Simulation of bone tissue formation within a porous scaffold under dynamic compression

Biomechanics and Modeling in Mechanobiology

Volumn 9, Issue 5, 2010, Pages 583-596

  Milan, Jean Louis ^a   Planell, Josep A ^a   Lacroix, Damien ^a  

^a UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

Author keywords

Bone tissue engineering; Finite element analysis; Mechanoregulation; Scaffold; Tissue differentiation

Indexed keywords

BONE; COMPACTION; COMPUTERIZED TOMOGRAPHY; DYNAMICS; SCAFFOLDS (BIOLOGY); STRAIN RATE;

BONE TISSUE ENGINEERING; BONE TISSUE FORMATION; CONTROLLED DYNAMICS; DYNAMIC COMPRESSION; FIBROUS TISSUE; FINITE ELEMENT ANALYSE; MATURE BONE; MECHANO-REGULATION; POROUS SCAFFOLD; TISSUE DIFFERENTIATION;

FINITE ELEMENT METHOD;

ARTICLE; BONE DEVELOPMENT; COMPUTER ASSISTED TOMOGRAPHY; FINITE ELEMENT ANALYSIS; THEORETICAL MODEL; TISSUE ENGINEERING;

BONE DEVELOPMENT; FINITE ELEMENT ANALYSIS; MODELS, THEORETICAL; TISSUE ENGINEERING; TOMOGRAPHY, X-RAY COMPUTED;

EID: 77958113409     PISSN: 16177959     EISSN: 16822978     Source Type: Journal    
DOI: 10.1007/s10237-010-0199-5     Document Type: Article

References (37)

1. T Adachi KI Tsubota Y Tomita SJ Hollister 2001 Trabecular surface remodelling simulation for cancellous bone using microstructural voxel finite element models J Biomech Eng 123 403 409 10.1115/1.1392315
2. T Adachi Y Osako M Tanaka M Hojo SJ Hollister 2006 Framework for optimal design of porous scaffold microstructure by computational simulation of bone regeneration Biomaterials 27 21 3964 3972 10.1016/j.biomaterials.2006.02.039
3. Anderson CB (1967) Mechanics of fluids. In: Baumeister T (ed) Marks' saturated handbook of mechanical engineers, pp 3.48-3.76
4. Anderson JM (2000) The cellular cascades of wound healing. In: Davies JE (ed) Bone engineering, Toronto, EM squared, pp 81-93
5. RG Bacabac TH Smit SC Cowin JJWA Van Loon FTM Nieuwstadt R Heethaar J Klein-Nulend 2005 Dynamic shear stress in parallel-plate flow chambers J Biomech 38 159 167
6. ME Bolander 1992 Regulation of fracture repair by growth factors Proc Soc Exp Biol Med 200 165 170
7. N Bölgen Y Yang P Korkusuz E Güzel AJ El Haj E Pişkin 2008 Three-dimensional ingrowth of bone cells within biodegradable cryogel scaffolds in bioreactors at different regimes Tissue Eng 14 10 1743 1750 10.1089/ten.tea.2007.0277
8. DP Byrne D Lacroix JA Planell DJ Kelly PJ Prendergast 2007 Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus and dissolution rate: application of mechanobiological models in tissue engineering Biomaterials 28 5544 5554 10.1016/j.biomaterials.2007.09.003
9. DR Carter DP Fyhrie RT Whalen 1987 Trabecular bone density and loading history: regulation of connective tissue biology by mechanical energy J Biomech 20 785 794 10.1016/0021-9290(87)90058-3
10. SH Cartmell BD Porter AJ Garcia RE Guldberg 2003 Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro Tissue Eng 9 6 1197 1203 10.1089/10763270360728107
11. ND Case AO Duty A Ratcliffe R Müller RE Guldberg 2003 Bone formation on tissue-engineered cartilage constructs in vivo: effects of chondrocyte viability and mechanical loading Tissue Eng 9 4 587 596 10.1089/ 107632703768247296
12. BP Chan KW Leong 2008 Scaffolding in tissue engineering: general approaches and tissue-specific considerations Eur Spine J 17 Suppl. 4 467 479 10.1007/s00586-008-0745-3
13. M Charles-Harris S Del Valle E Hentges P Bleuet D Lacroix JA Planell 2007 Mechanical and structural characterisation of completely degradable polylactic acid/calcium phosphate glass scaffolds Biomaterials 28 4429 4438 10.1016/j.biomaterials.2007.06.029
14. M Charles-Harris MA Koch M Navarro D Lacroix E Engel JA Planell 2008 A PLA/calcium phosphate degradable composite material for bone tissue engineering: an in vitro study J Mater Sci Mater Med 19 1503 1513 10.1007/s10856-008-3390-9
15. S Checa PJ Prendergast 2009 A mechanobiological model for tissue differentiation that includes angiogenesis: a lattice-based modeling approach Ann Biomed Eng 37 1 129 145 10.1007/s10439-008-9594-9
16. AO Duty ME Oest RE Guldberg 2007 Cyclic mechanical compression increases mineralization of cell-seeded polymer scaffolds in vivo J Biomech Eng 129 531 539 10.1115/1.2746375
17. HM Frost 1997 Defining osteopenias and osteoporoses: another view (with insights from a new paradigm) Bone 20 5 385 391 10.1016/S8756-3282(97)00019-7
18. L Geris K Vandamme I Naert J Vander Sloten J Duyck H Van Oosterwyck 2008 Application of mechanoregulatory models to simulate peri-implant tissue formation in an in vivo bone chamber J Biomech 41 1 145 154 10.1016/j.jbiomech. 2007.07.008
19. R Huiskes WDV Driel PJ Prendergast K Søballe 1997 A biomechanical regulatory model for periprosthetic fibrous-tissue differentiation J Mater Sci Mater Med 8 12 785 788 10.1023/A:1018520914512
20. CT Hung RL Mauck CC Wang EG Lima GA Ateshian 2004 A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading Ann Biomed Eng 32 1 35 49 10.1023/B:ABME.0000007789.99565. 42
21. A Ignatius H Blessing A Liedert C Schmidt C Neidlinger-Wilke D Kaspar, et al. 2005 Tissue engineering of bone: effects of mechanical strain on osteoblastic cells in type I collagen matrices Biomaterials 26 3 311 318 10.1016/j.biomaterials.2004.02.045
22. H Isaksson O Comas CC van Donkelaar J Mediavilla W Wilson R Huiskes, et al. 2007 Bone regeneration during distraction osteogenesis: mechano-regulation by shear strain and fluid velocity J Biomech 40 9 2002 2011 10.1016/j.jbiomech. 2006.09.028
23. DJ Kelly PJ Prendergast 2006 Prediction of the optimal mechanical properties for a scaffold used in osteochondral defect repair Tissue Eng 12 9 2509 2519 10.1089/ten.2006.12.2509
24. H Khayyeri S Checa M Tägil PJ Prendergast 2009 Corroboration of mechanobiological simulations of tissue differentiation in an in vivo bone chamber using a lattice-modeling approach J Orthop Res 27 12 1659 1666 10.1002/jor.20926
25. JD Kisiday M Jin MA DiMicco B Kurz AJ Grodzinsky 2004 Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds J Biomech 37 595 604 10.1016/j.jbiomech.2003.10.005
26. D Lacroix PJ Prendergast 2002 A mechano-regulation model for tissue differentiation during fracture healing: analysis of gap size and loading J Biomech 35 9 1163 1171 10.1016/S0021-9290(02)00086-6
27. X Liu GL Niebur 2008 Bone ingrowth into a porous coated implant predicted by a mechano-regulatory tissue differentiation lgorithm Biomech Model Mechanobiol 7 4 335 344 10.1007/s10237-007-0100-3
28. LA McMahon AJ Reid VA Campbell PJ Prendergast 2008 Regulatory effects of mechanical strain on the chondrogenic differentiation of MSCs in a collagen-GAG scaffold: experimental and computational analysis Ann Biomed Eng 36 2 185 194 10.1007/s10439-007-9416-5
29. JL Milan JA Planell D Lacroix 2009 Computational modelling of the mechanical environment of osteogenesis within a polylactic acid-calcium phosphate glass scaffold Biomaterials 30 25 4219 4226 10.1016/j.biomaterials. 2009.04.026
30. M Navarro MP Ginebra JA Planell CC Barrias MA Barbosa 2005 In vitro degradation behavior of a novel bioresorbable composite material based on PLA and a soluble CaP glass Acta Biomater 1 4 411 419 10.1016/j.actbio.2005.03.004
31. M Navarro C Aparicio M Charles-Harris E Engel MP Ginebra JA Planell 2006 Development of a biodegradable composite scaffold for bone tissue engineering: physicochemical, topographical, mechanical, degradation and biological properties Adv Polym Sci 200 209 231 10.1007/12-068
32. B Porter R Zauel H Stockman R Guldberg D Fyhrie 2005 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor J Biomech 38 543 549 10.1016/j.jbiomech.2004.04.011
33. PJ Prendergast R Huiskes K Soballe 1997 Biophysical stimuli on cells during tissue differentiation at implant interfaces J Biomech 30 539 548 10.1016/S0021-9290(96)00140-6
34. K Rezwan QZ Chen JJ Blaker AR Boccaccini 2006 Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering Biomaterials 27 18 3413 3431 10.1016/j.biomaterials.2006.01.039
35. JA Sanz-Herrera JM García-Aznar M Doblaré 2009 On scaffold designing for bone regeneration: a computational multiscale approach Acta Biomater 5 219 229 10.1016/j.actbio.2008.06.021
36. JW Vehof JP Fisher D Dean JP van der Waerden PH Spauwen AG Mikos JA Jansen 2002 Bone formation in transforming growth factor beta-1-coated porous poly(propylene fumarate) scaffolds J Biomed Mater Res 60 241 251 10.1002/jbm.10073
37. SD Waldman DC Couto MD Grynpas RM Pilliar RA Kandel 2006 A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage Osteoarthr Cartilage 14 323 330 10.1016/j.joca.2005.10.007