proc. Natl. Acad. Sci. USA. 83:1986;3733.
12. 2+ channels in KCl- and veratridine-evoked transmitter release from non-adrenergic, non-cholinergic nerves in the rabbit iris sphincter muscle. Naunyn-Schmiedebergs Arch, Pharmacol. 355, in press.
13. Kageyama, M., Fujita, H., Nakata, K., Shirasawa, E., Kanai, A., 1997b. Effects of the immunosuppressant cyclosporin A on neurotransmitter release from peripheral non-adrenergic, non-cholinergic nerves. Naunyn-Schmiedebergs Arch. Pharmacol., in press.
14. Leander S., Håkanson R., Rosell S., Folkers K., Sundler F., Tornqvist K. A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation. Nature. 294:1981;467.
15. Liu J., Farmer J.D. Jr., Lane W.S., Friedman J., Weissman I., Schreiber S.L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:1991;807.
16. Liu J.-P., Sim A.T.R., Robinson P.J. Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization. Science. 265:1994;970.
17. Lyson T., Ermel L.D., Belshaw P.J., Alberg D.G., Schreiber S.L., Victor R.G. Cyclosporine- and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. Circ. Res. 73:1993;596.
18. Maki N., Sekiguchi F., Nishimaki J., Miwa K., Hayano T., Takahashi N., Suzuki M. Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin. Proc. Natl. Acad. Sci. USA. 87:1990;5440.
19. O'keefe S.J., Tamura J., Kincaid R.L., Tocci M.J., O'Neill E.A. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature. 357:1992;692.
20. 13C ]ascomycin, bound to FKBP: Conformation and regions of ascomycin involved in binding J. Med. Chem. 34:1991;2925.
21. Price D.J., Grove J.R., Calvo V., Avruch J., Bierer B.E. Rapamycin-induced inhibition of the 70 kDa S6 protein kinase. Science. 257:1992;973.
22. Sculptoreanu A., Figourov A., De Groat W.C. Voltage-dependent potentiation of neuronal L-type calcium channels due to state-dependent phosphorylation. Am. J. Physiol. 269:1995;C725.
23. Siekierka J.J., Hung S.H.Y., Poe M., Lin C.S., Sigal N.H. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature. 341:1989;755.
24. Snyder S.H., Sabatini D.M. Immunophilins and the nervous system. Nature Med. 1:1995;32.
25. Steiner J.P., Dawson T.M., Fotuhi M., Glatt C.E., Snowman A.M., Cohen N., Snyder S.H. High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature. 358:1992;584.
26. Terada N., Franklin R.A., Lucas J.J., Blenis J., Gelfand E.W. Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase. J. Biol. Chem. 268:1993;12062.
27. Thomson A.W. FK-506: How much potential. Immunol. Today. 10:1989;6.
28. Ueda N., Muramatsu I., Fujiwara M. Capsaicin and bradykinin-induced substance P-ergic responses in the iris sphincter muscle of the rabbit. J. Pharmacol. Exp. Ther. 230:1984;469.
29. Ueda N., Muramatsu I., Hayashi H., Fujiwara M. Trigeminal nerve: The possible origin of substance P-nergic response in isolated rabbit iris sphincter muscle. Life Sci. 31:1982;369.
30. Victor R.G., Thomas G.D., Marban E., O'Rourke B. Presynaptic modulation of cortical synaptic activity by calcineurin. Proc. Natl. Acad. Sci. USA. 92:1995;6269.
31. Yang S.-D., Tallant E.A., Cheung W.Y. Calcineurin is a calmodulin-dependent protein phosphatase. Biochem. Biophys. Res. Commun. 106:1982;1419.